PubMed Health⌕ Search

Biomedical subjects

Edward Lowe

Publications and source records attributed to Edward Lowe.

4 recordsLinked to original sources
PubMed2004

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding domain and a formerly unidentified protein fold. Moreover, the disposition of key N-glycosylation sites reveals how specific sugar chains could alter both the affinity and avidity of CD44 HA binding. Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies.

Amino Acid Sequence↗
PubMedDate not supplied

A delayed subopaquing technique for treatment of stained dentition: clinical protocol.

Teeth with severe tetracycline staining can present a restorative challenge to the clinician. While a variety of options facilitate predictable aesthetic treatment of patients with such dentition, they often require significant tooth reduction in order to provide the dentist and the laboratory technician with adequate space for the restorative material to conceal the discoloration. This presentation outlines an alternative to this treatment that uses resin cement to mask the discolorations prior to the cementation of the porcelain laminate veneers.

Anti-Bacterial Agents↗