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Biomedical subjects

E Vieth

Publications and source records attributed to E Vieth.

4 recordsLinked to original sources

[Driving fitness of female headache patients in tests of traffic medicine--a psychotechnical investigation].

To detect differences in psychophysical performance during pain attacks and pain-free intervals, 30 female patients aged 21 to 58 years and suffering from attacks of headache were investigated intraindividually by means of established test methods (attention quotient according to Grüner, motorial accomplishment series according to Schoppe and achievement testing device). The patients were randomized and assigned either to Group A (first test while having pain) or Group B (first test without pain). The patients were also asked to assess the intensity of their headaches. The hypothesis that "headaches do not impair psychophysical performance" was refuted by the significant results obtained in all tests, the observed deficits concerned predominantly achievements in the field of concentration, achievements which are also required for operating a motor vehicle.

Adult↗

Fitting piecewise linear regression functions to biological responses.

An iterative approach was achieved for fitting piecewise linear functions to nonrectilinear responses of biological variables. This algorithm is used to estimate the parameters of the two (or more) regression functions and the separation point(s) (thresholds, sensitivities) by statistical approximation. Although it is often unknown whether the response of a biological variable is adequately described by one rectilinear regression function or by piecewise linear regression function(s) with separation point(s), an F test is proposed to determine whether one regression line is the optimal fitted function. A FORTRAN-77 program has been developed for estimating the optimal parameters and the coordinates of the separation point(s). A few sets of data illustrating this kind of problem in the analysis of thermoregulation, osmoregulation, and the neuronal responses are discussed.

Algorithms↗

Are black-box models of thermoregulatory control obsolete? The importance of borrowed knowledge.

Black-box models of thermoregulatory control have gained increasing importance in describing the properties of the biological thermostat and in devising working hypotheses for further experimental analysis. Incorporation of knowledge acquired independently from the systems analysis approach into black-box models of thermoregulation has proven useful in improving their predictive ability. The pieces of "borrowed knowledge" from independent analysis which are currently utilized in devising models of homeothermic thermoregulation comprise: the proportional control property of the biological thermostat, the Sherringtonian principles of synaptic interaction, the multiple input control of thermoregulatory effectors with differential input-effector coupling, the lack of significant thermosensory contribution from the hypothalamus in birds, the existence of warm and cold receptors and the thermal characteristics of their responses, and the Q10-type temperature dependence of temperature signal transmission within the central nervous system. Consideration of these pieces of borrowed knowledge has resulted in black-box models of temperature regulation in which explicit set-point terms are avoided.

Animals↗