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Biomedical subjects

E de Campora

Publications and source records attributed to E de Campora.

At least 19 recordsLinked to original sources
PubMed2003

Neuroplasticity of auditory cortex after stape surgery for otosclerosis: a magnetoencephalographic study.

Aim of the present study was to investigate the tonotopic reorganization of the primary auditory cortex in otosclerotic patients following functional stapedioplasty. Characteristics of auditory cortex activation have been evaluated in a series of 10 otosclerotic patients before and after surgery. In these patients, a magnetoencephalographic recording of evoked magnetic fields has been performed by means of tone-burst monoaural stimulation with frequency octaves between 250 and 2000 Hz. Brain topography of cortex response generators (wave N100m) in patients with otosclerosis has been compared with that observed in a control group of 10 healthy subjects: changes before and after surgery have also been correlated with the functional result as far as concerns improvement in hearing. A significant reduction has been observed in the cortical tonotopic extension in response to the acoustic stimulus in patients "pre-surgery" in comparison with controls: after surgery, tonotopic mapping showed an increase, dimensions becoming comparable to those in control subjects. This increase in size was found to be significantly correlated with duration of the post-operative period. Data emerging from the present study suggest that the cortical auditory areas in man are involved in a "plastic" functional reorganization following changes in the receptor or peripheral deprivation. Reduction in the cortical tonotopic mapping resulting from prolonged lowering of auditory "input" is modified by reorganization of the cortex after the recovery of auditory function: this process occurs over a period of a few weeks.

Adult↗
PubMed2001

External versus endoscopic approach in the surgical treatment of glottic cancer.

Laryngeal carcinomas in the early stages of evolution can be treated by different therapies. In this paper we present our personal experience with T1 and small T2 laryngeal glottic cancer treated by conventional surgery and by endoscopic laser surgery. In the period 1983-1997, we saw 573 patients affected by T1 and limited T2 glottic tumours. In particular, we treated 325 case of T1a tumour, 185 T1b and 63 T2 (ventricle floor). As regards surgical techniques, we employed cordectomy by laryngofissure in 196 patients; laser cordectomy in 129 cases; widened laser cordectomy in 63 cases; fronto-lateral laryngectomies according to Leroux-Robert in 110 patients; laser cordo-commissurectomies in 37 cases; horizontal glottectomies according to Calearo-Teatini in 9 cases, and laser glottectomies in 29 patients. The average oncological results, considered for every stage and every surgical technique were 84.4% (484 cancers definitively controlled by primary surgery). For comparison of oncological and clinical results, we evaluated patients affected by tumours with similar extension that had been treated by different surgical techniques. Oncological results were similar in the two groups. In the group treated by laser surgery we found a shorter clinical course and the best possibility of salvage therapy in the case of local recurrence.

Aged↗
PubMed2001

[Glottic-hypoglottic laryngectomy in the treatment of laryngeal tumors].

Subglottic cancers and glottic cancers with subglottic extension are considered extremely serious because they are not easily detected and are normally quite advanced when diagnosed. Furthermore these cancers spread rapidly beyond the larynx to the lymph nodes (cervical and recurrential chains). Total laryngectomy is elective surgery in the treatment of subglottic cancer. However, in selected cases, small tumors may also be treated successfully with partial glottic-subglottic laryngectomy. The aim of this paper is to present a personal experience with partial surgery in the treatment of subglottic cancer. The surgical operation consists of the resection of both vocal cords, the subglottic region and the cricoid cartilage with the proximal tracheal rings. The larynx is reconstructed through a tracheal-thyroid approach. The surgical technique is illustrated and the authors' experience discussed.

Aged↗
PubMed1999

Neurogenic tumors of the head and neck in children.

Soft tissue tumors make up 63% of all tumors in children. Tumors of the sympathetic chain make up 7.4% of tumors arising in children (nine new cases a year for every million children in USA) while neurofibrosarcomas make up 3.4% (2.4 new cases per year for every million children). There is a certain difference between the frequency of benign forms (rather elevated) and that of malignant forms (rather low). Diagnosis is possible by echo-scan, computed tomography, magnetic resonance imaging and fine-needle aspiration biopsy. As regards therapy, surgical resection represents the treatment of choice. In our experience, 35 neurogenic tumors in pediatric patients (8-16 years), arising in head and neck spaces, were observed and treated in the period 1976 and 1995. Twenty-six cases were schwannomas, six were neurofibromas and three were olfactory neuroblastomas. All the patients underwent surgery. Sacrifice of the affected nerve was necessary in 12 cases (all neurofibromas and eight neurinomas). In one case of olfactory aesthesioneuroblastoma a combined approach (extra-intracranial approach) was employed. Two patients are alive and disease-free with 5 and 7 years follow-up. As regards dysfunctional pathology following surgical resection, we report definitive facial nerve palsy in two cases, permanent laryngeal palsy in six cases, tongue dysfunction in one case and cheek hypoaesthesia in one case.

Adolescent↗
PubMed1994

Clinical experiences with surgical techniques and treatment results in patients undergoing subtotal laryngectomies.

After a period of critical evaluation, subtotal laryngectomies are now considered to be valuable additions to the surgical management of laryngeal neoplasms. It is now possible to obtain good functional and oncological results in treating clinical situations that until a few years ago appeared curable only by radical surgery. We now report our clinical experiences with Labayle and Majer-Piquet types of subtotal laryngectomies and discuss indications and contra-indications to such surgery. Our current preference is to use Labayle technique, since it permits better functional recovery and a shorter clinical course.

Adult↗
PubMed1994

Clinical experiences with surgical therapy of cervical metastases from head and neck cancer.

Indications for the various techniques of neck dissection can undergo substantial variations according to the metastatic picture found, biological aggressiveness of tumor, nodal volume and personal philosophies of the attending clinician. In the present paper we report our clinical experience with radical neck dissections, "functional" neck dissections and selective neck dissections-in total, 1658 neck dissections carried out between 1976 and 1991. We discuss the indications and contra-indications of the various surgical techniques of neck dissection and evaluate the long-term results. Our current preference is to use the Suarez-Bocca "functional" technique of neck dissection for prophylactic treatment of the neck and for therapeutic treatment of the neck when intracapsular metastases already exist.

Combined Modality Therapy↗
PubMed1985

Thornell's approach for arytenoidectomy in the surgical treatment of bilateral abductor paralysis; personal experience and results.

Surgical treatment of bilateral abductor paralysis of the vocal cords is still a question for debate, as can be seen by a review of the relevant literature. The authors describe their modification of Thornell's technique, as used in 12 cases of recurrent paralysis, and they suggest a variant to the basic method which has been proved to cause minimal trauma, is simple to carry out and has produced excellent results.

Adult↗
PubMed1984

Conservative trans-mandibular approach in the surgical treatment of tumors of the parapharyngeal space.

The authors suggest a conservative transmandibular approach for the surgical treatment of large latero-pharyngeal tumors extending towards the base of the skull. This technique, which may seem more radical and complex is, however, a more logical and conservative approach; and, owing to the excellent surgical field, it is able to keep the delicate surrounding structures intact and to reduce the risk of hemorrhagic and/or neurological complications.

Humans↗
PubMed1983

Characteristics of the association between salt intake and blood pressure in a sample of male working population in southern Italy.

A possible association between dietary salt intake and blood pressure was investigated in an unselected sample of 188 healthy Neapolitan men. In univariate analysis diastolic pressure was positively correlated with age, body mass index and 24-h excretion of sodium, potassium and creatinine, but not with urine volume or sodium: potassium ratio. Systolic pressure was also related to age, body mass index and 24-h sodium, but to a lesser degree. As a high level of intercorrelation was apparent, multivariate analysis was also carried out. Body mass index was shown to be the variable having the largest influence on diastolic pressure variability: nevertheless a significant independent role was still found for 24-h urinary sodium when the latter was included in a regression along with body mass index, age, urine volume and potassium excretion. These results seem to support the possibility that dietary salt has a substantial influence on blood pressure levels.

Adult↗