Heat-sensitive mycoplasma antigens.
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Animals↗
Biomedical subjects
E Wheeler
Publications and source records attributed to E Wheeler.
Aluminum inhibits neurofilament assembly, cytoskeletal incorporation, and axonal transport. Dynamic nature of aluminum-induced perikaryal neurofilament accumulations as revealed by subunit turnover.
The mechanism by which aluminum induces formation of perikaryal neurofilament (NF) inclusions remains unclear. Aluminum treatment inhibits: 1. The incorporation of newly synthesized NF subunits into Triton-insoluble cytoskeleton of axonal neurites; 2. Their degradation and dephosphorylation; 3. Their translocation into axonal neurites. It also fosters the accumulation of phosphorylated NFs within perikarya. In the present study, we addressed the relationship among these effects. Aluminum reduced the assembly of newly synthesized NF subunits into NFs. During examination of those subunits that did assemble in the presence of aluminum, it was revealed that aluminum also interfered with transport of newly assembled NFs into axonal neurites. Similarly, a delay in axonal transport of microinjected biotinylated NF-H was observed in aluminum-treated cells. Aluminum also inhibited the incorporation of newly synthesized and microinjected subunits into the Triton-insoluble cytoskeleton within both perikarya and neurites. Once incorporated into Triton-insoluble cytoskeletons, however, biotinylated subunits were retained within perikarya of aluminum-treated cells to a greater extent than within untreated cells. Notably, these subunits were depleted in the presence and absence of aluminum within 48 h, despite the persistence of the aluminum-induced perikaryal accumulation itself, suggesting that individual NF subunits undergo turnover even within aluminum-induced perikaryal accumulations. These findings demonstrate that aluminum interferes with multiple aspects of neurofilament dynamics and furthermore leaves open the possibility that aluminum-induced perikaryal NF whorls may not represent permanent structures, but rather may require continued recruitment of cytoskeletal constituents.
Aluminum↗
Trends in the growth of ethnic Chinese children living in London.
Height, weight and triceps skinfold thickness of children aged 5 years and under were measured in a semi-longitudinal study of 50 Chinese families in London. Heights and weights of their mothers were also measured once. The children were taller and heavier than Chinese children in Hong Kong, but height-forage, when expressed as a percentage of the UK median value, declined after two years of age. The pattern of growth of triceps skinfold did not conform to the UK standards.
Asian People↗
Influence of a mindfulness meditation-based stress reduction intervention on rates of skin clearing in patients with moderate to severe psoriasis undergoing phototherapy (UVB) and photochemotherapy (PUVA).
OBJECTIVE: This study tests the hypothesis that stress reduction methods based on mindfulness meditation can positively influence the rate at which psoriasis clears in patients undergoing phototherapy or photochemotherapy treatment. METHODS: Thirty-seven patients with psoriasis about to undergo ultraviolet phototherapy (UVB) or photochemotherapy (PUVA) were randomly assigned to one of two conditions: a mindfulness meditation-based stress reduction intervention guided by audiotaped instructions during light treatments, or a control condition consisting of the light treatments alone with no taped instructions. Psoriasis status was assessed in three ways: direct inspection by unblinded clinic nurses; direct inspection by physicians blinded to the patient's study condition (tape or no-tape); and blinded physician evaluation of photographs of psoriasis lesions. Four sequential indicators of skin status were monitored during the study: a First Response Point, a Turning Point, a Halfway Point, and a Clearing Point. RESULTS: Cox-proportional hazards regression analysis showed that subjects in the tape groups reached the Halfway Point (p = .013) and the Clearing Point (p = .033) significantly more rapidly than those in the no-tape condition, for both UVB and PUVA treatments. CONCLUSIONS: A brief mindfulness meditation-based stress reduction intervention delivered by audiotape during ultraviolet light therapy can increase the rate of resolution of psoriatic lesions in patients with psoriasis.
Adult↗
Analysis of the weights of infants of Bangladeshi origin attending two clinics in Tower Hamlets.
The weights of 220 infants of Bangladeshi origin attending two clinics in the London Borough of Tower Hamlets were analysed at birth, 6 months and 18 months of age. The weights were compared first with the Tanner-Whitehouse standards derived from English children and then with Indian data from the infants of well-to-do families. The mean weights of the infants of Bangladeshi origin were below the British Tanner-Whitehouse 50th centiles, approximating to the 25th centile values. As the means were similar to those reported from well-nourished Indian infants, it is unlikely that the Bangladeshi infants were undernourished. The reported weights of well-nourished Indian infants appeared to be a more appropriate reference for the infants of Bangladeshi origin than the Tanner-Whitehouse values. However the Tanner-Whitehouse charts can be used, but with their 25th, 10th and 3rd centile lines being taken to read 50th, 25th and 10th centiles, respectively. Significantly more boy than girl infants were brought to one of the clinics.
Bangladesh↗
Implementing an automated care planning system in a nursing curriculum.
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Curriculum↗