Biomedical subjects

E V Riumina

Publications and source records attributed to E V Riumina.

5 recordsLinked to original sources

PubMed1993

[Concentration-functional interrelationships in the human alternative complement activation pathway].

The dependence of the rate of human complement mediated lysis of rabbit erythrocytes on concentrations of factors B and D of the alternative pathway is characterized by saturation kinetics. At low B and D concentrations no lysis occurs until certain "threshold" concentrations of the respective factor are reached. The type of dependence of the hemolysis rates on the C3 concentration is wavelike, i.e., at definite C3 concentrations the erythrocyte lysis is inhibited. It has been supposed that C3 not only mediates the complement-dependent hemolysis but also plays a prominent role in the self-regulation of this process.

Animals↗

PubMedDate not supplied

[The action of karbogal on the complement system under model conditions and in an animal experiment].

The influence of dimethylperfluorocyclohexane (carbogal) on the hemolytic activity of human blood serum complement was studied in vitro. It has been show that different effects of carbogol on the complement depend on the serum lipid composition. Endotracheal administration of carbogal to rats results in a significant reduction of complement activity in the animal's blood. Significant changes in the hemolytic activity of the complement recorded 21 days after the endotracheal administration of the compound are, probably, associated with the complement depletion after its activation by carbogal particles or with disorders in the complement component synthesis by macrophages.

Animals↗

PubMedDate not supplied

[The effect of plasmin on complement in human blood serum].

Plasma exhibited the dose-dependent inactivating effect on human blood serum hemolytic complement both in classic and alternative pathways. Negative correlation (r = -0.8) was found between the rate of complement inactivation and content of C3 component. Plasmin appears to hydrolyze mainly the C3 component of complement as a result of which hemolytic activity of complement is decreased.

Blood↗

PubMedDate not supplied

[Structure and properties of the complement system proteinases].

Biochemical aspects of enzymes of the complement functioning are presented. Proteolytic, esterolytic and amidolytic characteristics of the complement components which are enzymes in their nature as well as the structure and properties of complex proteases of the activated complement are analyzed.

Amides↗

PubMedDate not supplied

[Activity of the complement system in blood serum of dogs after treatment of acute necrotic pancreatitis with boiled pancreatic juice].

The investigations were conducted on 14 dogs. To assess the blood serum complement system, the erythrocyte lytic rate of a rabbit (RE) and a sheep (SE), the hemolytic capacity of the complement system against rabbit (RH) and sheep (SH) was measured. In acute necrotic pancreatitis, no changes in SE and SH were revealed either in the control and experimental animals. RH was decreased both in the control and experimental animals. Lower RE was found only in the controls untreated with boiled pancreatic juice. It can be suggested that in the controls the decrease in the parameter RE that characterized the activity of the complement system is associated with the emergence of complement inhibitors, which did not take place when the boiled juice was given. Preventing the complement inhibitors from forming, pancreatic juice is likely to be able to diminish the body's endogenous intoxication which is a cause of death in acute necrotic pancreatitis. This may be suggested by the higher survival of the animals and lower relative extent of pancreatic acinar tissue necrosis after boiled pancreatic juice treatment of acute necrotic pancreatitis.

Animals↗