Biomedical subjects

Egil Johnson

Publications and source records attributed to Egil Johnson.

21 records · Page 2Linked to original sources

PubMed2003

Resection rectopexy for internal rectal intussusception reduces constipation and incomplete evacuation of stool.

OBJECTIVE: To study the effect of rectopexy and sigmoid resection (resection rectopexy) on symptoms in patients with internal rectal intussusception. DESIGN: Retrospective and prospective study. SETTING: University hospital, Norway. PATIENTS: 22 patients with internal rectal intussusception. INTERVENTIONS: Resection rectopexy by an open (n = 13) or laparoscopically-assisted (n = 9) technique. MAIN OUTCOME MEASURES: Symptomatic outcome, patients' satisfaction, and morbidity. Outcome was based mainly on the validated KESS score, which covers 10 symptoms included in the definiton of constipation. RESULTS: There was a significant reduction in all 10 symptoms. Two patients complained of incontinence which improved after operation. The number of patients with constipation was reduced from 20 to 8 (p = 0.000) and none became constipated. Mean (95% CI) colonic transit times before and after operation in 10 patients with constipation were 5.3 (4.1 to 6.4) and 4.0 (2.6 to 5.4) days (p = 0.083). Seven of these 10 patients had a reduction of both transit time and constipation score. Six patients had complications after open operations. These included one damaged ureter, reoperations for bleeding, incomplete intestinal obstruction, and 2 wound infections. CONCLUSION: Rectopexy with sigmoid resection resulted in improvement in symptoms, including constipation and feeling of incomplete rectal evacuation, and acceptable morbidity.

Adult↗

PubMed2002

[Laparoscopic surgery in Norway].

BACKGROUND: Laparoscopic procedures in gastrointestinal surgery have increasingly been used over the last ten years. This study explores the use of various common laparoscopic procedures in Norway. METHODS: A questionnaire was sent to all 59 public hospitals in Norway in January 1999, of which all but one responded. Laparoscopic surgery was performed in 54 out of 58 hospitals. RESULTS: Most hospitals perform between 11 and 20% of all gastrointestinal operations with laparoscopic technique. Laparoscopic cholecystectomies and anti-reflux surgery have generally replaced open procedures in all hospitals. Appendectomy by the laparoscopic technique accounts for approximately 10% of cases and has become the preferred technique in only one of ten hospitals. Laparoscopic hernia repairs are done in less than 10% of cases. Overall, surgeons' satisfaction with laparoscopy is good and seems slightly higher in district and central hospitals than in university hospitals. Half of all surgical departments plan to use more laparoscopic procedures. INTERPRETATION: Laparoscopic procedures have replaced conventional open surgical procedures for some procedures but is less used than expected ten years ago. A slow and gradual increase may be expected in the years ahead.

Appendectomy↗

PubMed2002

Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro.

We have examined complement receptors on human umbilical vein endothelial cells (HUVEC) and found that they express complement receptor 1 (CR1, CD35) and complement receptor 4 (CR4, CD11c/CD18), but not complement receptor 3 (CR3, CD11b/CD18). Binding of monoclonal antibodies against CR1 (CD35) and CR4 (CD11c/CD18) to HUVEC was demonstrated by flow cytometry. The presence of the corresponding mRNAs was confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR) and sequencing of the amplified cDNA fragments. When HUVEC were treated with inflammatory mediators, chemotactic agents or the secretagogue phorbol-12-myristate-13-acetate (PMA), no change in reactivity to CR1 (CD35) or CR4 (CD11c/CD18) monoclonal antibodies was detected on the surface of the cells compared with untreated cells. The presence of CR1 (CD35) and CR4 (CD1c/CD18) on HUVEC indicates that endothelial cells (EC) have the potential to bind C3b and iC3b, respectively, which both mediate biological effects in the course of complement activation.

Antibodies, Monoclonal↗