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Biomedical subjects

E W Miller

Publications and source records attributed to E W Miller.

8 recordsLinked to original sources
PubMed1985

Cellular immunolocalization of S100 protein within fixed tissue sections by monoclonal antibodies.

Monoclonal antibodies (MoAb) that cross-react with the shared epitopes of S100 protein have been prepared from mouse hybridoma cell lines and partially characterized. Nine of these MoAb were applied to sections of formaldehyde-fixed paraffin-embedded human tissues that were stained by immunohistochemical techniques. Three of these MoAb give uniformly and reproducibly positive staining in appropriate cell types when stained by avidin-biotin methods. Three of the MoAb were judged to be negative, although some MoAb gave inappropriate staining patterns. The three remaining MoAb showed either great heterogeneity in their staining patterns or intensities, or gave a lesser degree of reproducibility in a given tissue or neoplasm. One of the MoAb designated 15E2E2 that belonged to the first group of reproducibly staining antibodies was used to stain a larger number of normal human tissues and neoplasms. The staining that was observed appeared to recapitulate that which was previously described for conventional S100 protein antibodies. Monoclonal antibodies may, therefore, have a role in selected cases where standard microscopy is equivocal for a specific tissue diagnosis, or where independent verification of the diagnosis would be beneficial.

Adult↗
PubMed1983

Social stress and atherosclerosis in normocholesterolemic monkeys.

Socially stressed adult male cynomolgus monkeys (Macaca fascicularis) fed a low fat, low cholesterol diet developed more extensive coronary artery atherosclerosis than unstressed controls. Groups did not differ in serum lipids, blood pressure, serum glucose, or ponderosity. These results suggest that psychosocial factors may influence atherogenesis in the absence of elevated serum lipids. Psychosocial factors thus may help explain the presence of coronary artery disease (occasionally severe) in people with low or normal serum lipids and normal values for the other "traditional" risk factors.

Animals↗
PubMed1976

Angioplastic repair of a ruptured pulmonary artery aneurysm.

A 28-year-old woman had a ruptured solitary pulmonary arterial aneurysm which was successfully treated by pericardial patch graft. The etiology of the aneurysm could not be determined although the patient had had several episodes of blunt chest trauma in the past. Unusual aspects of this case include: location of the aneurysm in the intermediate portion of the left pulmonary artery within the major intralobar fissure, intrapleural rupture, preoperative diagnosis by pulmonary angiography, and an incidentally discovered histopathological abnormality of the aneurysm itself for which no satisfactory explanation has been found.

Adult↗
PubMed1976

Radiographic evaluation of pancreatico-jejunal shunts.

This paper describes opacification and identification of two surgically constructed pancreatico-jujunal shunts. A fibreoptic panendoscope was used with retrograde injection via the ampulla of Vater (ERCP). This procedure makes possible more accurate anatomical evaluation and so more precise clinical appraisal of both pre- and post-surgical states.

Adult↗