Biomedical subjects

E Würden

Publications and source records attributed to E Würden.

2 recordsLinked to original sources

PubMed1986

[Suppressor cell activity in patients with undifferentiated collagenoses].

Undifferentiated connective tissue syndromes (UCTS) have been considered as early stages of classical rheumatic diseases. We have studied the immunoregulatory function of T8+ cells from patients with UCTS by measuring the effects on pokeweed-mitogen-induced immunoglobulin production. Compared with normals the suppressor activity of T8+ cells was shown to be markedly diminished. These results indicate that an abnormality in generation of suppressor function may be a general feature of early stages of rheumatic diseases.

Adult↗

PubMedDate not supplied

[Suppressor T cell function in undifferentiated collagenoses].

In order to study early cellular defects in connective tissue diseases, suppressor T-cell function in undifferentiated connective tissue syndromes was determined. The capacity of T8(CD8)-positive cells to suppress pokeweed mitogen-induced IgG and IgM secretion was studied in 14 patients. Compared with normals, a reduced activity of cells to suppress the IgM response was shown, whereas the suppression of IgG secretion was not affected.

Adult↗