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E V PRICE

Publications and source records attributed to E V PRICE.

At least 19 recordsLinked to original sources
PubMed1956

Benzathine penicillin G in the treatment of syphilis.

Post-treatment observation of two years' duration has confirmed preliminary data which indicated that a single injection of 2.5 million units of benzathine penicillin G, in early infectious syphilis, produces results equal, if not superior, to those obtained with schedules employing 4.8 million units of procaine penicillin and aluminium monostearate.Preliminary data suggest that a single injection of 2.4 or 2.5 million units of benzathine penicillin G may be inadequate for the treatment of asymptomatic neurosyphilis.Delayed reactions do not appear to be induced by the long-sustained blood-levels following the administration of benzathine penicillin G.Repeated injections of PAM increase the risk of reaction to treatment.

Communicable Diseases↗
PubMed1954

Long-term studies of results of penicillin therapy in early syphilis.

In 1945, the US Public Health Service and co-operating treatment centres began a study of the results of penicillin therapy in a group of syphilis patients selected for intensive post-treatment observation. One objective was to test the hypothesis that patients lapsing from follow-up have the same experience as those remaining under observation, and evidence is presented which indicates that this is the case. The major objective was to evaluate the long-term results of penicillin in early syphilis. At the sixth year following penicillin treatment, satisfactory results were recorded for 98%-99% of the patients with primary and secondary syphilis (including those re-treated). There is no evidence that the cure of syphilis is enhanced by the addition of arsenic and bismuth. Seronegativity rates at the sixth post-treatment year were 81.0% for patients given combined penicillin-arsenic-bismuth therapy, and 80.7% for those treated with penicillin alone, while re-treatment rates were 17.4% and 16.3%, respectively. When cases treated with "adequate" dosage of arsenic and bismuth are analysed by the same statistical method as that employed in evaluating penicillin, the superiority of penicillin is clearly evident. A minimum of 4,800,000 units of penicillin is recommended for the treatment of early infectious syphilis.

Antidiarrheals↗