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Biomedical subjects

E W Maynert

Publications and source records attributed to E W Maynert.

18 recordsLinked to original sources
PubMed1978

Effect of intracisternal 6-hydroxydopamine on seizure susceptibility in rats.

Rats with 60--70% deficits in brain catecholamines produced by the intracisternal injection of 6-hydroxydopamine were examined by 3 tests of seizure susceptibility. In all procedures (minimal and maximal electroshock and flurothyl convulsions) evidence for increased sensitivity to seizures was obtained. All the animals displayed normal rectal temperature at the times of seizure testing and normal blood chemistry at approximately the time of the third seizure test. These observations strengthen the widely held hypothesis that brain catecholaminergic neurons play a fundamental role in governing sensitivity to convulsions.

Animals↗
PubMedDate not supplied

Modes of action of toxic agents.

The principal modes of action of toxic agents are discussed in relation to the type of chemical bond formed between the poison and the target constituent of tissues. Alteration of enzyme activity, interference with the binding of poisonous chemicals to proteins, intercalation with nucleic acids, disturbances in electrolyte balance and the disorganization of cellular water and membrane lipids are illustrated as toxic processes involving ionic or van der Waals forces. The reactions of heavy metals with tissue nucleophiles and of exogenous nucleophiles with tissue metals are given brief attention in connection with coordinate-covalent binding. Covalent binding of poisons can arise from the incorporation of an antimetabolite into a larger molecule or reactions of electrophiles or free radicals with tissue constituents. These modes of action are illustrated by chemicals that produce necrosis, allergy or cancer.

Acylation↗