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Biomedical subjects

E Ziółko

Publications and source records attributed to E Ziółko.

8 recordsLinked to original sources
PubMed2001

[Evaluation of quality of life in patients with advanced colorectal cancer treated with topotecan].

UNLABELLED: During last years a few new directions appeared in therapy of advanced colorectal cancer. Topotecan, a camptothecin analog, seems to be one of the promising novel drug in these cases. Its unique mechanism of action is connected with inhibition of the nuclear enzyme topoizomerase I. Assessing therapeutic effects of new cytotoxic drugs we should consider their impact on survival time and quality of life as well. The aim of our study was the attempt to assess the quality of life of patients with advanced colorectal cancer (IV stage in TNM scale), treated by topotecan. Clinical trial was performed in the group of 10 patients. Topotecan was administered intravenously at 1.5 mg/m2/day for 5 days and repeated every 21 days. Quality of life assessment was performed at special time points using Rotterdam Symptom Checklist. We observed improvement in quality of life in six out ten patients having advanced colorectal cancer. Two patients did not show any change in quality of life and two patients with progression of disease demonstrated lower quality of life during topotecan treatment. CONCLUSION: Topotecan has a positive influence on quality of life of patients with advanced colorectal cancer. Further study are needed to confirm this observation.

Aged↗
PubMed2001

[Endolymphatic therapy].

Using physiological function of lymphatic vessels and nodes and also a fact that they are a frequent place of spreading of diseases, there are attempts of endolymphatic therapy--it means drug infusions into lymphatic vessels for the purpose of penetrate lymphatic nodes engaged by disease. There are more and more attempts of using the cytostatics placed in liposomes in endolymphatic.

Antineoplastic Agents↗
PubMed1997

[Beautiful literature and audiovisual media provide a change to stimulate human creativity].

The aim of this study was the attempt to determine which films and books had an influence on the mental resources of medical students. We used a special form, created in accordance with the group thinking theory called "brain storm on a paper". We examined 111 six year medical students taking part in the workshops. Each group of students consists of 9-12 persons. It was impossible to describe and analyze in that paper all novels which made the impression on the examined students. The obtained outcomes indicated that the progress of young people mentality was limited by simple and traditional ground basis. That basis was consisted of obligatory set books and actually popular films. There were only a few items which were to teach an optimism or to promote an active and creative attitude to the life. In our opinion that findings should be very important to every person who cares for a mental condition of young people.

Audiovisual Aids↗
PubMed1997

[Effectiveness of combined therapy in patients with clear cell carcinoma of the kidney].

The paper presents preliminary results of a combined therapy consisted of INF-alpha, TNF-alpha and Vinblastine administrated to 12 patients with advanced clear cell carcinoma of kidney. All patients accrued into this protocol underwent unsuccessful conventional oncological treatment. In 2 subjects the treatment was interrupted because of acute adverse events during the first course of the combined therapy. In the remaining group: 3 patients showed long term partial remission (PR) (follow up time up to 9.5 months) and 4 patients responded with minor/stable disease. The disease progression was observed in 2 patients.

Adenocarcinoma, Clear Cell↗
PubMed1997

[A trial of applying an oily suspension of bleomycin endolymphatically in patients with Hodgkin's disease of the extraperitoneal lymph nodes].

This study summarized results of treatment of the extraperitoneal lymphatic nodes in patients with Hodgkin's disease with infusion of oily form of bleomycin into the lymphatic vessels. Sixty patients aged 17-69 yr. (mean 43 yr.), 24 women and 36 men with Hodgkin's disease staged IIIA-IVB after 6 cycles of chemotherapy with MOPP or MOPP/ABVD were investigated. Three months after the last cycles of chemotherapy neoplastic changes in the extraperitoneal lymphatic nodes were found in 18 patients only. These patients were treated with bleomycin injected within 30 min. in a daily dose of 30 mg up to total dose 60 mg. Total remission was found in 7 patients, in 4 patients the nodes were shrunken and in the remaining 7 patients there was no visible sings of the disease. Serum level of bleomycin was the highest a few minutes after injection (217-680 ng/ml) and was followed rapid decrease. The obtained results have led to the following conclusions: 1. Oily suspension of bleomycin is a method of chose in the treatment of patients with Hodgkin's disease with changes in the extraperitoneal node. 2. High dose of bleomycin applied directly to the lymphatic vessels leads to total or subtotal remission of the nodal changes. 3. The highest serum concentration of bleomycin was found after the injection. 4. The method in painless and safe the patients, fever may occur for a few hours only.

Adolescent↗
PubMed1995

Serum levels of bleomycin released from the lymphatic system.

Endolymphatic injection Oil-Bleo (Nippon Kayaku, Japan) was performed on 24 patients for treatment of residual retroperitoneal malignant lymphoma detected after intravenous chemotherapy. The drug was administered once only in a dosage of 60 mg/30 mg per foot. Serum levels of the drug were monitored. The results were compared with data obtained after routine intravenous infusion of aqueous bleomycin to patients with advanced cervical cancer. The results revealed that bleomycin administered intralymphatically reaches maximum concentration after 15 minutes, and bleomycin after intravenous administration reaches maximum concentration at 36 hours.

Bleomycin↗