PubMed Health⌕ Search

Biomedical subjects

E Vermes

Publications and source records attributed to E Vermes.

24 records · Page 2Linked to original sources
PubMed1997

[Myocardial infarction in a pregnant woman during salbutamol therapy].

The authors report the case of a 31 year old woman at 30 weeks' gestation who developed a non-Q wave postero-lateral myocardial infarction during treatment with salbutamol. There were no complications and delivery took place at term normally. Coronary angiography was performed 3 months post-partum and was normal: the Methergin test was negative. Myocardial ischaemia occurring during treatment with a beta-2 mimetic in pregnancy is rare and hardly ever progresses to myocardial infarction. The usual mechanism of ischaemia is an imbalance of myocardial oxygen demand and supply. Myocardial oxygen consumption is naturally increased during pregnancy and excess intracellular calcium secondary to the beta-1 stimulation occurring with the use of beta-2 mimetic drugs further aggravates matters. This hypothesis raises the question of the value of calcium inhibitors in these forms of myocardial ischaemia.

Abortion, Threatened↗
PubMed1996

[Pulmonary embolism and thrombus trapped in a patent foramen ovale. Cure by heparin therapy].

The authors report the case of a 84-year old patient admitted to hospital for pulmonary embolism. The diagnosis was made by ventilation and perfusion pulmonary scintigraphy. Transthoracic echocardiography was performed routinely and showed a thrombus wedged across a patient foramen ovale, confirmed at transoesophageal echocardiography. Spiral thoracic computerised tomography showed thrombus in the two main pulmonary arteries and the inferior vena cava. Thrombolysis or thrombectomy under cardiopulmonary bypass, was thought to carry an excessive risk at that age and with the left-sided position of the thrombus. The alternative was therefore anticoagulation which led to dissolution of the thrombus without recurrence of pulmonary embolism or cerebrovascular accident.

Aged↗
PubMedDate not supplied

Early effect of cyclophosphamide on oncogene expression in vivo.

Cyclophosphamide (CP) is a widely used chemotherapeutic drug, with proven carcinogenic effects. Secondary tumours induced by CP are kidney tumours in humans and haemopoietic malignancies in rodents. Previous experiments have shown its effect on H-ras, c-myc and p53 gene expression in long term in vivo experiments. Our model was developed to analyse the events in the first 24 hours after the administration of CP in short term experiments. The expression of Ha -ras, c-myc and p53 was investigated in the target organs during and up to 24 hours after the administration, at 0.25, 0.5, 1, 6, 12 and 24 h. Since the majority of CP-induced tumours are leukemias and lymphomas in the CBA/Ca mouse model, RNA was obtained from the thymus and the spleen. The results show that p53 is strongly expressed in the thymus during the focused period. On the other hand, the samples were subjected to in situ hybridisation and compared with the results of in situ hybridisation of lung and liver samples. Comparing the results of total RNA and in situ hybridisation should prove useful if the total RNA signal is too weak or not detectable at all. The in situ hybridisation picture showed many positive cells without high expression of oncogenes. Further flow-cytometric studies are necessary to provide a full explanation of the mechanism of CP induced changes.

Animals↗