PubMed Health⌕ Search

Biomedical subjects

E V Sørensen

Publications and source records attributed to E V Sørensen.

At least 19 recordsLinked to original sources
PubMed2000

[Transportation of patients with acute myocardial infarction].

The aim of this study was to describe the results and experiences from a local hospital concerning transports with patients with acute myocardial infarction to primary PTCA. Our material includes 27 patients who had primary PTCA. There were no complications during the transports. None of the patients had hypotension or arrythmia requiring treatment during the transports. One patient had ventricular fibrillation before the transport. None of the patients died during the transports. Two patients died in the period following PTCA. The transport delay was 1 hour and 40 minutes on average. Future randomized studies like DANAMI 2 will show if PTCA with delayed treatment, or immediate thrombolysis, give better results for the patient.

Adult↗
PubMed1993

Renal effects of xamoterol in patients with moderate heart failure.

The acute renal effects of xamoterol, a partial beta 1-agonist, were studied in 12 patients with congestive heart failure (NYHA II-III) in stable condition on diuretic therapy for at least 6 weeks. Each patient was given a single intravenous infusion of xamoterol (0.2 mg/kg) or placebo in random order 2 weeks apart. Using constant infusion and lithium clearance techniques, clearance and excretion measurements were made in the supine position at 30- to 60-min intervals before, during, and up to 6 hours after infusion. Blood pressure, heart rate, renal plasma flow, glomerular filtration rate, and urinary flow rate remained unchanged, but xamoterol lowered sodium excretion by 30% (p < 0.05). The decrease started 120 minutes after infusion. Proximal reabsorption of sodium increased after xamoterol infusion, whereas plasma values of aldosterone and angiotensin II were unaffected. It is concluded that the acute renal effects of xamoterol imply an impaired sodium excretion determined by the tubular actions of the drug. The present results suggest that xamoterol may aggravate one of the important abnormalities intrinsic to the pathology of congestive heart failure. These findings are in contrast to the beneficial effects of xamoterol demonstrated in many clinical trials where xamoterol was given orally for a longer period.

Aged↗
PubMed1991

Comparison of the effects of xamoterol, atenolol and propranolol on breathlessness, fatigue and plasma electrolytes during exercise in healthy volunteers.

The influence of clinical doses of drugs that affect beta-adrenoceptors has been examined on heart rate, blood pressure, duration of exercise, and on electrolyte concentrations (Na, K, Ca and Mg) during recovery from exercise in healthy volunteers. The drugs used were a beta 1-adrenoceptor antagonist atenolol, a nonselective beta-adrenoceptor antagonist propranolol, and a cardioselective, partial beta 1-adrenoceptor agonist with 43% ISA activity, xamoterol. The duration of exercise was smaller on propranolol. Maximum exercise heart rate and blood pressure were reduced significantly by propranolol and atenolol. Xamoterol reduced maximum exercise heart rate and had no effect on blood pressure. The degree of breathlessness and fatigue revealed no differences between treatments. Recent evidence has suggested an association between hyperkalaemia and hypomagnesaemia with an increase in the occurrence of arrythmias following acute myocardial infarction. Exercise-induced hyperkalaemia has been suggested as a factor in sudden death. The results confirmed a rise in serum potassium during exercise and attenuation of the fall during recovery under beta-adrenoceptor blockade. Xamoterol was no different from placebo in these respects. Exercise also produced a rise in magnesium levels and during recovery the level fell below baseline. Both these effects were attenuated by propranolol. Calcium levels were not affected by any of the treatments.

Adrenergic beta-Agonists↗
PubMed1990

Effects of positive inotropic drugs on the frequency of contraction of the isolated atria: influence of dose regimen and age.

The dose-activity relationship of various positive inotropic drugs has been investigated in the spontaneously beating right atria of the rat. The influence of dose regimen and age has been evaluated. There is a significant difference between the maximal response of single and cumulative dose experiments with amrinone (P less than 0.05) and dobutamine (P less than 0.001) in animals aged 2 months and in dopamine (P less than 0.001) in animals aged 4 months. The maximum response is lowered significantly with age for isoprenaline with single (P less than 0.05) and for dopamine and dobutamine with cumulative dosing (P less than 0.001). In the single dose study the response is achieved within 4 min. for isoprenaline, noradrenaline, dobutamine, xamoterol and amrinone, but not until after 14 min. for prenalterol. It is concluded that both age and methods used in the study of pharmacodynamics are important. Thus when comparing effects the use of the same method and tissue from rats of the same age is necessary.

Aging↗
PubMed1989

Long-term efficacy of xamoterol (a beta 1-adrenoceptor partial agonist) in patients with mild to moderate heart failure.

This study was designed to assess the efficacy of xamoterol in 14 patients with mild to moderate heart failure over a period of 18 months. A beneficial effect on exercise capacity and a lowering of heart rate on exercise was sustained, and ejection fraction did not change, although some deterioration may be expected over this length of time in patients with heart failure. Xamoterol is safe and effective, and its benefits are maintained over at least 18 months.

Adrenergic beta-Agonists↗
PubMed1989

Pharmacodynamics of BAY K 8644 alone and in combination with dobutamine in the isolated rabbit heart.

The haemodynamic effects of the Ca-agonist BAY K 8644 alone and in combination with the selective beta-I-adrenoceptor agonist dobutamine were studied in the isolated rabbit heart. BAY K 8644 produced a concentration-dependent increase in contraction amplitude and shortening velocity, oxygen consumption and heart rate. In combination with a small fixed concentration of dobutamine (40 nM), Bay K 8644 produced similar alterations. When Bay K 8644 was infused at a fixed concentration (38 nM), dobutamine likewise produced similar increments in contraction amplitude, shortening velocity and heart rate, whereas oxygen consumption was considerably argumented. Both BAY K 8644 and dobutamine showed definite positive inotropic effects in the isolated rabbit heart. Combination of the two drugs did not yield a stronger positive inotropic effect than that seen on single drug administration, and oxygen consumption was even increased.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethy↗
PubMed1988

Subcutaneous fat necrosis in pancreatic disease. A review and two new case reports.

Subcutaneous fat necrosis is a rare and often overlooked sign of pancreatic disease. It is manifested in painful subcutaneous erythematous nodules, often found on the legs. The histopathological finding is pathognomic. Therefore, correlation of clinical manifestations with histopathological and laboratory findings may be helpful in recognizing some disorders of subcutaneous fat. Despite several studies, the cause of metastatic fat necrosis is unknown. I describe the syndrome, review the literature, and report two new cases.

Fat Necrosis↗