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Biomedical subjects

E Wenger

Publications and source records attributed to E Wenger.

33 records · Page 2Linked to original sources
PubMed1989

Collagen dysplasia in idiopathic carpal tunnel syndrome.

Surgical biopsies of dissected transverse carpal ligaments of patients with idiopathic carpal tunnel syndrome were examined with an electron microscope revealing collagen fibrils with extremely varying diameters. Morphometric analysis was performed on electron micrographs exhibiting fibrils with a small diameter comparable to that in control tissue as well as fibrils with a far larger diameter than could be observed in control tissue. Morphometric parameters were evaluated in order to analyse the relation between the number of and the area covered by collagen fibrils in the electron micrographs. In control tissue the numerical density per image area was twice the numerical density in carpal tunnel syndrome. However, the area fraction of the electron micrographs occupied by collagen fibrils in carpal tunnel syndrome and controls were equal.

Biopsy↗
PubMed1989

The controversy about a sexual dimorphism of the human corpus callosum.

A sexual dimorphism of the splenium corporis callosi in man was reported in 1982. The authors described the posterior part of the female corpus callosum to be larger and more bulbous than its male counterpart. From the lateralization research, it has previously been stated that the female brain is less well lateralized for visuospatial functions than the male. The authors postulated that a larger splenium implies a larger number of fibers and that the number of interhemispheric fibers correlates inversely with lateralization of function. However, their sample was very small and not adequately matched for sex. Therefore, we reinvestigated this question. A standardized computer assisted program will be presented. With this program the "classical" parameters have been evaluated and the "rotatory diameter measurement" was performed. No differences between the sexes were seen either for the splenium corporis callosi or for the other parts of the corpus callosum.

Adult↗
PubMed1987

Morphometric analysis of collagen fibrils in idiopathic carpal tunnel syndrome: Part 2.

Morphometric parameters were evaluated in order to analyze the relation between number and covered area of collagen fibrils in normal and carpal tunnel syndrome tissue. This analysis revealed that in normal tissue twice as many collagen fibrils as in pathological tissue occupy an equal area. Taking these facts into account, some hypotheses are advanced.

Biopsy↗
PubMed1978

A histochemical method for gross demonstration of motor end plates.

The thiocholine-ferricyanide method of Karnovsky and Roots for histochemical demonstration of cholinesterases has been applied to whole fetal and neonatal mice and chicks for the visualization of motor end plate patterns in superficial muscles or deeper muscles exposed by dissection.

Animals↗
PubMedDate not supplied

A method for the quantification of the size of liver metastases.

A method for the quantification of the size of liver metastases based on stereologic principles is presented. This evaluation procedure was applied retrospectively to routine computerized tomography (CT) scans of the liver and allowed reliable estimation of the volume of liver metastases. Furthermore, the data were used to create three-dimensional (3D) representations of the examined organ by computer reconstruction.

Adult↗
PubMedDate not supplied

[Spondylodiscitis as a dominant early symptom of juvenile ankylosing spondylitis].

A 12-year-old female (HLA-B27 negative) presented with unilateral low back pain and sterno-clavicular arthritis. Six months after onset the clinical and radiological findings determined spondylodiscitis L1/2. On the basis of the clinical findings (oligoarthritis, symptomatic sacroilitis, spondylodiscitis), juvenile ankylosing spondylitis was suspected. The diagnosis was corroborated 18 months after the first occurrence of symptoms by the appearance of typical changes in the sacroiliac joint that are indicative of juvenile ankylosing spondylitis. Because of persisting antibodies against Borrelia burgdorferi, the possibility of B. burgdorferi-induced reactive arthritis with involvement of the axial division of the skeletal system was considered. After 3.5 years of observation the condition showed a benign course with radiologically observable consolidation of the spondylodiscitis. To our knowledge, this is the second case described of juvenile ankylosing spondylitis with spondylodiscitis as a dominating feature.

Arthrography↗
PubMedDate not supplied

Morphometric analysis of the corpus callosum using MR: correlation of measurements with aging in healthy individuals.

PURPOSE: To analyze changes of the human corpus callosum and MR midsagittal brain structures during normal aging. METHODS: A morphometric evaluation strategy for quantification of these brain structures on MR scans was developed. This computerized measuring program did allow the acquisition of more than 100 one- and two-dimensional parameters. RESULTS: During normal aging, the anterior parts of the corpus callosum (genu and anterior parts of the trunk) were significantly decreased, suggesting alterations of frontal and temporal interhemispheric fiber systems. Further changes were seen in callosal thickness and callosal width of the anterior parts of the corpus callosum. The profile area of the telencephalon was significantly reduced during normal aging. The size of the mesencephalon showed age-specific changes. CONCLUSIONS: The proposed computer program proved to be a powerful and reliable tool to get objective and reproducible quantitative data of corpus callosum and midsagittal brain structures. Specific age changes were found in the corpus callosum, indicating alteration of the frontotemporal interhemispheric fiber systems.

Adult↗