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Biomedical subjects

E Woltering

Publications and source records attributed to E Woltering.

6 recordsLinked to original sources
PubMed1986

Polar solvents in the chemoprevention of dimethylbenzanthracene-induced rat mammary cancer.

Differentiating agents have been used experimentally and clinically as an adjuvant in the treatment of cancer, but their role in chemoprevention is limited. We used 5% dimethylsulfoxide (DMSO), 1% and 4% methylsulfonylmethane (MSM), 0.3% N-methylformamide (NMF), and retinol acetate (RA) in the chemoprevention of rat mammary breast cancer. One hundred fifty 42-day-old Sprague-Dawley rats were randomized into six groups (control, RA, DMSO, 1% MSM, NMF, and 4% MSM) and received chemopreventive agents along with standard rat chow ad libitum. Eight days later, 15 mg of 7,12-dimethylbenzanthracene was given by oral gastric intubation. The animals were examined weekly for tumor incidence and size (biplanar analysis). Animals were followed up for 240 to 300 days. Tumor incidence was not statistically affected. Time to appearance (latency period) of both tumors and cancers were prolonged by NMF, DMSO, and 4% MSM. Doubling times of all cancers produced were prolonged by DMSO and RA. No group exhibited toxic reactions or significant weight loss. Polar solvents and differentiating agents, specifically NMF, DMSO, and 4% MSM, were effective in the chemoprevention of dimethylbenzanthracene-induced mammary cancers.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1985

A simple method for identifying and testing the recurrent laryngeal nerve.

Simultaneous stimulation of the recurrent laryngeal nerve and palpation of an impulse in the homolateral cricothyroid area was performed upon 20 patients. Electrical stimulation of the recurrent laryngeal nerve with currents of 2 milliamperes caused no postoperative deficits in any of the patients studied. This is a simple and reproducible method to help identify the RLN and to confirm that the recurrent nerve is intact and viable at the completion of a surgical procedure. The technique is simpler than checking cord motion at the conclusion of surgical procedures upon the thyroid or parathyroid glands. Due to the variability of the response in some of the patients, we believe that the procedure should be tried on more patients before it is recommended as a conclusive test.

Electric Stimulation↗
PubMed1984

Pancreatitis induced by intravenous infusion of a fat emulsion in an alcoholic patient.

We report an alcoholic patient with acute relapsing pancreatitis in whom the intravenous infusion of a fat emulsion precipitated a bout of acute pancreatitis. The various relationships between pancreatitis, alcoholism, and hyperlipemia are not clear, and guidelines for the use of intravenous fat emulsions in patients with pancreatitis should take into account their complex interrelationship.

Acute Disease↗
PubMed1984

Management of penetrating hepatic injury. A review of 102 consecutive patients.

The records of 102 consecutively treated patients with penetrating hepatic injuries from 1972 through 1982 were reviewed. Fifty-five patients (54%) sustained gunshot wounds and 47 (46%) sustained knife wounds. The mean age was 29 years (range 3-71); 83 per cent were men. Hypovolemic shock was present in 39 per cent of all the patients, and 74 patients (73%) required perioperative transfusions. Major associated injuries were present in 65 patients (64%) with 30 patients having two or more other injuries. All patients received preoperative and postoperative antibiotics and 88 per cent were treated with intraabdominal drains. Fifteen patients were managed with a tamponade technique using multiple Penrose drains within the injury tract. Six patients (5.9%) required hepatic resection. Major vascular injuries were present in ten cases, and seven of these patients survived. Hospital stay ranged from 4 to 60 days with a mean of 14 days. Postoperative complications occurred in 42 per cent of the patients with over one-third of the complications being pulmonary related. Mortality was 2.9 per cent and all three deaths were secondary to bleeding from severe liver and associated vascular injuries. The low incidence of hepatic resection and mortality in this series of patients is attributed to the conservative management of liver injuries, adequate drainage, the use of a tamponade technique with multiple Penrose drains for through-and-through liver injuries and the expeditious repair of the vascular injuries. This paper includes a detailed description of the tamponade technique.

Adolescent↗
PubMed1980

Simultaneous measurement of tumor cytosol and peripheral serum levels of human chorionic gonadotropin and alphafetoprotein in testicular cancer.

We measured tumor cytosol and peripheral serum levels of human chorionic gonadotropin (HCG) and alphafetoprotein (AFP) simultaneously in 40 patients with nonseminomatous testicular cancer. Serum AFP levels were normal in 13 of 40 patients and were elevated in 7 of 13 (54%) tumor cytosols from these patients. Serum HCG levels were normal in 16 of 40 patients and were elevated in 13 of 16 (81%) tumor cytosols from these patients. Correlation of simultaneous serum and tumor cytosol levels of HCG and AFP indicates that tumor cytosols are more likely to have elevated levels of HCG and/or AFP than are sera in patients with testicular tumors.

Chorionic Gonadotropin↗