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Biomedical subjects

E Zbranca

Publications and source records attributed to E Zbranca.

At least 19 recordsLinked to original sources

[Fine needle puncture--method of treatment in nodular pathology of the thyroid].

Fine needle biopsy (FNB) has been used as a therapeutic method in different nodular lesions of the thyroid. Between 1989-1995, 295 subjects with thyroid cysts, 235 women and 60 men have been treated by FNB. The treatment of cysts was performed by: one or multiple aspirations in 207 cases, sclerosis by injection with tetracycline in 77 cases and by ethanol washing in 11 cases. 263 (89.11%) cases have been cured and we have lost track of 32 cases in the survey. Of the 207 cases treated by aspiration, 177 (86.5%) have been cured after one or more aspirations. Of the 77 cases treated by injections with tetracycline, 75 (97.26%) displayed sclerosis after one or more injections. All 11 cases treated by ethanol washing method displayed sclerosis. Between 1993-1995 we used percutaneous ethanol injection (PE1) in 6 cases, as an alternative to the classic treatment, in order to induce necrosis of toxic adenoma. After 1 to 9 injections all cases were cured, with the appearance of the entire image of the gland on the scintigram. In 4 cases of cold nodules with benign cytology PEI, induced a significant decrease of volume appreciated by sonography.

Adenoma↗

[Secondary hyperparathyroidism].

Secondary (renal) hyperparathyroidism appears in chronic renal failure, sometimes in patients on chronic dialysis. Other causes includes rickets and osteomalacia. These diseases are associated with poor calcium and vitamin D absorbtion from the small bowel. Two patients with chronic renal failure maintained on chronic haemodialysis from two and three years, respectively underwent subtotal parathyroidectomy: removal of three glands and preserving a half of a gland in situ. The diagnosis and surgical indication was made upon clinical (bone pain and severe itching), radiological (demineralisation, ectopic calcifications) and biochemical (hypercalcemia, hyperphosphoremia, increased values of alkaline phosphatases) arguments. Postoperatively the improvement is defined by a return to normal in the clinical, laboratory and radiological parametres. The most appropriate operation for secondary hyperparathyroidism is still unresolved one of two techniques is performed according to the preference of the surgeon: subtotal parathyroidectomy or total parathyroidectomy with autotransplantation of parathyroid fragments into forearm muscle.

Adult↗

[The hyperfunctional thyroid nodule].

Authors report their experience of 22 years regarding 284 patients with hyperfunctional thyroidal nodules (279 operated), representing 12.4% of the 2,289 cases of thyroidal (875 hyperthyroid) diseases treated during this period. The diagnosis was established on the basis of the confrontation of the anamnestic symptomatology and of that found at the clinical examination--which confirmed the pure character of thyrotoxicosis by showing the presence of a thyroidal nodule--with the study of the global glandular function and the scintigram, completed with dynamic tests. Among the typical clinical and scintigraphic, usually severe, forms (with cardiothyreosis) may be distinguished asymptomatic or atypical forms (with dissociated or intermittent manifestations). The treatment of the toxic thyroidal adenoma is surgical, except some contraindications of a general order. The surgical treatment is aimed at achieving the permanent cure of the disease, without sequelae or functional and/or morphological relapses. The subtotal lobectomy (210 cases) is preferred as an exeresis procedure to the enucleoresection (45 cases). In most operated cases (93%) the immediate clinical and biological results were favourable.

Adolescent↗

Hormonal treatment in prostate cancer.

Prostate cancer is one of the most current diseases in elderly men and contributes greatly to the increase in mortality, morbidity and cost of health care. An adequate therapeutical approach requires a whole set of methods for establishing a correct histologic diagnosis and evaluating the local and general spread of the disease. As most of the neoplastic cells in the prostate are at least partly androgen-dependent, the goal of the hormonal therapy is to deprive them of androgenic hormones and their derivatives. On this purpose, the most important means of the hormonal therapy, starting with the traditional ones (orchidectomy, hypophysectomy, adrenalectomy, androgens administration) and ending with the latest achievements (anti-androgens, antiestrogens, LH--RH analogous) are scrutinized, making specific recommendations as to their indications, way of administration and effectiveness.

Adenocarcinoma↗

[The use of echography in the diagnosis of autoimmune thyropathies].

Ultrasonography is a first line method in thyroid imaging. The aim of this study was to evaluate the usefulness of thyroid ultrasonography in the diagnosis of thyroid autoimmune diseases (TAD): Graves' disease (GD) and autoimmune thyroiditis (AT)--Hashimoto's and atrophic thyroiditis. Ultrasonography was performed with a 7.5 MHz transducer in 1033 consecutive patients. The excluding criteria was nodular goiter, irrespective of its function. Thyroid volume was calculated using the formula of a rotating ellipsoid. Hypoechogenicity was appreciated using a qualitative scale: 1 = absent, 2 = mild, 3 = moderate, 4 = marked. In patients with TAD thyroid hypoechogenicity was significantly higher than in normal subjects (2.5 +/- 1 in GD and 2.7 +/- 1 in AT, vs. 1.2 +/- 0.6 in normal subjects, p < 0.0001). The specificity of the test in identifying TAD was 91.4%, the sensitivity was 68.6% for GD and 80.8% for AT, positive predictive value was 91.5%, and negative predictive value 91.5%. Ultrasonography is useful in identifying patients with probable autoimmune thyroid diseases, being useful in epidemiological studies and having an important contribution in confirmation of the diagnosis.

Adult↗

[Cephalometric changes in acromegaly].

Acromegaly represents the endocrine disease which includes the somatic and metabolic disorders secondly resulting to the augmentation of the Growth Hormone secretion after the growth cartilages closing (in adult). In this case we can find very important troubles which characterize all the specific elements of the stomatognathic system. The cranio-facial skeleton has a specific configuration, the mandible is developed in excess and the relationships between the maxilla, the mandible and the skull are strongly modified. These and the structural bony troubles, the bony asymmetries involve periodontal, muscular and articular disturbances. In this study we want to describe the craniofacial cephalometric qualitative and quantitative disorders and to emphasize their implications in the onset and the evolution of the stomatognathic system dysfunctional syndrome.

Acromegaly↗

[A rare form of osteopoikilosis].

The authors report a typical case of osteopoikilosis striata Voorhoeve in a 51-years-old female. In connection with case they make some consideration concerning the diagnostic of this very infrequent sclerotic bone dysplasia.

Adenoma↗

[An analysis of the evolution of body compartments in anorexia nervosa--the bioelectrical impedance method].

Body compartments can be assessed by means of bioelectrical impedance, a non-invasive, cost saving and simple physical method. The purpose of this study was to estimate the body compartments in anorexic patients, in the under-nutrition phase (group BMI < 17 kg/m2) and after weight restoration (BMI > 17 kg/m2). Total body water, intracellular and extracellular water have significantly decreased after weight restoration. The fat mass significantly (p < 0.001) increased in group BMI > 17 kg/m2 compared with group BMI < 17 kg/m2, and we have found a positive correlation between body mass index (BMI) and fat mass (r = 0.73, p < 0.0001). The assessment of free fat mass can provide information about the under-nutrition degree and the quality of re-feeding. The increase of free fat mass was significant (p < 0.001) in the group BMI > 17 kg/m2 as compare with the group BMI < 17 kg/m2). We have found a positive correlation between free fat mass and BMI (r = 0.73, p < 0.0001).

Adolescent↗

[The correlations between the electromyographic display and the aspects involved with masticatory muscle contraction and phosphorus-calcium metabolism].

The neuromuscular activity at the level of the stomatognathic system has a specific complexity, due to the multiple systemic functions, realizing the statistical and dynamical mandibular positions and the integration of the stomatognathic system at the level of the human body. Knowing that the neuroendocrine system represents an important factor for the over-systemic coordination of the stomatognathic muscular activity, we want to establish the implication and the neuroendocrine correlation in the stomatognathic muscular dysfunctions determined by some endocrine diseases.

Calcium↗

[Changes in the craniomandibular relations of acromegaly patients].

The dishomeostazical theory (etiopathogenic integrative concept) allows an ample and complex vue on the stomatognathic system dysfunctional syndrome, because it begins from the perception of the stomatognathic system (SS) as a whole in which the alteration of each element can induce the disfunction of the entire system. The purpose of this study is to demonstrate that the neuroendocrine suprasystemic factor (STH hypersecretion on adult organism) disturbs every element of the SS and induces an important alteration of the fundamental cranio-mandibular relations.

Acromegaly↗