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Biomedical subjects

E V Kizhaev

Publications and source records attributed to E V Kizhaev.

At least 19 recordsLinked to original sources
PubMed1993

[The mitotic cycle parameters of bone marrow cells after irradiation].

The study was performed of mitotic cycle stage distribution (G1/0, S, G2 + M) by means of flow cytometry in rats irradiated locally and totally and in 25 cancer patients receiving radiotherapy. Radiation effects manifested themselves in diminished percentage of cells in S-stage, in the block G2 + M reflecting the direct affection of myelokaryocytes. Logarithmic dependence of the quantity, of cells synthetizing DNA on radiation dose occurred in the animals in the range 0.5-6 Gy 24 hours after the exposure. Investigation of the patients' sternal puncture biopsies indicated that the proportion of S-stage cells and the value S/(G2 + M) are significant diagnostic markers of more than 1 Gy irradiation 24-48 h after the exposure. For establishing radiation overdosage these parameters proved much more informative than hemocytological indices (myelogram).

Animals↗
PubMed1993

[The clinical picture and treatment of local radiation lesions].

The article gathers a long-term experience in diagnosis and treatment of local radiation injuries in 205 patients, including patients with irradiations caused by accident situation. Relatively good results were obtained during the treatment of severe injuries.

Adolescent↗
PubMed1991

[Experience with combined therapy in lymphogranulomatosis].

The article gathers the experience of therapy for lymphogranulomatosis of 1122 patients during last 12 years, and gives the summary of its immediate results. The only radiation therapy was employed for 11.3% of patients, chemical therapy--for 1.2%, and combined therapy in which both radiation and chemical therapy were used--87%. The simultaneous employment of radiation and chemical therapy led to a considerable reduction of the period of treatment, moreover there were no pronounced depressions in medullary hemoplasty. The further progression of the disease was commonly marked only in the cases with general manifestation of illness and affection of more than two globate glands. It is recommended to continue polychemical treatment for a year after the patient's recovery in order to prevent relapses.

Combined Modality Therapy↗
PubMed1990

[The RX-PLAN--a computer system for planning radiation treatment].

The authors presented a system of radiation treatment design (RT)--RX-PLAN developed at the N. N. Burdenko Main Military Hospital in 1988 on the basis of a PC of DVK-3M type. The use of the PC with a graphic interface made it possible to meet the following specific requirements: input, imaging, processing and output of graphic data and to make an automated working place of low cost for radiologists (a physicist and a physician).

Humans↗
PubMed1980

[Prognostic factors of the probability of the occurrence of complications in the radiation therapy of malignant neoplasms].

The authors present an analysis of the causes of radiation induced complications in 383 patients referred to the Chair of Clinical Radiology from different medical institutions of the country. It was found that under distant gamma therapy, to prevent the development of complications the value of TDF-factor should not exceed 105--110, for the associated radiotherapy--130--140, and that for close focal roentgenotherapy--130--150. In vast majority of patients (95.3%) the complications resulted from surpassing the normal tissue tolerance. To prevent radiation injuries it is suggested to take into consideration the TDF-factor values, while in planning radiotherapy to choose such schedules of irradiation, which preclude any surpassing of the tolerance of normal tissues and organs adjacent to the tumor.

Humans↗