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Biomedical subjects

E V Gudkova

Publications and source records attributed to E V Gudkova.

7 recordsLinked to original sources
PubMed1992

[Sex differences in response to adrenaline in white rats].

Dynamics of changes of and plasma corticosterone was studied in both male and female rats after intraperitoneal injections of adrenaline at a dose of 20 micrograms per 100 g body weight. The control rats were injected with saline. Animals were decapitated 10, 30, 60, 120, 180 and 240 min after the injections. The specific effect of adrenaline was revealed in the first 10 min of adrenaline injection. This effect was significantly increased to 30-60 min after termination of saline--induced activation of the pituitary-adrenal axis. Both saline and adrenaline caused more significant increases in corticosterone levels in female rats than in male ones. There was a significant delay in the return of corticosterone to resting levels in males compared to that in females. It is supposed that the almost two-fold difference in peak plasma corticosterone concentrations observed after stressors may be associated with increased responsiveness of the female hypothalamus with respect to adrenaline secretion.

Animals↗
PubMed1991

[Determination of the enzyme activity of the fibrinolytic system using fibrinogen conjugated with peroxidase].

The authors suggest a method for enzymic fibrinolytic activity measurements, based on the detection in the solution of degradation products of fibrin, prelabeled with peroxidase. The method is highly sensitive, permits the detection in solution of as little as 0.01 MU per ml of plasminogen activator. As the basic method, it can be employed for measurements of plasminogen activator, plasminogen activator inhibitors, and plasmin inhibitors in biologic fluids, blood plasma including. Since the method is simple and the majority of its steps may be automated, it can be used in clinical laboratories.

Fibrin Fibrinogen Degradation Products↗
PubMed1991

[Sex differences in reserve capacity of the pituitary-adrenal system in rats].

Female rats exposed to complex emotional stress for 1 hour (restriction in the penal, vibration, loud dissonance music, interrupt light) simultaneously showed more considerable increases in plasma and adrenal corticosterone values than did male animals. Female rat corticosterone levels returned to basal values within 20-120 minutes of stressor-off. As for males the processes of restoration were delayed and accompanied by a 6-fold decrease in the plasma corticosterone levels compared with basal values. The response to additional acute stress (immobilization for 10 minutes) in various times after termination of complex emotional stress (0, 40, 120, 180, 240 minutes) was facilitated in females and remained unchanged in males. Plasma corticosterone levels under stressful conditions were 2-4-fold higher in females than in males. It is concluded that reserve capacity of adaptation system is significantly higher in female rats than in male ones.

Adaptation, Physiological↗
PubMedDate not supplied

[Formation of a stump after enucleation].

Despite the progress achieved in the treatment of ocular diseases, removal of the eyeball still has to be resorted to rather often. The records of 12 hospitals of Moscow over a year evidence 678 enucleations and eviscerations, 248 (39 percent) of these for oncologic diseases, 189 (29.1 percent) because of injury aftereffects, 153 (24 percent) because of glaucoma, and 58 (8 percent) because of ocular inflammations. Common enucleation was carried out in 203 of +/- 400 patients (except oncologic ones) and enucleation with implantation of biological and synthetic drafts in 197 cases, i.e. in half of the patients who needed it; this is explained by the absence of the necessary implants in hospitals. A bank of grafts should be created for centralized provision of ocular hospitals.

Adult↗