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Biomedical subjects

E Welinder

Publications and source records attributed to E Welinder.

7 recordsLinked to original sources
PubMed1985

Combined effects of DL-alpha-aminoadipic acid with sodium iodate, ethyl alcohol, or light stimulation on the ERG c-wave and on the standing potential of albino rabbit eyes.

Albino rabbits were treated with intravitreal injections of DL-alpha-aminoadipic acid (alpha-AAA) into one eye (0.1 ml of a 0.15 M solution) and 0.1 ml of saline into the contralateral eye. Thirteen to fourteen hours later the DC electroretinogram (ERG) and/or the standing potential (SP) were recorded. (1) In eight of nine animals the c-wave amplitude of alpha-AAA injected eyes was increased compared with that of control eyes. Following intravenous injection of Sodium Iodate (40 mg/kg in 2% solution) the c-waves of both eyes were rapidly replaced by negative potentials. In 8 of 9 animals the amplitude reduction was more marked in alpha-AAA-treated eyes than in control eyes, but the final amplitude was higher in the former than in the latter. The SP was reduced with difference in curve form but not significantly in amplitude between the eyes. (2) In nine other rabbits iv.-injected ethyl alcohol (0.4 g/kg in 20% solution) provoked a transient increase of SP level and c-wave amplitude in control eyes and smaller but similar changes in alpha-AAA injected eyes. (3) In another five animals the SP was recorded following a step from darkness to continuous light stimulation. The light peak was less pronounced in alpha-AAA treated eyes than in control eyes.

2-Aminoadipic Acid↗
PubMed1982

Early effects of sodium iodate on the slow off-effects, particularly the h-wave, and on the c-wave of the DC recorded electroretinogram in rabbit.

The early effects of intravenously administered sodium iodate (NaIO3) on the slow, negative 'off-effect', the h-wave, and on the slow, positive 'on-effect', the c-wave, of the DC recorded electroretinogram were studied in 8 rabbits. Both the h- and c-waves disappeared gradually after NaIO3 administration and were replaced by potentials of opposite polarity. These results strongly support the assumption that the h-wave originates in the pigment epithelium and represents the reversal of events underlying the c-wave. The slow, positive 'off-effect', the g-wave, elicited by 'dark flashes' was seen to pass into the potential replacing the h-wave after NaIO3 treatment.

Animals↗
PubMed1982

Effects of intravitreally injected DL-alpha-aminoadipic acid on the c-wave of the D.C.-recorded electroretinogram in albino rabbits.

The D.C. electroretinogram of four adult albino rabbits was studied 13.5 to 15 hr after injection of 0.1 ml of 0.15M DL-alpha-aminoadipic acid (alpha-AAA) into the vitreous body of one eye. The other eye was similarly injected with saline and served as control. In the alpha-AAA--treated eye the b-wave was markedly reduced or absent and the a- and c-waves increased compared with the control eye. Sincs alpha-AAA damages the Müller cells, the results support the view that these cells are related to the generation of the b-wave and to the negative slow PIII-potential, which modifies the positive pigment epithelial component of the c-wave.

2-Aminoadipic Acid↗
PubMed1981

Early effects of sodium iodate on the directly recorded standing potential of the eye and on the c-wave of the DC registered electroretinogram in albino rabbits.

The early effects of intravenously administered sodium iodate (NaIO3) on the directly recorded standing potential (SP) of the eye and on the c- and b-waves of the DC registered ERG were studied in 8 anaesthetized albino rabbits. In 5 of 6 animals obtaining 40 mg NaIO3/kg bwt. the SP decreased immediately following the injection, and had attained a level 3.5 - 4 mV below the original one after 1 h. The c-wave declined rapidly and 6 min after the injection it was replaced by a large cornea-negative potential. The b-wave was relatively unchanged except in one animal. In 2 rabbits treated with 30 mg NaIO3/kg btw. and in the 6th animal obtaining 40 mg NaIO3/kg bwt. an SP increase instead of a decrease was seen, and the c-wave was more slowly (about 22 min after the injection) replaced by the cornea-negative potential. The b-wave was somewhat increases. These results demonstrate the dose-related and inter-individual variability in the SP reaction to NaIO3 and are in good agreement with the well-known ultrastructural pigment epithelial injury and c-wave changes produced by this substance.

Animals↗