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Biomedical subjects

E W Lupton

Publications and source records attributed to E W Lupton.

15 recordsLinked to original sources
PubMed1992

The obstructive diuresis renogram: an appraisal of the significance.

We managed expectantly 23 patients with renal pelvic dilatation and unilaterally obstructive diuresis renograms. Serial renograms showed changes in ipsilateral relative renal function in 8 kidneys (4 deteriorated). Pressure-flow studies demonstrated low pressures on perfusion of 8 kidneys. Eight patients eventually required pyeloplasty, mostly for loin pain. Therefore, serially obstructive diuresis renograms can be associated with preserved renal function, with high pelviocaliceal compliance being a possible explanation.

Adolescent↗
PubMed1990

Mixed mesonephric adenocarcinoma and transitional cell carcinoma of the bladder.

Mesonephric type adenocarcinoma is a very rare tumour in the bladder and bears a resemblance to nephrogenic adenoma. We report (to the best of our knowledge), the first case where the tumour was partly composed of mesonephric and partly of poorly differentiated transitional cell carcinoma. Staining for alpha 1-antitrypsin and carcino-embryonic antigen were positive in the mesonephric component but negative in the transitional cell carcinoma.

Carcinoma, Transitional Cell↗
PubMed1990

Effect of bladder filling on upper tract urodynamics in man.

A group of 21 patients with hydronephrosis but normal bladders had their upper urinary tract pressures monitored while perfusing the affected kidneys through a fine bore nephrostomy tube, initially with the bladder on free drainage and subsequently during bladder filling. In 7 patients the renal pelvic pressures were altered by bladder filling and loin pain was reproduced in 4. It was concluded that with high upper tract flow rates, vesical filling can affect upper tract dynamics and this should be considered when evaluating patients with loin pain or potential obstructive uropathy.

Female↗
PubMed1987

Compliance studies, pressure flow measurements and renal function assessment in patients with upper urinary tract dilatation.

The compliance index was determined in 38 hydronephrotic kidneys undergoing diagnostic pressure flow studies. A good correlation was found between this index and the result of the pressure flow study but no consistent relationship was observed between the index and relative renal function as assessed by renographic means. The ability of the compliance index to predict functional deterioration in patients with hydronephrosis must be questioned.

Adult↗
PubMed1986

Bladder smooth muscle dysfunction in patients with irritable bowel syndrome.

Urodynamic studies were carried out on 30 patients with irritable bowel syndrome and 30 matched controls. Fifty per cent of the irritable bowel patients compared with only 13% of the control group had evidence of bladder dysfunction (p = 0.006). In the irritable bowel group detrusor instability was observed in 10 patients compared with only one control subject (p = 0.008). A steep cystometrogram occurred in five irritable bowel patients and three controls (NS). Detrusor instability was most common in patients with a bowel habit characterised by alternating constipation and diarrhoea. This is the first study to provide objective evidence that patients with irritable bowel syndrome may have a disorder of smooth muscle or its innervation that is not confined to the gastrointestinal system.

Adult↗
PubMed1985

A comparison of diuresis renography, the Whitaker test and renal pelvic morphology in idiopathic hydronephrosis.

Diuresis renography and the Whitaker test are established methods of diagnosing obstruction in dilated renal pelves. These techniques have been compared in 36 patients with radiologically demonstrated idiopathic hydronephrosis and evaluated, where possible, against renal pelvic morphological features. The agreement between the results of the tests was as follows: diuresis renography/Whitaker test 67%; diuresis renography/renal pelvic morphology 74%; Whitaker test/renal pelvic morphology 58%. Both diuresis renography and the Whitaker test are indicated in some cases of idiopathic hydronephrosis.

Diuresis↗
PubMed1985

Pressure changes in the dilated upper urinary tract on perfusion at varying flow rates.

The conventional Whitaker test assesses the pressure response to a constant perfusion rate of 10 ml/min. Twenty-eight kidneys were perfused at increasing flow rates up to 20 ml/min. Nine became obstructed at rates of 12 to 20 ml/min. The feasibility of such a high urine output has been tested and confirmed. The standard Whitaker test may therefore miss some cases with potentially obstructive hydronephrosis, the effects of which may be deleterious to renal function.

Adolescent↗
PubMed1979

Diuresis renography and the results of pyeloplasty for idiopathic hydronephrosis.

Eighty-six kidneys in 82 patients have been assessed by diuresis renography after pyeloplasty. A non-obstructed diuresis renogram was found in 64% of kidneys. Ninety per cent of patients were clinically improved by surgery and 51% of cases studied had improved urographic features. Thirty kidneys (29 patients) were assessed both before and after pyeloplasty. An improvement in the diuresis renogram was found in 89% of cases postoperatively. Standard renography demonstrated improved drainage in only 33% of kidneys. These findings are discussed in relation to the value of diuresis renography after pyeloplasty.

Adolescent↗
PubMed1979

Diuresis renography and morphology in upper urinary tract obstruction.

The results of a combined study of 25 patients with idiopathic hydronephrosis are presented. Diuresis renography was performed pre-operatively and surgically removed specimens of the renal pelvis and ureter were examined by light and electron microscopy. There was good correlation between the results of these 2 methods of assessment which have defined 2 broad categories of patients with renal pelvic dilatation. These findings are discussed with particular reference to the clinical value of diuresis renography.

Adolescent↗
PubMedDate not supplied

Squamous-cell carcinoma of the proximal colon: report of a case and review of the literature.

A case of an undoubted squamous-cell carcinoma arising at the hepatic flexure in the colon of a middle-aged man is reported. Review of the literature and exclusion of cases not strictly comparable suggest that pure squamous-cell carcinoma of the colon is rare, this being only the fifteenth such tumor reported, and only the second recorded case of such a tumor of the hepatic flexure. Possible pathogenesis is suggested.

Adult↗