[Gastrointestinal diseases in patients with bronchial asthma].
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Biomedical subjects
Publications and source records attributed to E V Gembitskiĭ.
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Within 1979-1989 the authors treated 26 wounded soldiers and officers with brain injury inflicted by mine explosion. 5 patients were in severe condition, 18 in extremely grave and 3 in critical condition. The patients had concomitant blast injuries and contusions. Pulmonary complications observed in such patients compused to DIC and respiratory distress syndromes running in the presence of marked metabolic disorders, hypoxia and intoxication. It is thought important that conservative therapy of respiratory disorders in patients with brain traumas were not constricted with correction of bronchial obstruction. The additional intensive treatment of the above syndromes is needed including extracorporeal detoxication (plasmapheresis) and hyperbaric oxygenation.
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The authors report 4 cases with hepatitis C infection running with vascular disorders: Raynaud syndrome (3 cases), mixed cryoglobulinemia (1 case), primary pulmonary hypertension (1 patient). Whether hepatitis C virus contributes to vascular disturbances is discussed and relevant literature is reviewed.
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A questionnaire survey covered 11 females with temporal arteritis (CA) and 20 healthy controls. Gastrointestinal, joint and spinal complaints were significantly more frequent in CA patients. Clinical characteristics of joint and spinal disorders in CA patients are close to those of chronic reactive arthritis. It is suggested that Horton's disease may be lacking as a stage of the infectious process in elderly patients (chronic intestinal and/or urinary infection-reactive arthritis-CA). A case is reported where CA developed after intestinal and urinary infection. Administration of antibiotics for treatment of the recurrence induced a continuous remission under reduced doses of glucocorticoids. In another case biseptol + glucocorticoids brought about a persistent remission allowing glucocorticoid discontinuation.
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In the authors' study it is shown that the mechanism of cardiovascular complications arising in prostatic cancer (PC) patients on estrogen therapy works through developing defects in coagulation which result in hypercoagulation and deterioration of blood rheology due to enhanced platelet aggregation. Activation of fibrinolytic enzymes seems to be an adaptive reaction decreasing hypercoagulation. The authors believe it necessary to evaluate cardiovascular and coagulative systems of PC patients before estrogen therapy to define the risk of probable complications, to design adequate prophylaxis and treatment with coronary-active and antihypertensive drugs, heparin, acetylsalicylic acid which help to prevent relevant cardiovascular complications and improve outcomes of the disease.
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The study was made of arachidonate-induced aggregation of peripheral blood monocytes in 18 patients with bronchial asthma versus 12 controls. Monocytic aggregation and dependence of the patients on glucocorticosteroids appeared related: in hormones untreated patients the aggregation was more active than in controls. The aggregation of hormone-dependent patients and controls showed no significant differences. Allergic reaction correlated in severity to aggregation intensity. The method of graphic registration of arachidonate-induced aggregation of peripheral blood monocytes is promising in evaluation of immunity macrophagal-monocytic component in asthmatic patients.