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Biomedical subjects

E Zablocki

Publications and source records attributed to E Zablocki.

At least 19 recordsLinked to original sources
PubMed2000

Brca1 required for T cell lineage development but not TCR loci rearrangement.

Brca1 (breast cancerl, early onset) deficiency results in early embryonic lethality. As Brca1 is highly expressed in the T cell lineage, a T cell-specific disruption of Brca1 was generated to assess the role of Brca1 in relation to T lymphocyte development. We found that thymocyte development in Brca1-/- mice was impaired not as a result of V(D)J T cell receptor (TCR) recombination but because thymocytes had increased expression of tumor protein p53. Chromosomal damage accumulation and abnormal cell death were observed in mutant cells. We found that cell death inhibitor Bcl-2 overexpression, or p53-/- backgrounds, completely restored survival and development of Brca1-/- thymocytes; peripheral T cell numbers were not totally restored in Brcal-/- p53-/- mice; and that a mutant background for p21 (cyclin-dependent kinase inhibitor 1A) did not restore Brca1-/- thymocyte development, but partially restored peripheral T cell development. Thus, the outcome of Brca1 deficiency was dependent on cellular context, with the major defects being increased apoptosis in thymocytes, and defective proliferation in peripheral T cells.

Animals↗
PubMed1999

Partnering with academic institutions to improve population health.

Eager to make the most of local knowledge, hospitals, medical schools and managed care organizations are forming alliances to shape healthcare delivery in their regions. Such collaborations often involve training residents to work within managed care, but others are pursuing disease management and population health improvement.

Academic Medical Centers↗
PubMed1998

Is there a PSO in your future?

A decision to form a provider-sponsored organization and go after the lucrative Medicare market depends on several variables. Chief among them are risk-management and marketing capabilities, strength of the provider network, the potential market and the competition, and availability of appropriate information systems and controls.

Aged↗
PubMed1998

Health plans, providers struggle with quality in alternative medicine.

Consumer demand is pushing many healthcare providers and payers to offer complementary and alternative therapies, from chiropractic to acupuncture, even in the absence of conclusive evidence of their efficacy. To keep patients safe, and to limit costs, organizations are setting strict limits about the type and amount of alternative therapy they will provide.

Complementary Therapies↗
PubMed1998

A new resource: empowered patients.

Patients who have access to healthcare information on the Internet or elsewhere or who have learned to demand interaction with their providers can be intimidating--and also one of a provider's biggest assets. When providers take the time to talk with patients about their conditions, to involve them in decisionmaking and to give them access to information, patients can become active participants in the care process. That shift in roles can reduce inappropriate utilization, cut costs and increase satisfaction.

Chronic Disease↗
PubMed1998

Weight and work.

Explore the source record for details and available documents.

Body Mass Index↗
PubMed1997

Case study. Centura Health--two faiths in alliance.

Threatened with increased for-profit competition, two Colorado hospital systems--one Catholic and the other Adventist--decided to joint forces. Leaders of that alliance--Centura Health--believe it has the edge over its competition because of its not-for-profit status and its geographic coverage, the best in the state. Will Centura succeed? Experts say the jury is still out, but prospects look good.

Catholicism↗
PubMed1997

Government antifraud efforts intensify.

"Business as usual" is going by the wayside as new legislation strengthens penalties for fraud and abuse of federal healthcare contracts. Five experts warn of the consequences and emphasize the need for compliance programs to ensure appropriate billing decisions.

American Hospital Association↗
PubMed1997

Structuring a service line.

In 1993, Community Hospitals Indianapolis created 10 service lines--each unique to the needs of the patients it serves. Two service line leaders talk about the factors critical to successful restructuring, the working relationships established, and the importance of clear communication to ensure understanding and get buy-in to the process.

Cardiology Service, Hospital↗
PubMed1997

Reorganizing patient care around service lines.

Practice makes perfect, the experts remind us. And studies show that the more healthcare providers care for patients with certain conditions, the better that care becomes. In this issue, THE QUALITY LETTER talks with healthcare leaders who have implemented revolutionary changes in the way care has been delivered at most healthcare organizations for more than a century. They've reorganized care within their organizations into product lines or service lines, such as cardiology, oncology and women and children's health. Reorganization has meant establishing new reporting patterns and emphasizing multidisciplinary teamwork. Best of all, they're reaping the benefits that early measurements show, such as reduced hospital length of stay and reduced costs. Healthcare leaders who spoke with THE QUALITY LETTER all agree that such reorganization is worth the effort--and note the four major lessons they've learned about easing the transition to service line delivery.

Child↗
PubMed1997

The economics of managing healthcare delivery systems by service lines.

In their continuing quest for greater efficiency and lower costs without compromising quality of care (and preferably while improving quality), some health system leaders have adopted what is called the "service line" or "product line" approach to healthcare delivery.

Centers for Medicare and Medicaid Services, U.S.↗