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Biomedical subjects

E V Ivanov

Publications and source records attributed to E V Ivanov.

At least 19 recordsLinked to original sources
PubMed2005

[Varicose eczema: the etiology, pathogenesis and diagnosis. Part I].

Varicose eczema is a prevalent complication of chronic venous insufficiency. In view of the fact that the complicated forms of chronic venous insufficiency (classes 4-6 according to the clinical classification CEAP) are marked by the presence of dermatological changes, the reliable diagnosis of the given pathology is fairly pressing. The diagnosis of varicose eczema may be difficult for the phlebologist and, not infrequently, for the dermatologist because of the diversity of its manifestations. Besides, there is a number of diseases which resemble varicose eczema but require a different approach to their treatment. The Russian literature practically lacks the papers related to varicose eczema. The problems of the diagnosis and treatment including organizational questions have not been worked out. The surgeons regard this disease as dermatologic whereas the dermatologists consider it as surgical. As a result, the majority of patients do not receive adequate treatment. This paper covers the phlebologist's viewpoint of the problem of varicose eczema.

Chronic Disease↗
PubMed2005

[Varicose eczema: the etiology, pathogenesis and diagnosis. Part II].

Varicose eczema is a frequently occurring complication due to chronic venous insufficiency. In view of the fact that the complicated forms of chronic venous insufficiency (classes 4-6 according to the clinical classification CEAP) are associated with the presence of dermatological lesions, the reliable diagnosis of the given pathology presents a matter of great concern. For the phlebologist end, not infrequently, for the dermatologist the diagnosis of varicose eczema may be difficult because of the diversity of its manifestations. Also, there is a number of diseases that look like varicose eczema but require a different approach to the treatment. The Russian literature practically lacks the works related to varicose eczema. The problems of the diagnosis and treatment including the organizational aspects have not been worked out. The surgeons hold that this disease is dermatological whereas the dermatologists view it as surgical. As a result, the majority of patients do not receive adequate treatment. The paper describes the phlebologist's standpoint of the problem of varicose eczema. Part II of the paper reviews the differential diagnosis of varicose eczema.

Chronic Disease↗
PubMed1990

[A new skin radioprotective agent Diethon (experimental study)].

Results are presented on investigations of diethone--a new pharmaceutical to prevent and treat radiogenic skin injuries. Diethone is a synthetic antioxidant of the dihydropyridine-line. In experiment on animals the preparation was used in form of an ointment. Irradiation was done with beta- and soft roentgen rays in doses of 20 to 60 Gy on conditions of a tele- or contact radiotherapy. A reduction of intensity and duration of radio reactions by more than 50% and a slighter occurrence of radio reactions were shown. The protecting effect of diethone is much stronger than that of mexamine, cystamine and other radioprotectors. Application of this preparation in treatment of radiogenic dermatitides results in relief of inflammation appearances, in shortening of recovery-time, and in accelerated skin regeneration. The intravital investigations of skin by means of contact-luminescence-microscope and investigations using light- and electron-microscopy did not give any alterations in structure of regenerated skin in diethone-treated animals compared with control. Also a better conservation of protected intracellular membranes especially of mitochondrial membranes were seen. Generally penetration of 14C-diethone into skin occurs within two hours after application of ointment. It can not be found hardly within inner media.

Animals↗
PubMed1989

[Renoscintigraphy in the differential diagnosis of arterial hypertension].

Altogether 244 persons were examined. Of them 221 patients suffered from the syndrome of arterial hypertension, 23 were controls. Standard renoscintigraphy with 131I-hippuran was performed in all the patients. Routine indices: Tmax, T1/2 and T delta (RP retention mean time) were used as criteria for the assessment of renograms. The diagnostic accuracy of disorders of renal excretory function in patients with arterial hypertension by the results of assessment of renograms using routine indices was 65% only. The introduction of a new index T delta made it possible to raise the accuracy of examination by 35% as a result of the diagnosis of disorders of central hemodynamics.

Adult↗
PubMed1986

[Quantitative assessment of acute radiation damage to the crystalline lens].

This paper is an attempt to unify various approaches to the assessment of acute radiation injury of the organ of vision. The development of cataracts was studied on mice subjected to local irradiation of the head at doses: 7, 10, 12, 15, 20 and 25 Gy. A clinical picture of radiation injury of the eye at different x-ray doses at different stages was established during ophthalmological examination using a manual electro-ophthalmoscope (X5). A method of the quantitative assessment of radiation injury of the mouse eye at different radiation doses was proposed using the light transmission factor tau; its experimental value was obtained, values for different clinical stages of cataracts were established. The time course of the development of radiation cataracts in mice subjected to x-ray irradiation in a wide spectrum of doses, was observed; clinical features of the process were revealed. Dose fractionation under the above conditions did not make a protective effect on the lens. Dependence of a degree of lens injury on irradiation dose obtained owing to the use of the light transmission factor tau, was described with the following equation: (formula; see text)

Animals↗
PubMed1985

[Features of the intracellular repair of irradiated keratinocytes].

By means of light and electron microscopy, intracellular reparation has been studied after a local x-ray radiation of the rat paws (7.74 X 10(-1) Ci/kg) using radioprotectors (mexamin, cysteamin, ionol) and other chemical compounds (including membranoprotective ones). Restoration of the intracellular structures after x-ray burns proceeds more slowly and more complexly than reparation of the epidermis as a tissue system. To the slowly repairing intracellular formations belong mitochondria and, especially, internal mitochondrial membrane, as well as intercellular contacts. Under radiation mitochondria increase their volume at the expense of their three-fold swelling. Preliminary treatment of the skin with some of the compounds mentioned above decreases or completely prevents these changes. By means of the membranoactive chemical compounds, as well as by means of the known radioprotectors it is possible essentially to normalize the process of intracellular reparation and physiological regeneration of the ultrastructures, and in some cases, to stimulate reparative processes in them.

5-Methoxytryptamine↗
PubMed1984

[Combined diagnosis of kidney tumors].

A total of 127 patients were examined to determine the efficacy of the use of sonography, angionephroscintigraphy and roentgenocontrast angiography in renal tumors and the importance of these methods in diagnostic studies with suspicion for a renal tumor. All the patients were given ultrasound and radionuclide examination, 86 roentgenocontrast angiography. The study has shown a high sensitivity of all three methods in the diagnosis of sizable renal lesions though each one has a different diagnostic tendency. In vascularized tumors the combined use of sonography and angionephroscintigraphy practically ensures 100% diagnosis in a patient even at the out-patient stage of examination. The main difficulties occur in the differential diagnosis of hypovascular sizable tumors when the comparison of the results of all three methods makes it possible to establish correct diagnosis. The advantage of sonography is the absence of traumatism, that of angiography a possibility to determine the functional activity of both involved and intact kidneys. Roentgenocontrast angiography plays the leading role in defining the involvement of the renal and cava inferior veins by a tumor thrombus.

Adult↗
PubMed1984

Early haemodynamic effects of mitral valve prosthesis in patients with acquired heart disease.

42 patients with isolated mitral valve defect were divided into two groups: without cardiac complications -- and with acute myogenic heart failure, after implantation of a mitral valve prosthesis. In the first postoperative hours, a decrease in cardiac output and pulmonary hypertension were observed in both groups. By the end of the 1st postoperative day, cardiac output reached in both groups the initial level, but in patients of group 2 only thanks to catecholamine administration. The poor functional state of the heart before surgery is consequently the main cause of the fact that surgical intervention is not immediately followed by normalization of haemodynamics. Acute heart failure occurs in the early postoperative period in patients with an extremely impaired left ventricular pump function and with depleted myocardial reserves. In these patients, special attention must be given during surgery to myocardial protection.

Adolescent↗
PubMed1983

[Quantitative evaluation of the protective action of skin protectors].

The purpose of research was to study and give a comparative evaluation of cystamine, mexamine, ionol, dimethyl--sulfoxide, eugenic acid, castor oil and cholesterol as skin local radioprotectors. Experiments were made on random-bred albino rats. Skin areas 25 mm2 in size on each paw were irradiated. The exposure dose rate was 5 X 10(-3) A/kg (1160 p/min.), the surface dose 6.5 X 10(-1) and 7.7 X 10(-1) Q/kg (2500 and 3000 P respectively). The time period (in days) of weak and severe erythema, dry and moist desquamations was assessed. The most sensitive "critical" components of radiation response which are open to modification with the help of radioprotectors--severe erythema and moist desquamation were revealed. Mexamine, cystamine and ionol produce the most marked effect. The value of their protective effect is 48.3; 40.1 and 32.3 units respectively. Skin radioprotectors possessing not less than 50% efficacy can be introduced into practice. A search for new radioprotectors should be aimed at the investigation of agents with the efficacy of a reduction of radiation injuries by 70% and more.

5-Methoxytryptamine↗
PubMed1983

[Scintigraphic semeiotics of the polycystic kidney].

Altogether 78 patients aged 12 to 62 with polycystic kidney disease were examined. Of these, 36 were examined while primary diagnosis was established; 42 patients were observed during treatment. Renoscintigraphy with 131I-hippuran and 99mTc-DTPA angionephroscintigraphy with 99mTc-dimercaptosuccinic acid, 99 Tc-tin-gluconate, 99mTc-cyton and nephroscintigraphy with 107Hg-neohydrine were used. Renoscintigraphy was used to evaluate renal excretory function. It was computerized, 20-25 sequences with 1 min. exposure. Angionephroscintigraphy consisted of 3 stages: (1) indirect radionuclide angioscintigraphy of the kidneys to evaluate the renal blood flow; (2) nephroscintigraphy to evaluate the anatomotopographic condition of the kidneys and the amount of the functioning parenchyma; (3) nephroscintigraphy using a Pinkhol collimator to specify the anatomotopographic condition of the kidneys. Based on angionephroscintigraphy 3 degrees of renal lesion were singled out: mild (43.2% of the cases), moderate (24.3%) and severe (32.5%). In renoscintigraphy moderately expressed unilateral changes prevailed in 49.4% of the cases, pronounced unilateral changes in 8.6%, moderate bilateral changes in 31.3% and demonstrable bilateral changes in 6.5%. In 4.2% of the cases no changes were found on the computerized renograms. The diagnostic value of reno- and angionephroscintigraphy in polycystic kidney disease was 92.6%. The study has shown a high efficacy of radionuclide methods in the evaluation of the process over time, therapeutic results and the elucidation of the familial nature of the disease.

Adolescent↗
PubMed1983

[Radionuclide studies with a dynamic kidney phantom].

Altogether 120 studies with a dynamic kidney phantom (DKP) were conducted permitting one to imitate the normal functioning of the kidneys or different pathological states of the organ. The studies were conducted with the help of a gamma-chamber of MV-9100 type using a computer system SEGAMS (Hungary) and a chronoscope RIKh-5M-01. On completion of the experiment the activity-time curves were plotted characterizing the time course of the passage of a radioactive tracer through phantom cylinders that imitate the kidneys. The results obtained have demonstrated DKP potentialities for the imitation of various renal functional states. Studies with a DKP make it possible to select an optimum regimen for research and to assess the quality of performance of nuclear medical diagnostic equipment.

Computers↗