Biomedical subjects

E Zuskin

Publications and source records attributed to E Zuskin.

At least 163 records · Page 9Linked to original sources

PubMed1975

Byssinosis: airway responses in textile dust exposure.

The inhalation of textile dusts causes bronchoconstriction in textile workers and in healthy experimental subjects. The airway responses to these dusts are potentiated by propranolol and inhibited by an antihistamine drug and by ascorbic acid. Administration of 20 mg disodium cromoglycate by spinhaler 30 minutes prior to challenge with hemp dust or hemp dust extract protected a small number of subjects against the airway constrictor effect, mostly those with a large acute reduction in flow rates. Textile dust extracts contain a histamine-releasing agent, which explains their airway constrictor effect. This agent is a highly water-soluble, heat-stable, low-molecular-weight compound which has not yet been chemically identified. In the prevention and control of byssinosis, the administration of drugs such as ascorbic acid or disodium cromoglycate should be considered in addition to engineering methods.

Adult↗

PubMed1975

Lung function in textile workers.

Acute changes in ventilatory function during a workshift with exposure to hemp, flax, and cotton dust were measured on Mondays in a group of 61 textile workers, all working on carding machines. In addition, single-breath diffusing capacity (DLCOSB) was measured before dust exposure on Monday in 30 of the 61 workers. Large acute reductions during dust exposure were recorded in maximum expiratory flow rate at 50% VC (MEF50%), ranging from 38 to 22%. Acute reductions of FEV1-0 were considerably smaller, ranging from 17 to 9%. There was a statistically significant increase in residual volume (RV) with very small and insignificant changes in total lung capacity (TLC). Although preshift FEV1-0 and FVC were decreased, DLCOSB was within normal limits. Plethysmographic measurements in six healthy volunteers exposed to hemp-dust extract confirmed the results obtained in textile workers, that is, that TLC does not change significantly during dust-induced airway constriction and that maximum expiratory flow rate at 50% VC (MEF50%) is a more sensitive test than FEV1-0 in detecting acute ventilatory changes caused by the dust extract.

Adult↗

PubMed1975

Change in the respiratory response to coarse cotton dust over a ten-year period.

Changes in respiratory function during a 10-year period were studied in a group of 34 men and 19 women exposed to coarse cotton dust. The prevalence of byssinosis increased significantly in the 10-year period both in men and women; in addition, there was an increase in the prevalence of all other chronic respiratory symptoms in 1973 compared to 1963. There was a significant decrease in forced expiratory volume in 1 sec and forced vital capacity over the Monday shift both in 1963 and 1973. In subjects who were without byssinosis in 1963 but who had developed it by 1973, there was a considerable decrease in forced expiratory volume in 1 sec in 1973. The mean annual decline of forced expiratory volume in 1 sec (70 ml) during the 10-year period in the men was much greater than expected on the basis of the prediction equation for normal males, and it was most pronounced in those with byssinosis at the time of both surveys (111 ml).

Adult↗

PubMed1974