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E V Selezneva

Publications and source records attributed to E V Selezneva.

11 recordsLinked to original sources
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Correlates of sequential elements of bimanual behavior in the neuronal activity of the neostriatum in monkeys.

Neuron spike activity was recorded in the putamen of monkeys trained to perform bimanual operant behavior consisting of nine separate steps. Neuronal reactions were present at all steps: in 52-62% of cases during movement, and in 27-36% of cases during responses to the trigger and conditioned signals and as the monkeys decided which was the working hand. The proportion of inhibitory responses to the trigger stimulus was 9%, while inhibitory reactions accounted for 68% of reactions during hand movement in response to the conditioned signal, 33% of reactions when this same hand was used to collect food reinforcement, and 33% of reactions during simultaneous movement of both hands. Reactions significantly differentiating between right- and left-sided tasks were seen at all stages of working-hand decision-taking and in reactions to the signal indicating the correctness of the selection, but were not seen for reactions to the conditioned signal or for activity accompanying movements of one of the animal's hands. These data provide evidence indicating that each step of the complex operant behavior, individual systems of putamen neuronal reactions were created with qualitatively different integral sensitivity to instantaneous behavior.

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Involvement of striatum (putamen) neurons in motor and nonmotor behavior fragments in monkeys.

Putamen neuron spike activity associated with motor and nonmotor functions was studied in monkeys trained to behavioral programs consisting of a series of sequential actions. In general, each putamen neuron was activated during particular behavior fragments. The association of each individual neostriatal neuron with particular behavioral fragments was not constant. When the animal performed a different version of the same program (using different conditioned signals, right- or left-sided tasks, correct or erroneous performance), the neuron could lose its association with the animal's action and become involved in a different action to which it had previously produced no response. Thus, putamen neurons could demonstrate different functional modalities in different versions of the same actions. The use of additional versions of the given program always led to increases in the numbers of behavior fragments during which there were changes in the spike activity of the neurons of interest. This effect was significantly stronger in motor fragments of the program than in nonmotor fragments. These results show that putamen neurons do not have any defined specialization and have different functional modalities when the animal performs different versions of the same action. The nature of putamen neuron involvement in sensory-cognitive processes was more stable than in the organization of motor responses.

Action Potentials↗
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Collective responses of neostriatal (putamen) neurons during alternative behavior in monkeys.

A monkey (Macaca nemestrina) was trained to perform a behavioral program consisting of the selection and execution of a defined sequence of actions according to a visual conditioned signal. Discriminant analysis was used to evaluate the parameters of the collective activity of six simultaneously recorded putamen neurons. The collective activity of the neurons showed significant differences associated with execution by the monkey of left- and right-sided tasks. These differences were seen to be quite consistent in different groups of neurons. Despite the fact that putamen neurons were involved in the performance of nine separately analyzed fragments of the program, differences were seen in two of these: at the moment of taking the decision relating to the direction of movement, and after its completion when a signal indicating the completed result was presented, independently of whether the animal selected the side for the action correctly or incorrectly. In the case of erroneous decisions, the response mosaic differed from that obtained for correct decisions; however, differences due to previously taken decisions regarding the side of action were preserved. These differences were greater at the point of program completion than at the moment of deciding the direction of movement.

Action Potentials↗
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[Reaction of striatal (putamen) neurons on motor and non-motor fragments of behaviour in monkeys].

Each putamen neuron responded to several fragments of a behavioural programme, the pattern of such connections being not constant. The response could disappear in a different variant of the behavioural programme while a response to another fragment could occur. Therefore additional variants of the programme were followed by an increase in number of functional modality of a neuron. This was more obvious in motor fragments of the programme. The data obtained suggest that the putamen neurons have no particular specifics, and so involvement of its units in sensory-cognitive processes seem to be more stable than in organisation of movements.

Action Potentials↗
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[Collective reactions of neostriatum (putamen) neurons to alternative behaviour in monkeys].

Significant differences were found in collective unit activity of 6 neostriatum neurons associated with performance of either left- or right-sided task by monkeys: at the moment of decision-making regarding the direction of the movement, and after its completion, irrespective of correctness of the choice. The differences at the moment of the programme completion were significantly greater than at the moment of the decision-making.

Action Potentials↗