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Biomedical subjects

E V White

Publications and source records attributed to E V White.

14 recordsLinked to original sources
PubMed1984

Mass spectrometry of 2-substituted-4-arylthiazoles. 3--Identification of microsomal nitroreduction products by mass spectrometry.

The electron impact mass spectra of the chemical carcinogens 4-(4-nitrophenyl)-2- methylaminothiazole , 4-(4-aminophenyl)-2- methylaminothiazole and 4-(4-aminophenyl)-2- aminothiazole were studied. The 4-(4-amino-phenyl)-2-substituted thiazoles were isolated from the anaerobic microsomal reduction of their respective 4-nitrophenyl analogues. Microsomes prepared from rat and rabbit kidney tissues were used. The identity of the reduction products were established by chemical synthesis and mass spectrometry. The mass spectrometric fragmentation of the nitro derivative shows prominent ions arising from the loss of the nitro group, ring enlargement of the thiazoles, and the phenylthiirene ion resulting from 1,2-cleavage of the thiazole ring. In the 4-(4-aminophenyl)-2-substituted amino derivative prominent ions result from the preferential 1,2-cleavage of the thiazole ring to give the common 2-(4-aminophenyl) thiirene ion and subsequent fragmentation of this ion.

Aniline Compounds↗
PubMed1977

A halfway house for mentally ill offenders.

The authors describe the resocialization of recovering mentally ill male offenders through the halfway house program to which they were released. A number of guiding principles are discussed in connection with the care of this high-risk population. Partial residence for those about tp be discharged from the hospital was one feature of the program. Evaluation of the program after three years showed a lower than average rate of recidivism and relatively low operating costs; in addition, it appeared that predictions regarding possible dangerousness can be made with greater confidence when halfway house residence is part of the treatment plan for this type of population.

Aftercare↗