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E Zocconi

Publications and source records attributed to E Zocconi.

6 recordsLinked to original sources
PubMed2006

HPV genotyping and HLA II analysis in a pedigree study of pediatric RRP: preliminary results.

OBJECTIVE: This preliminary pedigree study aims at the evaluation of HPV infection and HLA class II alleles as predictive markers in pediatric RRP. METHODS: We investigated for HPV genotyping and HLA class II polymorphisms all the components of family nucleus where we detected a child born to an HPV infected mother and suffering from RRP. RESULTS: HPV 11 was detected both in the laryngeal biopsies of two of the three affected babies and in the cervical smear of their mothers. The third child was positive for HPV 6 while his mother harboured a double HPV 6-16 infection. In one family, the HLA-DQB1*0501 allele exerted its protective role. The HLA-DQB1*0301 allele, commonly associated to a high grade of cervical neoplasia and HPV infection, was present in homozygous in one mother and her child. The same allele was found, though in a heterozygous form, in the third patient too. CONCLUSION: Our report is the first attempt to use the pedigree study for the evaluation of HLA class II alleles and HPV infection related to pediatric RRP. This approach could identify genetic markers that may influence disease predisposition and the severity of HPV infection.

Alleles↗
PubMedDate not supplied

[Antibiotics and cortisone in the treatment of otitis media with effusion].

Persistent otitis media with effusion (OME) is a pathology very frequent in the first year of life and causes hearing loss which can be a negative factor in language and cognitive development and may result in disturbances in psychological adjustment. Generally OME has spontaneous resolution but if it persist for more than 3 months a medical or surgical treatment is compulsory. OME is frequently a result of recurrent otitis media and bacterial infection is considered to play a definitive causative role in the development of this pathology. A wide variety of medical treatments (antibiotics, aerosolized corticosteroids, oral antihistamine-decongestants, mucolytics) is indicative of lake of success. We have treated 60 children with OME with antibiotics (amoxicillin or cefaclor for 1 month) and oral steroids (prednisone for 7 days). All patients had a history for more than 3 months, without adenoid hypertrophy. Diagnosis of OME was established after pneumatic otoscopy, tympanometry and audiometry. Following the therapeutical association 53 patients showed a complete resolution of the effusion. At the follow-up after 2 months, 4 children had a recurrence of effusion. We consider this treatment with a short course of steroids and antibiotics and effective method before referral for tube placement.

Amoxicillin↗
PubMedDate not supplied

[Tonsillectomy and adenoidectomy in children of 1 and 2 years].

The aim of this paper is evaluate the risk and the benefit to tonsillectomy and adenoidectomy in very young children. Between January 1989 and May 1993 we have operated on 166 children less than 3 years old (98 adenoidectomies and 68 adenotonsillectomies). 19 one year old children were submitted to adenoidectomy and 7 to tonsillectomy, the youngest was 7 months old. The indication for adenoidectomy were prevalent mouth breathing, snoring and recurrent otitis media; the criteria for tonsillectomy have been obstructive sleep problems, history of snoring, eating and swallowing disorders (97% of cases) and recurrent viral tonsillitis (3% of cases). All operation were performed under general anesthesia with children in Rose position. Postoperatively no antibiotics were given and only one dose of analgesic drug. We have never used aspirin either before or after surgery. No child had postoperative bleeding. No child has been readmitted for dehydration. We conclude after this study that tonsillectomy and adenoidectomy can be a safe procedure also in very young children.

Adenoidectomy↗
PubMedDate not supplied

[The lexical aspects in children with expressive language delay].

This study examines the lexical characteristics of language development of 17 children between 24 and 41 months of age with a history of slow expressive language acquisition (experimental group). The purpose of the investigation is to compare these subjects to 49 children (ranging in age from 13-24 months) with a normal language history matched for vocabulary size to determine, whether the expressive vocabulary of children with language delay is same to normal group. The data were collected using the parental report instrument "Il Primo Vocabolario del Bambino"(Caselli and casadio 1995) the Italian version of MacArthur Communicative Development Inventories (Fenson et al. 1993). For analyses of word production, children were divided into four groups based on their total vocabulary size: 1) 11 to 20 words; 2) 21 to 50 words; 3) 51 to 100 words; 4) 101 to 200 words. Analysis revealed a significant difference in verbs and grammatical function words when the level of vocabulary size of experimental group was between 21 and 50 words. In the other vocabulary size there were not significant differences. In summary the results of this study show that the vocabulary composition of children with slow expressive language acquisition is same that of children 14-16 months younger.

Child, Preschool↗