PubMed Health⌕ Search

Biomedical subjects

E Wainer

Publications and source records attributed to E Wainer.

12 recordsLinked to original sources
PubMed1991

Tendinous and ligamentous hyperlaxity in patients receiving longterm hemodialysis.

Chronic renal insufficiency gives rise to osteoarticular and tendinous alterations, with tendinous rupture reaching 3.6% among patients receiving hemodialysis. To evaluate potential tendinous and ligamentous alterations, 39 consecutive patients receiving longterm hemodialysis (mean dialysis time 33 months) were studied prospectively by clinicoradiological methods. Of the 39 cases, atlantoaxial subluxation was found in 3 (7.7%). Tendinous or ligamentous hyperlaxity was present in 29 (74%) with patellar tendon elongation in 19 (49%), articular hypermobility in 20 (51%) and both in 10. Differences were significant (p less than 0.05) in patients with articular hypermobility with over 36 months' dialysis, and even more so (p less than 0.01) in those with over 48 months. Atlantoaxial subluxation was more frequent after 48 months' dialysis. Therefore, patients receiving longterm hemodialysis are prone to present tendinous or ligamentous hyperlaxity with atlantoaxial subluxation as well.

Adult↗
PubMed1982

Effects of pindolol on renal function II. Effects on intravenous and prolonged oral dosing.

Effects of intravenous and long-term oral dosing with pindolol on renal function were examined in eight hypertensive patients with reduced renal function. (Inulin clearance ranged from 40.5 to 84.5 ml/min/1.73 m2.) Intravenous pindolol resulted in decreased mean heart rate (74.3 to 67 bpm) and decreased mean inulin clearance (66 to 60.5 ml/min/1.73 m2.) Blood pressure and renal plasma flow did not change significantly. Long-term oral pindolol depressed blood pressure and heart rate, but mean inulin clearance was unchanged and renal blood flow and plasma volume increased. A second intravenous pindolol dose, given while the patients were receiving oral doses, resulted in nonsignificant decreases in glomerular filtration rate and renal plasma flow, but no change in blood pressure and heart rate. We conclude that prolonged pindolol dosing in patients with reduced renal function had no effect on renal function. When the drug was given intravenously there were small decreases in glomerular filtration rate and renal plasma flow.

Administration, Oral↗
PubMed1982

Renal function during acute and long term pindolol treatment in hypertensive patients with normal and decreased glomerular filtration.

1 In an acute study in hypertensive patients with normal and decreased renal function the i.v. administration of pindolol (0.1 mg/kg) caused a decrease in inulin clearance and a concomitant but not significant decrease in PAH clearance with a constant filtration fraction. 2 The long-term administration of pindolol (5--20 mg/day) to hypertensive patients with normal renal function was not associated with changes in renal function but in patients with a decreased renal function, pindolol caused an increase in PAH clearance but no change in inulin clearance.

Administration, Oral↗
PubMed1982

Is secondary hyperparathyroidism an important etiologic factor in the anemia of chronic renal failure?

Twenty patients with chronic renal failure being treated with hemodialysis were investigated in an attempt to ascertain whether hyperparathyroidism is an important etiologic factor in these patients' anemia. The patients were divided into two groups, one with hemoglobin of greater than 8 g/dl and the other with hemoglobin of less than 8 g/dl. These groups differed in blood transfusion requirements and in serum iron saturation. There was no difference between their levels of serum calcium, serum phosphate, serum alkaline phosphatase or serum parathyroid hormone. On bone biopsy endosteal fibrosis with bone marrow involvement was found in 2 of the 11 patients with high hemoglobin and in 5 of the 9 patients with low hemoglobin. Endosteal fibrosis with bone marrow involvement may thus be an important factor in the pathogenesis of anemia, and its presence or absence in association with hyperparathyroidism may explain the controversial observations reported by other investigators.

Adult↗
PubMed1981

Clearance of Tc-99m DTPA in hemodialysis and peritoneal dialysis: concise communication.

The clearance of Tc-99m DTPA was studied in 14 patients undergoing hemodialysis (HD) or peritoneal dialysis (PD). Mean Tc-99m DTPA clearance during HD was 37.8% +/- 10.1 of creatinine clearance. Mean Tc-99m DTPA clearance in PD was 65.1% +/- 10.3 of creatinine clearance. Tc-99m DTPA, with a larger molecular weight than that of creatinine, is cleared relatively better during PD than during HD. Thus Tc-99m DTPA may be used in the assessment of the effectiveness of different dialytic treatments for substances of similar molecular weight. In addition, our study shows that clearance of DTPA both in HD and PD is sufficiently high to allow the removal of this chelating agent in patients with renal failure.

Blood Flow Velocity↗
PubMed1981

The effects of proxazole on renal function in chronic renal failure.

3-alpha-Phenyl-propyl-5-beta-diethylaminoethyl-1,2,3-oxadiazole (proxazole), a spasmolytic papaverine-like agent, was i.v. administered to 13 patients with chronic renal failure (mean creatinine clearance 46.4 ml/min/1.73 m2), but did not improve renal plasma flow (p-aminohippurate clearance) or glomerular filtration rate (inulin clearance), nor did this agent prevent or modify nor-adrenaline induced renal ischemia. The oral administration of 400 mg proxazole (5.2--6.5 mg/kg/day) for a period of at least 90 days did not improve renal function in 11 patients with chronic renal failure. It is concluded that both i.v. and p.o. administration of proxazole in the dosages used is ineffective in improving renal function in patients with chronic renal failure.

Administration, Oral↗
PubMed1981

Fulminant spontaneous acute bacterial peritonitis in maintenance hemodialysis.

Two patients on maintenance hemodialysis therapy developed fulminant spontaneous acute bacterial peritonitis (S.A.B.P.). Both had positive blood cultures and died within a few hours despite intensive antibiotic and supportive therapy. No intra-abdominal source of the peritonitis was found in either case. Though septicemia is an important cause of death in the hemodialyzed patient, this form of presentation (S.A.B.P.) has not been previously reported.

Adult↗
PubMed1980

Effects of pindolol on renal function.

Because beta blockers have been shown to reduce glomerular filtration rate (GFR), the renal effect of intravenous and prolonged oral administration of pindolol was examined in 10 patients with essential hypertension. Intravenous pindolol decreased inulin clearance from 99 to 94 ml/min/1.73 m2 (p < 0.005), and pulse rate from 75 to 69/min (p < 0.005). Blood pressure and filtration fraction were not changed. Oral pindolol (10 to 20 mg/day) for a mean of 6 mo resulted in a decrease in mean blood pressure from 124 to 111 mm Hg (p < 0.001), in mean pulse rate from 76 to 69/min (p < 0.005), and in mean plasma renin activity (PRA) from 0.9 to 0.29 ng/ml/hr (p < 0.05). Inulin clearance and filtration fraction did not change. At the end of oral therapy, intravenous pindolol induced a greater reduction in inulin clearance than in the first study. These observations indicate that intravenous pindolol induces a decrease in GFR probably secondary to hemodynamic effects. On the other hand, prolonged oral pindolol has no effect on GFR despite decreases in blood pressure, pulse rate, and PRA.

Adult↗