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Biomedical subjects

Edward Rudzki

Publications and source records attributed to Edward Rudzki.

5 recordsLinked to original sources
PubMed2003

[The development of allergy to antibiotics].

The paper includes a survey of issues concerning evolution of allergy to antibiotics. Particular attention is paid to penicillin allergy as this antibiotic has been the drug most frequently causing sensitization since 1960s until today, although the frequency of the allergy is continuously decreasing. In addition, the paper deals with the importance of replacing benzyl penicillin with semi-synthetic penicillins and the impact of these process on the nature of immune response (a decrease in the immediate allergy incidence, an increase in the delayed allergy incidence), cross reactions, the significance of the hidden allergen sources. Apart from that, the paper discusses the most important issues concerning the evolution of allergy to other antibiotics, especially the aminoglycoside antibiotics and cephalosporins.

Anti-Bacterial Agents↗
PubMedDate not supplied

Contact sensitivity to hair dyes can be detected by the consumer open test.

To avoid allergic reactions to hair dyes, an open test ("skin sensitivity test" or "dab test") is recommended 48 hours before the hair colouring procedure. We have investigated in a multicenter study, under standardized conditions and medical supervision, the validity of this test as a practical method to detect allergy to paraphenylenediamine (PPD)-containing hair dyes in 30 PPD patch test-positive and 30 PPD patch test-negative subjects. A defined volume of a marketed hair colouring product containing 1.8% PPD was applied in an open patch test to the retroauricular area. The grading method comprised the dermatologist's clinical evaluation and objective numerical scores. Allergic reactions were elicited in all PPD-positive subjects with a maximal intensity on Day 2; no allergic reactions were elicited in PPD-negative subjects. Increased severity of reactions by the dermatologist's clinical evaluation was correlated strongly with increasing numerical scores. The "skin sensitivity test" can be considered as an effective method to detect type IV hair dye allergy and as such, as an important factor in its secondary prevention.

Adolescent↗