Biomedical subjects
Publications and source records attributed to E W Hein.
Allergy is responsible for many problems in the pediatric age-group. At times the most difficult job for the physician is to determine if the patient is indeed allergic and, if so, to what. Allergy skin testing remains the first choice for diagnostic study. Treatment consists of avoiding the offending allergen if possible, controlling symptoms with appropriate medication, and using immunotherapy if indicated.
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Four hundred and thirty-four children diagnosed as asthmatics in an emergency room were studied to evaluate the usefulness of treatment in a holding unit to minimize hospitalizations for the treatment of status asthmaticus and to facilitate early institution of effective therapy. Three hundred and twenty-eight children (76%) improved sufficiently following subcutaneous injections of epinephrine to be sent home. Of the remaining 106 patients, 71 were discharged after further therapy. Four of the patients discharged returned within one week requiring further therapy and eventual admission to the hospital. The average cost of hospitalization for 35 patients eventually admitted was more than five times the average cost of care for those treated only in the holding unit, and hospitalization for 24 hours would have more than doubled the cost of care for those discharged from the holding unit.
Each of 12 asthmatic children received a single dose of Theolair, 5 mg/kg, a single dose of Theolair SR, 10 mg/Kg, or both Theolair, 3 mg/Kg and Theolair SR, 10 mg/Kg on three separate days. Administration of both preparations together was followed by serum theophylline concentrations significantly higher than Theolair alone at 2 or 12 hours and significantly higher than Theolair SR alone at every time except six hours. This method of theophylline administration may be useful in the asthmatic patient who requires medication only intermittently.
The effects of administration of single doses of 10 mg/kg of two sustained release theophylline preparations were compared in a double-blind, crossover study in eight asthmatic children. Serum theophylline concentrations were maintained well for 8-10 hours after administration of Theolair SR and 10 and 12 hours after administration of single doses of Theo-Dur.