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Biomedical subjects

E V Mikhaĭlovskaia

Publications and source records attributed to E V Mikhaĭlovskaia.

9 recordsLinked to original sources
PubMed1991

[Natural killer cells of different immunological phenotypes (CD16+, CD56+ and CD57+) in the blood of patients with insulin-dependent diabetes mellitus].

The method of flow cytometry employing monoclonal antibodies a Leu 7 (CD57), a Leu 11 (CD16) and a NKH-1 (CD56) was used to examine to content of different subpopulations of natural killer cells in the blood of primary patients with insulin-dependent diabetes mellitus and in healthy subjects. Patients with insulin-dependent diabetes mellitus showed as compared with healthy persons a lower content of natural killer cells carrying all the examined markers, in particular, CD56. The degree of reduction of the number of natural killer cells of different subpopulations is individual for each patient that, possibly, reflects the diversity of causes leading to development of the disease.

Adolescent↗
PubMed1978

[Release of the nucleoli and karyoplasm into the cytoplasm of reticular cells in lymph node cultures].

Successive stages of the process characterizing the release of the nucleoli and part of the nuclei contents into the reticular cell cytoplasm were recorded in the primary cultures of the lymph nodes of albino mice with transplantable leukemia. Comparison of the results obtained with the autoradiographic data pointing to the high proliferative and metabolic activity of the reticular cells permits a suggestion that the recorded phenomenon reflected the secretory function of the stroma cells of the hemopoietic organs at the morphological level.

Animals↗
PubMedDate not supplied

[Cellular interactions in lymph node cultures].

The comparison of the results of the author's own observations based on the tissue culture method, autoradiography and time lapse cinemicrography with the data of literature permits concluding that the lymphoid cells are capable of exchanging biological information through the cytoplasmic bridges arising between them. The data obtained show an active penetration of lymphocytes into the cytoplasm of reticular cells and macrophages.

Animals↗
PubMedDate not supplied

[The evaluation of the mechanism of thrombocytopoiesis from the viewpoint of the phenomenon of emperipolesis].

Cytolytic aggressiveness of bone marrow leucocytes towards megakaryocytes was documented with the aid of a phase contrast Zeitraffer microfilming of alive cells technique. The difference was found between the process above and cell interaction through emperipolesis. The author comes to the conclusion that leucocytes play an active part in platelet production regulation. The data obtained enable new pathognomic methods of treatment to be developed and preventive measures to be devised against blood platelet cytosis involved in the morbid course of quite a number of medical conditions, and further studies to be made.

Animals↗
PubMedDate not supplied

[Emperipolesis (hypotheses and facts)].

This report is dedicated of modern notion about new biological phenomenon which was named emperipolesis in 1956. On the basis of proper data, morphofunctional characteristics of character of concept about existence of "megakaryocytic-leukocytic" type of emperipolesis is substantiated. A hypothesis about phylogenetic unity of emperipolesis and phagocytosis is suggested.

Animals↗
PubMedDate not supplied

[Genomic disorders in the mononuclear blood cells of those who worked in the cleanup of the accident at the Chernobyl Atomic Electric Power Station].

The results of molecular investigations of blood mononuclears from 120 clean-up workers after 7-9 years of Chernobyl accident with the total exposure radiation doses ranging from 5 to 76 cGr are presented. Structural polymorphism of the leukemia associated bcr and ribosomal RNA (rRNA) genes were studied using Southern blot hybridization. Allelic polymorphism of bcr gene with characteristic for leukemia allele distribution was detected in 16.6%. Rearrangements of rRNA genes were observed in 13% of Chernobyl accident clean-up workers.

Alleles↗