FORM-CELL RETICULOSIS OF MICE: AN INHERITED CONDITION RESEMBLING GAUCHER'S AND NIERMANN-PICK DISEASES.
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Biomedical subjects
Publications and source records attributed to E V HULSE.
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The total white cell count of the blood is of no value in assessing the degree of acute radiation damage in rats during the first 48 hours after exposure. This is because there is a transient neutrophilia after irradiation which counteracts, to a varying extent, the reduction in numbers of the other white cells. A similar neutrophilia occurs in human patients and there is no reason to expect that the total white cell count over the same period would be of any greater value in man. It is suggested, therefore, that the total white cell count of the blood is not suitable as a method for sorting radiation casualties.
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A radiographic method for studying the delay in gastric emptying in the rat caused by whole body irradiation has been applied to the investigation of two compounds which modify the effects of irradiation. The method may be of general use in the study of the action of drugs. Synkavit, which can potentiate the lethal effects of irradiation on tumours, caused a delay in gastric emptying. When Synkavit and irradiation were combined, a simple summation of the delays produced by each of these agents occurred. Cysteamine, which gives some protection against the lethal action of x-rays, also caused a delay in gastric emptying. It did not protect against the action of x-rays on stomach emptying.
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