Biomedical subjects

E V Sytina

Publications and source records attributed to E V Sytina.

3 recordsLinked to original sources

PubMed1994

Cell differentiation in vitro and the expression of Oct-2 protein and oct-2 RNA.

Expression of the oct-2 gene was studied in mouse tissues and during in vitro differentiation of embryocarcinoma PCC4, mouse neuroblastoma Neuro2A and NB41A3 cells in the presence of retinoic acid (RA) or 1% DMSO. oct-2 mRNA is characterized by a complex pattern and exists in both poly(A)+ and poly(A)- forms. oct-2 mRNA was found in many cell lines, whereas Oct-2 protein was detected only in some of these cells. oct-2 expression also changed during cell differentiation. The cell differentiation is likely to be controlled not only at the gene transcription level, but also at the level of regulation of nuclear transcription factor activity. Such a regulatory mechanism would provide for a finer regulation of cell differentiation.

Animals↗

PubMedDate not supplied

[Oct-1 transcription factor--plasticity and polyfunctionality].

The problem considered is how one transcription factor controls numerous processes in the organism. The mechanisms determining the multiplicity of Oct-1 functions are described.

Alternative Splicing↗

PubMedDate not supplied

[Expression of the Oct-2 protein during cell differentiation in vivo and in vitro].

The expression of an Oct-binding protein Oct-2 was studied during differentiation of three cell lines. Two inductors were used in our experiments: retinoic acid and DMSO. It was shown that all these cells have heterogeneous population of Oct-2 mRNA. Under differentiation the pattern of Oct-2 RNA and expression of active Oct-2 proteins was changed.

Animals↗