Biomedical subjects

Eimir Perez-Arjona

Publications and source records attributed to Eimir Perez-Arjona.

6 recordsLinked to original sources

PubMed2004

Current concepts on the expression of neurotrophins in the greater omentum.

The omentum has been utilized in Neurosurgery since the late 1960s. Its overwhelming effects on fibroblast and peripheral nerve growths were soon noticed. However, there was no direct evidence of production of any of the growth factors by the omentum, although substances were shown to be present in the omentum. Three animals were used in the study. After removal of the omentum in one, the tissue was submitted to PCR for BDNF, NT3/4 and NT5. Water was the negative control utilized. There was marked expression of all neurotrophins in the omentum, indicating local production of all those substances. The omentum has, for the first time, demonstrated to produce and not only accumulate neurotrophins. Utilization of this concept may permit transplant or transposition of parts of the omentum into the central nervous system for the management of multiple diseases, including vascular dementia, strokes, Alzheimer's disease or Moya-Moya disease.

Animals↗

PubMed2004

Basilar artery to bilateral posterior cerebral artery 'Y stenting' for endovascular reconstruction of wide-necked basilar apex aneurysms: report of three cases.

Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA stents bilaterally in a 'Y' configuration to reconstruct the BA apex for effective coil embolization. Three patients (aged 70, 65 and 37 years) with wide-necked basilar artery aneurysms presented for endovascular treatment. All aneurysms had necks that involved the bilateral P1 segments. Each patient was deemed an appropriate candidate for endovascular reconstruction. Patients were pretreated with clopidogrel (75 mg) and aspirin (325 mg) each day for 3 days prior to the procedure. Following induction of general anesthesia, access to the right femoral artery was obtained by placement of a 6F sheath. Intravenous heparin was administered to achieve an activated coagulation time (ACT) of approximately 300 seconds. A 6F guide catheter was placed within the left vertebral artery (VA) in two patients, the right VA in a third. Utilizing over-the-wire (OTW) technique, a microcatheter was advanced into the left P2-P3 junction of the PCA. A 300-cm 0.014-inch microwire was passed through the microcatheter into the distal PCA and the microcatheter was removed. In each case, two neuroform stents were prepared (SMART Therapeutics Inc., San Leandro, CA) and advanced OTW into the PCA with the most acute angle relative to the BA. The initial stent placed was 20 mm in length and was deployed from the P1 segment into the BA. The microwire was pulled retrograde into the BA apex, then advanced though the stent struts and into the right PCA. A second stent, 15 mm in length, was advanced OTW through the struts of the previously placed stent. It was then deployed from the P1 into the BA where it overlapped the first stent, resulting in a stent-in-stent 'Y' configuration at the BA apex. A microcatheter was advanced OTW into the BA apex aneurysm and coil embolization proceeded in the usual fashion. Following the procedure, each patient was maintained in the neurosurgical intensive care unit (NICU). All remained neurologically intact. The two elderly patients were discharged to home the morning following the procedure. The third patient suffered an upper GI bleed and was treated an additional 3 days in hospital. Oral clopidogrel (75 mg by mouth) and aspirin (325 mg by mouth) were continued daily for 4 weeks. The 'Y' stent configuration for reconstruction of the BA apex is a safe effective technique in patients with wide-necked BA aneurysms.

Adult↗

PubMed2003

Stereolithography: neurosurgical and medical implications.

We present material to define and understand the concept of Stereolithography (STL) and its potential benefits to the field of neurosurgery and other medical specialties. A historical and scientific review of the literature on stereolithography, its evolution and uses in neurosurgery, forensic medicine, and other medical specialties are described. Considerations regarding different techniques used to obtain STL are discussed. The reproduction of cranial and vascular structures using this technique is evaluated. Data acquisition and model fabrication are the two basic steps required for stereolithography to create custom models for multiple applications in cranio-facial surgery, vascular studies, orthopedic surgery, urology and forensic medicine, among others. Stereolithography is a relatively new technique which continues to grow in many medical fields. Pre-operative education of patients, better understanding of patient anatomy, and the creation of custom-made prostheses are proven benefits of this technique.

Blood Vessels↗

PubMed2003

Brain retraction injury.

This paper reviews the literature of the brain retraction injury during the last century. The review focused on the instrument characteristic as well as the physiopathological and histopathological damage of the brain induced by brain retraction. It was found that lesions were induced by cerebral ischemia. We conclude that a better monitoring system needs to be developed to avoid brain injury.

Animals↗

PubMed2002

Late outcome following central nervous system injury in child abuse.

OBJECTIVE: The object of this study was to increase our understanding of the social, clinical, radiographic and psychological consequences of child abuse after the initial insult and to describe the role of neurosurgery and other specialties in this context. METHODS: A review of the literature on child abuse (using scientific journals, textbooks, and internet reports) was conducted, with special attention given to child abuse in infants. The biomechanical patterns of injury, the long-term neurological, psychological, and social outcomes and methods of rehabilitation are reviewed. CONCLUSIONS: Head injury associated with physical abuse carries a significantly worse clinical outcome than accidental trauma. Late findings in CT scans and MRI show evidence of cerebral atrophy in 100% and cerebral ischemia in 50% of physical abuse cases. Abuse and neglect have a strong impact in developing children, producing emotional, cognitive, and social problems that may persist throughout the rest of their lives. Outcome cannot be improved without an integrated rehabilitation strategy encompassing early field management, hospital therapy, precise targeting of educational and cognitive needs, and finally return to the community. New ancillary tests have emerged that are aimed at improving rehabilitation and illuminating the long-term physiological and functional impact of abuse.

Central Nervous System Diseases↗

PubMed2002

CNS child abuse: epidemiology and prevention.

The problem of child abuse and the central nervous system implications are reviewed from a multidimensional approach. Statistics regarding prevalence, risk factors, epidemiological considerations, and physiological aspects are studied. The incidence is reviewed in the United States and in other countries where incidence and social services are also described. Implications for prevention efforts are considered.

Age Factors↗