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Biomedical subjects

E Wylegała

Publications and source records attributed to E Wylegała.

At least 19 recordsLinked to original sources
PubMed2006

Corneal grafting and aggressive medication for corneal defects in graft-versus-host disease following bone marrow transplantation.

PURPOSE: To evaluate the clinical outcomes of corneal grafting for severe dry eye complications in bone marrow transplant recipients. METHODS: Eleven eyes of nine patients with severe corneal complications of chronic graft-versus-host disease were treated from 2000 to 2005. The subjects underwent penetrating keratoplasty (n=9 eyes; seven for perforation and two for leucoma) or deep anterior lamellar keratoplasty (n=2 eyes) for deep postinflammatory stromal scarring without endothelial abnormalities. Patients were observed for graft survival, visual acuity, and postoperative complications. RESULTS: During the follow-up period (mean=21.6 months), nine grafts (82%) remained clear or almost entirely clear and gained more than two logarithmic units of best-corrected visual acuity. Two regrafts were necessary as the primary grafts became cloudy after 9 and 11 months. Persistent epithelial defects occurred in seven eyes (64%), cataract in six (55%), ocular hypertension in five (45%), corneal calcareous degeneration in two (18%), loss of clarity in two (18%), and sterile ulceration in one (9%). CONCLUSION: Corneal grafting was effective for restoring corneal clarity and improving visual function in this series of patients. Although the complication ratio was high and some patients required regrafting, there was a clinical improvement in the majority of patients.

Acute Disease↗
PubMed2002

Electron spin resonance investigations of human retinal pigment epithelium melanosomes from young and old donors.

Electron spin resonance (ESR) examinations of human retinal pigment epithelium melanosomes isolated from eyes of young and old donors were carried out. The examined ESR signal was a single line, which is characteristic for free radicals of eumelanin o-semiquinones. The content of free radicals related to melanosomes dry weight for samples from older donors (ages over 45 years) were higher than for sample from younger donors (between 14 and 22 years). Simultaneously, the content of free radicals calculated for one melanosome is constant and does not depend on age. The homogeneous broadening of the recorded ESR lines shows that there are no isolated spin packets in all investigated melanin samples. Slow spin-lattice (T1 approximately 10(-5) s) and fast spin-spin (T2 approximately 10(-8) s) relaxation processes occur in these samples. Saturation of the ESR lines at low microwave power was measured. High concentration of free radicals in melanosome samples was responsible for the fast spin-spin relaxation process.

Adolescent↗
PubMed2000

[Surgical correction of astigmatism after wedge resection keratoplasty].

PURPOSE: To analyse the results of astigmatism correction after keratoplasty using wedge resection technique. MATERIAL AND METHODS: Eleven patients underwent a wedge resection for postkeratoplasty astigmatism. The average postoperative astigmatism was 13.9 diopters (range 11.0 to 17.0 D). Among the patients there were 5 women and 6 men, aged 25 to 70 years. All of the grafts were in static phase, after suture removal. The indications for keratoplasty were: keratoconus--8, pseudophakic and aphakic corneal edema--3. The follow-up period after wedge resection was 6 to 24 months. The astigmatism was evaluated by videokeratometer (ORC Masterviue Ultra). RESULTS: Postoperatively, the average astigmatism was 7.25 D by 6 months, 8.1 D by 12 months, 8.45 D by 24 months. The visual acuity corrected with spectacles was 0.2 to 1.0. 8 patients (72.7%) gained better visual acuity. Complications included: 1) growing vessels through the wound, 2) delay of epithelization. CONCLUSION: Wedge resection is an effective technique for managing postkeratoplasty high astigmatism.

Adult↗
PubMed1999

[Trans-sclerally fixated PC-IOLs: six year of investigations].

PURPOSE: To present the results of PC IOLs transscleral fixation to the ciliary sulcus in six years follow-up. MATERIAL AND METHODS: 152 eyes in 3 groups: 15 eyes with primary fixations of PC IOLs, 92 eyes with secondary fixations of PC IOLs and 45 eyes with secondary fixations of PC IOLs combined with penetrating keratoplasty. RESULTS: Postoperative corrected visual acuity was 0.5 or better in 32.2% of cases, the most common complications in our material was CME (9.9%), lens tilt (4.6%) and increase of IOP (3.95%). CONCLUSION: Transscleral fixation of PC IOLs offers good visual outcome with relatively low rate of complications and is recommended in cases with inadequate posterior capsule support.

Ciliary Body↗
PubMed1999

[Glaucoma after penetrating keratoplasty in the material of the ocular department of the Mountain Hospital in Sosnowiec].

PURPOSE: To evaluate the necessity of antiglaucoma therapy in patients after penetrating keratoplasty (PK). MATERIAL AND METHODS: An analysis of 537 penetrating keratoplasties performed in our department was undertaken. Incidence of glaucoma after penetrating keratoplasty procedure, necessity of pharmacological antiglaucoma treatment as well as the kind of surgical procedure and its influence on the graft transparency were estimated. RESULTS: The incidence of post keratoplasty glaucoma was 11.2% (60/537). 42 patients required pharmacological treatment (42/60) and the remaining 18 required surgery. 12 trabeculectomies, 6 drainage devices procedures and 1 cyclokrytherapy were performed and stabilization of intraocular pressure was obtained. 14 of the grafts treated surgically lost their transparency. CONCLUSIONS: Multiple surgical treatment of post-penetrating keratoplasty glaucoma, despite the stabilisation of the intraocular pressure, may lead to loss of graft transparency in most cases.

Evaluation Studies as Topic↗
PubMed1999

[Keratectomy for a malignant melanoma of the cornea].

PURPOSE: To present the possibility of malignant melanoma treatment of the cornea using keratectomy. MATERIAL AND METHODS: A 59-year old woman with a primary malignant melanoma of the cornea. Visual acuity before surgery 0.2. Malignant melanoma was removed using keratectomy. Follow-up 18 months. RESULTS: Satisfactory cosmetic result and visual acuity 1.0 was obtained. In 18 months follow-up no local or general symptoms of tumor recurrence are observed. CONCLUSION: Keratectomy should be considered as an alternative treatment for primary malignant melanoma of the cornea.

Cornea↗
PubMed1999

[Valve implants of glaucoma pressure regulator for refractory glaucoma: own experience].

PURPOSE: To present our experiences in valve implantation for refractory glaucoma. MATERIAL AND METHODS: From October 1993 to December 1996 implantations of Glaucoma Pressure Regulator Optimed were performed in 7 eyes of 7 patients. There were 4 men and 3 women aged from 32 to 65 years. There were 3 eyes with neovascular glaucoma due to diabetes mellitus, 2 eyes with posttraumatic glaucoma, including 1 case after keratoplasty, 1 eye with postkeratoplasty glaucoma and 1 eye with aphakic glaucoma. Preoperative IOPs ranged from 33 to 61 mm Hg (mean 37.6 +/- 7.2 mm Hg). RESULTS: Success was considered an IOP of less than 22 mm Hg without medication (complete success) or with medication (qualified success) without additional filtering surgery. Postoperative success was obtained in 4 out of 7 eyes after follow-up period of 37.4 +/- 17.08 months (range 16-39 months). Early complications were hyphema (1 patient, 14.3%), blockage of intracameral portion of the tube (1 patient, 14.3%), hypertony (1 patient, 14.3%). Late complications were: external conjunctival bleb failure (2 patients, 28.6%), blockage of intracameral portion of tube by fibrovascular tissue (1 patient, 14.3%). CONCLUSION: Our experiences confirm that the valve implant is still today an alternative surgical procedure for controlling IOP in eyes with refractory glaucoma that have visual potential.

Adult↗
PubMed1996

[Evaluation of the usefulness of the laryngeal mask for general anesthesia in eye microsurgery--preliminary results].

PURPOSE: This prospective study was designed to compare intraocular pressure changes and haemodynamic response to insertion of either a laryngeal mask or an orotracheal tube during general anaesthesia for cataract surgery. MATERIAL AND METHODS: The effect of techniques (tracheal tube-TT, laryngeal mask airway-LMA) securing a clear upper airway on the heart rate changes (HR), arterial pressure (SAP, DAP), oxygen saturation (SpO2), end-tidal carbon-dioxide pressure (Et-CO2), intraocular pressure (IOP) and the incidence of coughing, stridor and sore throat was analysed in 60 patients undergoing cataract surgery during general anaesthesia. RESULTS: The mean values for HR, SAP, DAP and IOP measured before and after induction of anaesthesia were not different in both groups. After securing a clear airway, mean HR increased in TT group to 95.5/min and decreased to 75.7/min in LMA group. SAP increased in TT group to 131 mmHg, DAP to 82.6 mmHg, whilst in LMA group both values decreased to 98.6 mmHG and 66.3 mmHg, respectively. The significant difference in IOP values was observed after intubation or using laryngeal mask. In TT group, intraocular pressure increased to 15 mmHg in healthy eye and to 13.6 mmHg in ill eye whilst there was a decrease in LMA group to 5.5 and 7.43 mmHg, respectively. Furthermore, a greater incidence of such complications as coughing, stridor and sore throat in TT group was observed. CONCLUSION: The results show that using LMA in microsurgery during general anaesthesia is more advantageous and safer for patients in comparison with tracheal intubation.

Adult↗
PubMed1992

[Late results of stomatologic and ophthalmologic treatment of injuries involving the central part of the face].

The authors present an analysis of the results of treatment of patients with injury of the central fragment of the face, who have been hospitalized in the 2nd Department of the Maxillofacial surgery in Silesian Academy of Medicine. In the period 1980-1987 there were 447 patients with an injury of the central fragment of the face. Among this group 60 (13.4 p.c.) patients showed disturbances of the visual system. The most frequent causes of the injury were: assault (61.5 p.c.), traffic accidents (20.1 p.c.), occupational injuries (8.8 p.c.). Deformation of the face was the most frequent pathology observed in the course of a control stomatological check-up (32.0 p.c.). The most important ocular pathology were the posttraumatic atrophy of the eye (3.3 p.c.) and optic atrophy. Palpebral scars (33 p.c.) and diplopia (7.6 p.c.) were the most frequent ocular signs.

Eye Diseases↗
PubMed1990

[Free fatty acid levels in the blood serum and aqueous humor of patients with cataract].

The authors present the results of determination of the level of free fatty acids in the serum and aqueous in patients with a senile cataract (23 persons), with cataract and glaucoma (9 persons), complicated post-uveitis cataract (10 persons) and diabetic cataract (10 persons). The level of the free fatty acids in senile cataract was significantly lower in the aqueous in comparison with the serum. Their content in senile cataract was significantly lower in comparison with cataract and glaucoma and with complicated cataract.

Aged↗
PubMed1990

[Extracapsular extraction of hard cataract with simultaneous implantation of intraocular lens and anti-glaucoma operation].

The authors present 7 cases of extracapsular hard cataract extraction with implantation of posterior chamber lens or an intracapsular disc-shaped lens. Because of existing indications they performed simultaneously an anti-glaucoma operation. In all the cases the postoperative IOP persisted in normal limits without any necessity of application of a pharmacological treatment.

Aged↗
PubMed1990

[Comparison of the effectiveness of bupivacaine with xylocaine and xylocaine alone used for akinesia and retrobulbar anesthesia in cataract surgery].

The paper presents a comparison of the efficacy of Bupivacaine with Xylocaine and Xylocaine alone used for retrobulbar injection and akinesia in cataract surgery. Two groups comprising 50 patients each were subjected to evaluation. The results obtained encourage to put into practice the mixture of Bupivacaine with Xylocaine for local anaesthesia in cataract operations.

Anesthesia, Local↗
PubMedDate not supplied

[Penetrating keratoplasty in post-burn corneal leukoma in personal material].

The authors present the surgical technique and the results of treatment of 12 patients with corneal leukoma caused by scalding. In all the cases they performed a perforating keratoplasty. Two years after operation among 7 grafts 5 were transparent. Perforating grafts in leukoma caused by a chemical burn have poor prognosis in contrary to thermic burns.

Adult↗
PubMedDate not supplied

[Keratoplasty with simultaneous cataract extraction and implantation of an intraocular lens].

In the period of 1985-1992 we performed in our centres 34 operations of a double procedure and 12 operations of a triple procedure. During the observation--from 2 months to 7 years--we obtained favourable results encouraging to connect the corneal grafting with cataract extraction in high myopia and with extracapsular cataract extraction with implantation of an artificial lens in emmetropic eyes. Presented is the appropriate technique of operation and the results obtained.

Adolescent↗
PubMedDate not supplied

Deep lamellar keratoplasty for various corneal lesions.

PURPOSE: To evaluate the efficacy and safety of deep lamellar keratoplasty (DLK) as a method for treating various diseases of corneal stroma with unaffected endothelium. METHODS: DLK was performed in 31 eyes of 31 patients with corneal stroma opacity without endothelial abnormalities. Surgical procedures included deep removal of corneal stroma 7.5 mm in diameter with the use of viscoelastic or 0.02% trypan blue solution, exposing Descemet membrane in the central area of about 5 mm across including the area of pupil, and grafting a corneal lenticule. In three cases of postinflammatory stromal scars with coexisting limbal stem cell deficiency, limbal stem cell grafting was additionally performed. Main outcome measures were best-corrected visual acuity (BCVA) and postoperative astigmatism. RESULTS: Intraoperative perforation of Descemet membrane with the necessity of converting the procedure into penetrating keratoplasty occurred in five cases (16.1%) and one patient underwent penetrating keratoplasty on the seventh day after DLK due to persistent double anterior chamber. These six patients were excluded from the study. Postoperative BCVA ranged from 0.1 to 1.0 and astigmatism from 1.2 to 4.7 D. Postoperative complications were loose sutures, ocular hypertension, Descemet membrane detachment, and corneal melting. CONCLUSIONS: DLK is an effective procedure for treating various diseases of corneal stroma with unaffected endothelium. This technique as an extraocular procedure seems to be the treatment of choice in mentally retarded patients.

Adult↗
PubMedDate not supplied

[Liposomes containing dexamethasone-- ophthalmic ointment].

Presented is the method of production of the liposomal form of dexamethasone. The liposomes have been obtained by the method of manual shaking out. Dexamethasone contained in liposomes MLV was connected with a base forming a 0.05% ophthalmic ointment. The drug prepared in this manner was used in an experimental viral interstitial keratitis in rabbits.

Animals↗