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Biomedical subjects

E Vadot

Publications and source records attributed to E Vadot.

At least 19 recordsLinked to original sources
PubMed1996

Identification of a cat eye syndrome using DNA sequence dosage analysis.

We report here the detection of a Cat Eye Syndrome (CES) in a woman who does not exhibit the related phenotype, due to intensive surgery. The analysis of her karyotype reveals a small supernumerary bisatellited chromosome likely to correspond to a fragment of chromosome 13, 15, 21 or 22 on banding analysis. Southern blot of genomic DNA of this patient and her parents hybridized with probes specific of these chromosomes, revealed a DNA amplification of the 22q11 region for the patient, likely to correspond to a CES.

Abnormalities, Multiple↗
PubMed1990

[Current etiological aspects of papilledema].

Twenty-eight patients with papilloedema have been observed on twenty-thousand patients. In one third of the cases, they were associated with an hypertensive retinopathy. Another third was symptomatic of an expansive intra-cranial process. Otherwise, we only find a papilloedema in one case of eight with an expansive intra-cranial process. If a lot of them stay idiopathic and can regress without complication, it is necessary to look after them regularly, the secondary discovery of a cerebral tumor is not exceptional at all.

Brain Neoplasms↗
PubMed1989

[Retinitis and chorioretinitis].

Retinitis and chorioretinitis (uveitis) are usually due to an infection. By far their most frequent cause is a late recurrence of congenital toxoplasmosis, a disease which can be diagnosed clinically and which, in the absence of therapeutic errors, generally follows a favourable course. Among other types of uveitis, cytomegalovirus retinitis is fairly frequent in immunocompromised subjects.

Chorioretinitis↗
PubMed1989

[Uveitis of viral origin].

Most well-defined viral uveitis cases are due to herpes viruses. Thus, HSV and VZV may cause a chronic anterior uveitis, usually with other characteristic signs. Cytomegalovirus causes a necrotic and haemorrhagic retinitis in immunosuppressed patients. Acute retinal necrosis also seems to be caused by members of the herpes virus family. Many cases of intraocular inflammation have been described in association with viral diseases, but this does not necessarily imply the presence of virus in the eye.

Cytomegalovirus Infections↗
PubMed1989

[The frequency of acute glaucoma crises. Implications for the detection of the risk of angle-closure].

Over a 5 year period 61 patients with acute angle closure glaucoma have been registered in Department Savoie (323,675 inhabitants). The annual incidence is therefore 3,8/100,000. The mean age is 70 years. In each age class the incidence for women is approximately 3 times that for men. The geographic distribution parallels that of the whole population. There is no seasonal variation of incidence. 9 cases only (15%) could be considered as drug-induced. The prevalence of shallow anterior-chamber (less than 2.2 mm) and Van Herrick sign in the general population shows that the latter sign implies a 50% risk of acute angle closure, and is therefore well suited for the detection of patients at risk.

Acute Disease↗
PubMed1987

Eye diseases and proteins controlling visual transduction.

Retinal S antigen is a soluble protein found in abundance in photoreceptor cells. Immunization of laboratory animals with this antigen in adjuvant induces experimental autoimmune uveoretinitis. Cellular immunity plays a major role in this condition. Autoimmune responses toward retinal S antigen are often observed in patients with retinal inflammatory disease, however, these responses are usually secondary to local tissue damage. The S antigen is identical to the 48 K protein characterized in rod outer segments by its light-dependent binding to the disk membrane in the presence of ATP. This protein binds specifically to photoexcited and phosphorylated rhodopsin, and quenches the activity of the light-dependent cGMP-phosphodiesterase, most probably because it competes with transducin. There is no evidence for any direct inactivation of phosphodiesterase by 48 K protein. In view of the numerous similarities between the photoreceptor enzyme cascade and hormone-activated cyclase systems, a related protein could be involved in the desensitization of hormonal systems.

Animals↗
PubMed1987

[Epidemiological approach of the role of Chlamydiae in uveitis].

A serologic study on 48 uveitis cases is reported. Antibodies to Chlamydiae trachomatis are significantly more prevalent in acute anterior uveitis than in healthy controls or in other uveitis. This finding does not necessarily imply a direct pathogenic role for Chlamydiae in acute anterior uveitis. A common genetic predisposition to Chlamydia infection and acute anterior uveitis, with particular reference to H.L.A. B 27 antigen, is a more likely explanation.

Acute Disease↗
PubMed1986

[Incidence of allergy to eyedrops. Results of a prospective survey in a hospital milieu].

An estimation of the frequency of allergic contact reactions to eyedrops was obtained by means of a prospective study on hospitalized patients. The incidence of cases with a positive patch test was 6% during hospital care. The drugs blamed were atropine (allergic contact reaction in 3% of treated patients), phenylephrine (risk 2.6%) and neomycin (risk 1.7%). The preservatives were not involved in any case. More than half of the patients had a previous history of eyedrop contact allergy, but they only rarely knew which drug was involved. The systematic use of patch tests to identify the allergenic drug(s), the accurate information of the patient and the parcimonious use of allergenic drugs, particularly of antibiotic eyedrops, are simple measures which should decrease notably the incidence of allergic contact reactions.

Adult↗