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Biomedical subjects

E V Nikushkin

Publications and source records attributed to E V Nikushkin.

At least 19 recordsLinked to original sources
PubMed2006

[The activity of gastrointestinal enzymes in chronic viral hepatitis B and C].

The study was undertaken to evaluate the enzymatic activity of the gastrointestinal tract in patients with chronic viral hepatitis (CVH) B and C. Fecal tests were made in 44 patients. The general pancreatic maldigestion syndrome was observed in 18% of patients with CVH B and C. A direct relationship was found between the content of starch, and indigested muscle fibers, neutral fat, and digested cellulose, which points to the fact that there is a decrease in the pancreatic acinous tissue synthesis of just several enzymes, i.e. generalized pancreatic insufficiency was observed. It is recommended that all patients with CVH should undergo a fecal test whereby the enzymatic activity of the gastrointestinal tract may be, if a certain diet is given, evaluated to prescribe timely enzyme replacement therapy.

Bile Pigments↗
PubMed1998

[Susceptibility of community-acquired pneumonia pathogens to azithromycin].

Two hundred and sixty eight microbial strains were tested for their antibiotic susceptibility. Azithromycin (sumamed) was shown to have an efficient inhibitory action on pneumococci, streptococci and hemophilic bacilli. Doxycycline and gentamicin were not sufficiently active against gram-positive cocci, the same as trimethoprime/sulfamethoxazole which was equally not sufficiently active against hemophilic bacilli. Adequate therapy of bronchopulmonary diseases requires the pathogen antibioticograms.

Adult↗
PubMed1997

[Oxidation in liposomes from egg phosphatidylcholine loaded with L-3,4-dihydroxyphenylalanine (DOPA) and dopamine: mutual effect of components].

Oxidation of egg phosphatidylcholine and catechols (L-3,4-dihydroxyphenylalanine or dopamine) in liposome dispersions was studied. These catechols, encapsulated in liposomes, were shown to decrease the rate of phosphatidylcholine oxidation by factors of 4.9 and 2.6, respectively, at storage in darkness at 4 degrees C. After 40 min of Fe(II)-ascorbate-induced oxidation, the level of malonaldehyde in such liposomes remained constant, while in the empty liposomes, it increased 3,4-fold. Egg phosphatidylcholine protected catechols encapsulated into liposomes from oxidation, and the rate of this oxidation was shown to be substantially lower than that in micellar solutions under the same conditions. Evidently, this can be due to the barrier function of a lipid bilayer.

Dopamine↗
PubMed1996

[Interrelationship between pro-oxidant and immunomodulating properties of vitamin D].

It was shown in experiments on mice that 1.25 (OH)2D3 ingested per os in dose 100 ng during 5 days caused the great increasing of lipid peroxidation (LP) in peritoneal macrophages and spleen cells. The evidence of LP induction is the production of TBA-positive substances in these cells. Linear negative dependence was found between increasing of LP and functional activity of lymphocytes which was evidenced by blast transformation of lymphocytes under effect of concanavalin or mitogen of laconose. Linear positive correlation was shown between level of LP and function of macrophages.

Administration, Oral↗
PubMed1993

[Lipid peroxidation during synaptosome depolarization].

The activity of lipid peroxidation in synaptosomes obtained from rat cerebral cortex during different forms of depolarisation has been studied. Depolarization was induced by synaptosomes' electrostimulation, addition of 33 mM KCl or 1 mM ouabain. Such depolarized synaptosomes were used as a model of nerve ending from epileptic focus. It has been shown that at all cases synaptosomes depolarization was accompanied with increasing in lipid peroxidation products level.

Animals↗
PubMed1993

[Antioxidative activity of drugs used in anticonvulsive therapy].

The influence of medicines used in anticonvulsive therapy: phenobarbital, diphenin, phenazepam and Na-valproate at ascorbate-(ASPOL) and NADP H-(PhPOL) depended lipid peroxidation (POL) in pattern systems (homogenates of rat's brain--HRB, lecithin liposomes-LL) has been studied. It has been established that this medicines do not influence at ASPOL in LL in concentration range of 10-10 M. Phenobarbital (10 M) and Na-valproate (10 M) inhibit ASPOL and PhPOL in HRB in 20-25%. Diphenin (10 M) and phenazepam' 10 M) inhibit both types of POL in HRB in 20-25%. Thus, tested medicines, being not the antioxidants themselves, influence at some components in POL regulating system in nerve tissue, inhibiting this process.

Animals↗
PubMed1993

[The antioxidant system in the dynamic combined treatment of epilepsy patients with traditional anticonvulsant preparations and an antioxidant--alpha-tocopherol].

Examination of 13 patients suffering from generalized epilepsy has shown about 20-25% decreases in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GP) in red blood cells. Out of them 9 patients were treated with the antioxidant alpha-tocopherol (600 mg daily). Prior to alpha-tocopherol treatment all patients showed abnormal electroencephalographic (EEG) changes; 4 weeks later the effects of the antioxidant appeared as positive EEG changes, reduced frequency of epileptic seizures, increased SOD activity and patients' improved general state. Thus, the addition of the antioxidant to the multitherapy of epilepsy enhances antioxidative activity and therapeutical effects.

Adult↗