Biomedical subjects

E Zemberová

Publications and source records attributed to E Zemberová.

8 recordsLinked to original sources

PubMed2003

[The thyroid gland in women during the reproductive age].

OBJECTIVE: To find out thyroid volume and its functional status in women in reproductive age as well as possible correlation between thyroid size and functional status and age and residential location of women. DESIGN: Project can be characterized as an epidemiological study and consists of three separate observations. SETTING: 1st Internal Clinic, UPJS, Kosice, Medical Faculty, Slovakia. METHODS: 347 women from different regions of Eastern Slovakia (160 aged 20-29 and 187 aged 30-40) were measured thyroid volume via ultrasonography and thyroid functional status by RIA TSH and anti TPO examinations. Urinary iodine was examined in 70 cases. In this part of the study correlation between thyroid size and functional status and age and residential location of women were determined. Four days after delivery thyroid volume in 99 women was measured. The volume was correlated with the number of previous pregnancies. Thyroid volume was correlated with residential location and number of pregnancies of 77 women that had not delivered in the previous year. RESULTS: Women aged 20-29 years had thyroid volume smaller than women aged 30-40 (8.78 ml/10.66 ml; p < 0.01). The size of thyroid gland was not only affected by age but also by residential location. The largest thyroid glands and increased level of anti TPO antibodies in both age groups were found in women from agricultural regions and regions close to chemical factory. The women with anti TPO antibodies had increased level of TSH as well as more frequently changed echogenity of thyroid gland. Median of urinary iodine was 13.2 micrograms/dl in both age groups and indicated sufficient iodine intake in the observed area. The volume of thyroid gland four days after delivery did not exceed 22 ml in 89.9% of cases. Significant difference in size of thyroid gland depending on number of previous deliveries was not only observed in women 4 days after delivery but also in those that had not delivered during previous year. The largest volumes were measured in secundiparous mothers. CONCLUSION: Polluted environment affects the size and functional status of thyroid gland. Environment can via this negative impact on thyroid gland influence fertility, pregnancy and fetus development in women in reproductive age.

Adult↗

PubMed2001

[Effect of nitrates on active transport of iodine].

Active iodine transport into the thyrocyte is catalyzed by the transmembrane transport protein Na+/J- symport (NIS) Nitrates can expel iodine from the bond with this transport protein which was found not only in the thyrocyte membrane but also in the cell membrane of the gastric mucosa. The weight of the thyroid gland in mg was significantly greater even when calculated in relation to body weight in the NIT group of rats who were given for 6 days nitrate by gastric tube (100 mg/kg/day) as compared with controls (CON) 17.56 +/- 8.4, 0.07 +/- 0.03/12.10 +/- 9.57, 0.05 +/- 0.03, P < or = 0.01. A lower thyroid activity in per cent calculated per 1 mg of its weight (1.39 +/- 1.0/2.22 +/- 0.9, P < or = 0.01), a higher activity in blood before removal of the thyroid gland (8.54 +/- 4.09/5.45 +/- 2.78) and a lower one after removal of the thyroid gland (1.09 +/- 0.05/0.21 +/- 0.10) before oral administration of I131 in group NIT, suggests a negative effect of nitrates on active iodine transport not only at the level of the thyrocyte but also possible interaction with iodine at the level of the digestive tract. A significantly higher serum level of TT3 in group NIT (0.66 +/- 0.27/0.44 +/- 0.21, P < or = 0.01 regardless of the TSH serum level (2.31 +/- 1.83/2.64 +/- 1.52) and T4 (22.72 +/- 8.2/25 +/- 11.0) suggests a qualitative change in thyroid hormone production in favour of T3 caused even by short-term nitrate administration.

Animals↗

PubMed1999

[The renin-angiotensin-aldosterone system and serum lipoproteins in patients with essential hypertension].

The authors investigated the relationship between the activity of the renin-angiotensin-aldosterone system and serum lipid levels in patients with essential hypertension (EH). They examined 72 patients with EH stage I and II WHO classification (group A, n = 72, age bracket 16-70 years). They investigated the plasma renin activity (PRA), plasma aldosterone (PA) and total cholesterol (TCH), HDL, LDL cholesterol and triglycerides (TG). They divided the group into three sub-groups according to the PRA into low (L), normal (N) and high renin groups (H) In the whole group they did not find significant differences in the lipid levels in relation to PRA. They selected from the group patients older than 40 years (group B) and in those they recorded significantly higher TCH levels in group H as compared with normal (N) (p < 0.05) and L (p < 0.05) and significantly higher LDL levels in group H as compared with L (p < 0.01). They found a significant direct relationship between PRA and TCH (p < 0.05) and between PRA and LDL (p < 0.01), a liminal relationship between PA and TCH (p = 0.05). They did not find a significant relationship between the RAAS activity and HDL or TG. The authors conclude that patients with EH above 40 years and high PRA a markedly greater hyperlipoproteinaemia as compared with the low- or normal-renin group. This may partly explain the higher incidence of cardiovascular complications in high-renin EH reported by some authors.

Adolescent↗

PubMed1998

Peritoneal clearance and peritoneal transfer of oxalic acid, vitamin C, and vitamin B6 during continuous ambulatory peritoneal dialysis.

The peritoneal clearance and peritoneal transfer of oxalic acid, vitamin C, and vitamin B6 in 32 patients during continuous ambulatory peritoneal dialysis (CAPD) using peritoneal dialysis solutions containing 1.5% or 2.5% glucose were examined. The plasma level of oxalic acid was significantly elevated in all patients, plasma vitamin C was in the normal range or in the upper margin of the normal range, and plasma vitamin B6 was in the normal range. The peritoneal clearance of oxalic acid was significantly lower, and the peritoneal clearance of vitamin B6 was the lowest in comparison to the peritoneal clearance of urea. With the exception of vitamin B6, the peritoneal clearance and peritoneal transfer of the examined parameters increased using the dialysis solution containing 2.5% glucose. We found direct relationships between the plasma levels of oxalic acid and creatinine as well as plasma vitamin C and between the peritoneal transfer of oxalic acid and the peritoneal transfer of vitamin C as well as vitamin B6. The significant hyperoxalemia of our patients was found to persist despite the relatively high peritoneal transfer of oxalic acid during CAPD. These results suggest that CAPD is not a method effective enough for permanent reduction of the plasma levels of oxalic acid.

Adult↗

PubMed1998

[Changes in thrombocyte aggregation in primary hypothyroidism].

The authors examined the thrombocyte aggregation in 10 controls and 17 patients with the diagnosis of primary hypothyroidism before and after 2 months substitution treatment with levothyroxine. They recorded a significantly reduced intensity of the aggregation response in untreated patients as compared with controls after adrenaline (p < 0.01), ADP (p < 0.01) but not after ristocetin. Impaired thrombocyte aggregation was observed in 11 of 17 patients, i.e. in 65%. After treatment the thrombocytopathy improved in 7 of 11 patients (63%), in four it persisted. Except one female patient the thrombocytopathy improved in all patients with manifest hypothyroidism. In patients with the latent form of hypothyroidism probably an independent coincidence of elevated TSH levels and impaired thrombocyte function was involved. The authors did not detect any cases of acquired von Willebrand's disease. In the conclusion the authors mention that impaired thrombocyte aggregation is a frequent phenomenon after thyroxine treatment. It may be of clinical significance when combined with other changes of haemostasis or in conjunction with the use of some drugs.

Adult↗

PubMed1998

[The effect of furosemide on urinary excretion of oxalic acid, vitamin C and vitamin B6 in chronic kidney failure].

The authors describe the effect of a single i.v. dose of 20 mg furosemide on the excretion of oxalic acid, vitamin C and vitamin B6 in a control group and in patients with chronic renal failure without dialyzation treatment. An increased urinary excretion of oxalic acid, vitamin C and vitamin B6 was found during the first three hours after furosemide administration in both groups. The effect of furosemide persisted for six hours in patients with chronic renal failure without dialyzation treatment. The authors described a new hitherto unknown positive side-effect of furosemide, i.e. enhanced urinary oxalic acid excretion in the control group and in patients with chronic renal failure without dialyzation treatment and a negative side-effect of furosemide, i.e. increased urinary vitamin B6 excretion in both examined groups. With regard to the assembled results the authors recommend in addition to monitoring of vitamin C also monitoring of vitamin B6 in plasma during long-term administration of large doses of furosemide to patients with chronic renal failure as deficiency of these vitamins could develop.

Adult↗

PubMed1997

Metabolism of vitamin B6 and its requirement in chronic renal failure.

Vitamin B6 is very important for the normal function of multiple organ systems. In the majority of patients with chronic renal failure and in patients during various forms of renal replacement therapy can develop vitamin B6 deficiency from many causes. Intravenous administration of 20 mg furosemide led to the increase of urinary excretion and fraction excretion (FE) of vitamin B6 in patients with chronic renal failure. This is a new side effect of furosemide. The daily oral dose of pyridoxine 6 mg was optimal for the patients without erythropoietin (EPO) treatment during the period of 12 months of CAPD. Erythrocyte vitamin B6 was determined by an indirect method, that is, by measuring the effect of pyridoxal-5-phosphate (PLP). In the other group of CAPD patients plasma vitamin B6 was in the reference range, and the mean value of peritoneal clearance of vitamin B6 was very low: 8.8% of urea clearance. In addition, an indirect relationship between the effect of PLP and plasma vitamin B6 was found. Indirect evidence has shown that erythrocyte vitamin B6 is consumed by the hemoglobin synthesis much more during EPO treatment in hemodialysis patients. No influence of pyridoxine 5 to 6 mg/day on decreased parameters of cellular immunity was found. For prevention of vitamin B6 deficiency in hemodialysis and CAPD patients we recommend the following doses of pyridoxine: for patients without EPO treatment 5 mg/day, and with EPO treatment 20 mg/day. A favorable effect of pyridoxine 50 mg/day has also been found on several parameters of cellular immunity in hemodialysis patients.

Adult↗

PubMedDate not supplied

Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B(6), oxalic acid and vitamin C in chronic renal failure.

Urinary excretion of vitamin B(6), oxalic acid and vitamin C was investigated in 15 healthy subjects during maximal water diuresis and in the group of 12 patients in polyuric stage of chronic renal failure without dialysis treatment receiving a diet containing high sodium chloride (15g/day). Urinary excretions of the same parameters were investigated in another group of 15 patients in polyuric stage of chronic renal failure without dialysis treatment after i.v. administration of 20 mg furosemide. Urinary excretion of vitamin B(6), oxalic acid and vitamin C significantly increased during maximal water diuresis while during high intake of sodium chloride the urinary excretions of these substances were not affected. The results suggest that urinary excretion of vitamin B(6), oxalic acid and vitamin C depends on the urinary excretion of water. Intravenous administration of 20 mg furosemide led to an increase of urinary excretion of vitamin B(6), oxalic acid and vitamin C in patients with chronic renal failure. The increased urinary excretion of vitamin B(6) and vitamin C is a new negative side effect of furosemide and increased urinary excretion of oxalic acid is a new positive side effect in patients with chronic renal failure.

Adult↗