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Eiji Kanehira

Publications and source records attributed to Eiji Kanehira.

9 recordsLinked to original sources
PubMed2004

Acinic cell carcinoma of the trachea: report of a case.

Acinic cell carcinoma (ACC) is a very rare primary tracheal carcinoma. We report a case of primary ACC of the trachea, which represents, to the best of our knowledge, only the fifth such case ever documented. Pharyngolaryngoesophagectomy was necessary for complete resection because the tumor invaded the trachea widely, up to the cricoid cartilage and involving the cervical esophagus. Although invasion of the upper aerodigestive tract by neoplasma is rare, to achieve complete resection and an acceptable prognosis, even a tumor with low malignancy requires wide resection.

Carcinoma, Acinar Cell↗
PubMed2003

The effects of an additive small amount of a low residual diet against total parenteral nutrition-induced gut mucosal barrier.

BACKGROUND: Total parenteral nutrition (TPN) negatively influences the gut mucosal barrier. It has been suggested that enteral nutrition is effective against the harmful influence. METHODS: Forty-eight male Donryu rats underwent placement of a central venous catheter and tube gastrostomy. They were divided into six groups, receiving isocaloric nutrients in various proportions of PN and a low residual diet (LRD) for 7 days. RESULTS: Intestinal permeability, villous height and crypt depth, and number of secretory IgA-positive cells in the villus were measured. Intestinal permeability was significantly reduced in rats receiving an LRD corresponding to more than 15% of total caloric intake. Gut morphological structure was maintained in rats receiving an LRD corresponding to more than 10%. A higher number of IgA-positive cells was observed in rats receiving an LRD corresponding to more than 15%. CONCLUSIONS: A small amount of LRD could prevent decreases in gut mucosal integrity. There was a stepwise defense mechanism in the gut mucosal barrier.

Amine Oxidase (Copper-Containing)↗
PubMedDate not supplied

Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer.

Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU). TS has a polymorphic repeated sequence in the 5'-UTR and the polymorphism is associated with TS protein expression. TS polymorphism has been reported to link with the efficacy of 5-FU-based chemotherapy in colorectal cancer. In this study, we examined whether the association among TS polymorphism, TS mRNA expression and TS protein expression is also observed in gastric cancer tissues and whether the TS polymorphism is a prognostic factor for patients with gastric cancer. We quantified TS mRNA isolated from 115 gastric cancer tissues by real-time reverse transcription PCR and TS protein in 72 available samples by the fluoro-dUMP binding assay. These values were compared with TS genotypes of the samples determined by a PCR assay. The tumor with the 3R/3R genotype had higher TS protein expression than that with the 2R/3R genotype, although there is no association between the TS genotype and mRNA expression. The result suggests that mRNA translation is responsible for the genotype-dependent difference of TS protein expression, as is consistent with our previous observation in colorectal cancer. This association encouraged us to further examine the link of the TS genotype with the stage of disease and the prognosis of the patients. The clinicopathological analysis showed that gastric cancers with the 3R/3R genotype are at a more advanced stage than those with the combined 2R/2R and 2R/3R genotype. We observed a longer survival in those patients with the combined 2R/2R and 2R/3R genotype, compared with the 3R/3R genotype, although it did not reach significance when the patients who had received the oral fluoropyrimidines therapy were analyzed. These results warrant further large-scale clinical study of the role of the TS genotyping for the prediction of efficacy using 5-FU-based chemotherapy and prognosis in gastric cancer.

Adult↗