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Biomedical subjects

E Vijayan

Publications and source records attributed to E Vijayan.

At least 73 records · Page 4Linked to original sources
PubMed1977

Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH).

Since both TRH and somatostatin (SRIF) are localized to the ventromedial hypothalamic nucleus, a region known to be involved in control of food intake, the possibility that these peptides might alter food intake was evaluated. The peptides were dissolved in 0.9% NaCl and injected into the 3d ventricle in a volume of 2 micron1 in animals bearing 3d ventricular cannulae. Food and water had been removed from the cages the night before and the intake was measured at 1 and 6 h after injection. Control injections of 0.15M NaCl or glutathione (3 nmoles) had no effect on food or water intake. At a dose of 3 nmoles, LHRH, SRIF, and TRH suppressed water intake alh. Lowering the dose of LHRH and SRIF to 0.6 nmoles led to loss of this inhibition but the suppressive effect of TRH, which was more pronounced at the higher dose than that of the other two peptides, persisted. Lowering the dose of TRH to 0.3 nmoles led to loss of the inhibitory effect. The dose of 3 nmoles of LHRH did not suppress food intake but this dose of both SRIF and TRH had a significant suppressive effect on food intake at 1 h. There was no suppressive action of a lower dose of 0.6 nmoles of SRIF, but TRH was still effective to suppress food intake at this dose. A dose of 0.3 nmoles of TRH had no effect on food intake. It is suggested that TRH, and possibly SRIF may play a physiological role in control of food intake, perhaps by altering the neural activity within the ventromedial nucleus.

Animals↗
PubMed1975

H3-phenylalanine incorporation into protein in the pituitary, hypothalamus and cerebral cortex of male rats during postnatal development.

Incorporation of H3-phenylalanine and concentration of protein in the anterior pituitary gland (APG), hypothalamus and cerebral cortex of male rats have been studied during postnatal development from day 21 to 120. APG and hypothalamus showed significantly higher rate of amino acid uptake and protein synthesis during the prepubertal phase, decrease at puberty and an age dependent variation thereafter. Protein concentrations and amino acid incorporation in the APG and hypothalamus are possibly influenced by the higher circulating levels of androgens during sexual maturation in marked contrast to their lack of effect on the cerebral cortex.

Age Factors↗