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Biomedical subjects

E Winter

Publications and source records attributed to E Winter.

82 records · Page 5Linked to original sources
PubMed1976

[Drug abuse and dependence of the amphetamine type with special regard to Amphetaminil (Aponeuron(R))].

In 1974 amphetaminil was included in the class of addictives or habit-forming drugs, although prescription of the drug is not requiring adherence to strict requirements. Whereas reports of abuse of, and addiction to, amphetaminil have been published in foreign countries since 1967, it was not considered a habit-forming drug in the G.D.R. Observations made by the author and his associates show that this may not be true; abuse of, and addiction to, this particular drug are possible in this country, too. The concern of this paper is to call the reader's attention to possible addiction to amphetamine type drugs. Prescription of amphetamines should always be with caution in order to prevent abuse. It is recommended that careful consideration be given to the question of limiting the amount of amphetaminil to be prescribed.

Acetonitriles↗
PubMedDate not supplied

The risks of reuse: legal implications for hospitals of reusing single-use medical devices.

There is no doubt that the practice of reuse in hospitals is a reaction to the budgetary constraints under which hospitals are operating. However, the costs of appropriately monitoring and sterilizing reused equipment as well as the significant risk of patient harm and potential liability raise the unavoidable question of whether this practice is an advisable one. These costs and risk should be carefully examined before a decision about whether to reuse single-use devices is made.

Canada↗
PubMedDate not supplied

The c-K-ras gene and human cancer (review).

A significant number of human tumors from diverse histological origins contain c-K-ras oncogenes which have been activated by somatic point mutations resulting in single amino acids substitutions in the encoded p21 ras protein. In addition to these qualitative changes, other genetic alterations leading to increased expression of the c-K-ras gene, especially its mutated form, appear to be important in the activation of its oncogenic potential. These findings support the hypothesis that c-K-ras oncogenes are contributing in a dominant but dose dependent manner to the multistage process of human tumorigenesis. Activated c-K-ras oncogenes have been detected in human tumors at different stages of progression, including premalignant neoplasms. These studies provide evidence for the involvement of somatic mutational activation of this ras gene in the early stages of tumor development in some types of human cancer. We discuss here the structural and functional features of the human c-K-ras gene and the involvement of its activated form in human cancer.

Amino Acid Sequence↗