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Biomedical subjects

Eisuke Matsushima

Publications and source records attributed to Eisuke Matsushima.

At least 19 recordsLinked to original sources

Increased inhibition and decreased facilitation effect during a lexical decision task in children.

Widespread theories propose that implicit memory is established in the early stages of development, while explicit memory continues to develop until later stages. However, recent studies have argued that implicit memory changes developmentally. In order to elucidate the differences of implicit memory and semantic memory structures between children and adults, a single-word presentation method was developed using lexical decision tasks in which repeated real words, related real words, unrelated real words and pseudowords were presented in a list. Semantic priming and repetition priming using a single-word presentation method were employed in 25 children and 18 adults. Reaction time (RT) and correct rate for real words following pseudowords served as the base. Inhibition effect was defined as an increase in RT between a real word preceded by an unrelated real word and a real word preceded by a pseudoword. Facilitation effect was defined as a decrease in RT between a real word preceded by a related real word and a real word preceded by a pseudoword. Although the effect sizes of semantic priming did not differ between children and adults, the inhibition effect was larger and the facilitation effect was smaller in children. Repetition priming in children did not differ from that in adults. These findings challenge the idea of developmental invariance in implicit memory, suggesting that the strength of links between nodes in the semantic network increases and the range of spreading activation expands developmentally.

Adult↗

An evaluation strategy for the early detection of postoperative delirium.

The aim of the present study was to identify clinical signs detective of the postoperative delirium at the early stage for nursing management. A total of 66 inpatients undergoing cardiac surgery were interviewed using the Delirium Rating Scale (DRS) and NEECHAM Confusion Scale (NCS) preoperatively and on days 1 and 3 postoperatively. The mean onset of delirium occurred on postoperative day 1.3. Development of delirium was detected early by cognitive impairments in the DRS subscales of perceptual disturbance, hallucination, and cognitive status, and the NCS subscales of attention, command, orientation, and verbal skill. These results suggest that assessment of cognitive status on postoperative day is an important strategy in the early detection of postoperative delirium.

Confusion↗

[Eye movement in patients with schizophrenia].

To clarify the cognitive function of schizophrenia, the exploratory eye movement was investigated using S-shaped figures in patients with schizophrenia and their relatives. As a result, the exploratory eye movement has been found to be a biological marker that reflects a specific and trait factor of schizophrenia. Using the exploratory eye movement combined with brain functional imaging, the pathology of schizophrenia that the neural network centering on thalamus was damaged is being clarified. Moreover, the disease gene of schizophrenia may be discovered especially on the chromosome 22 using the exploratory eye movement as an endophenotype. In addition, the exploratory eye movement can be given as a powerful candidate of diagnostic tool for schizophrenia.

Adult↗

Spiritual needs in cancer patients and spiritual care based on logotherapy.

BACKGROUND: The suitability of Frankl's logotherapy for the spiritual care (psychotherapy) of cancer patients in Japan is suggested. Using Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp, Japanese version), the Purpose in Life test (PIL test, Japanese version), and WHO-Subjective Inventory (WHO-SUBI, Japanese version), we attempted to elucidate the complicated structure of spirituality in cancer patients in order to identify possible approaches to their spiritual care and means of evaluating such care. MATERIALS: Two hundred and ninety-eight cancer patients participated in the study. All three tests were taken at the same time, and the results were evaluated by principal component analysis. RESULTS: It was demonstrated that all the subscales employed in the present study could be represented by a two-dimensional structure (two principal components), and that the FACIT-Sp and PIL tests have similar contents. DISCUSSION: FACIT-Sp (Japanese version) is very similar in conception to the PIL test, which was prepared in accordance with logotherapy. The results suggest that this test can serve as an adequate evaluation scale for measuring the effectiveness of spiritual care based on Frankl's logotherapy.

Adult↗

Delirium in inpatients with respiratory diseases.

The features of delirium in patients being hospitalized due to respiratory diseases were investigated. From the inpatients in the respiratory medical ward of Tokyo Metropolitan Hiroo General Hospital over the course of 1 year, the patients who had delirium were diagnosed by a semistructured interview. The total number of subjects was 454, and patients with delirium were 43. Various clinical factors were compared between the delirium group and non-delirium group. In the delirium group, there were many elderly patients of 70 years or older. Moreover, there were many patients who had a chronic respiratory disease, patients in which the respiratory diseases were mutually complicated, and patients in whom other diseases combined with the respiratory disease in the delirium group. There were also many patients in the Intensive Care Unit (ICU), and patients with an endotracheal intubation or extubation. Based on the results of a multiple logistic regression analysis, for age, ICU accommodation, and endotracheal intubation, the value of the delirium group was more significant than that of the non-delirium group. In half of the patients from the delirium group, delirium developed within 1 week after hospitalization. In the patients who died in the hospital, however, delirium often developed days after they had been hospitalized. It was suggested that the later developed delirium had a relation to the prognosis.

Adolescent↗

Anxiety and depression of patients with digestive cancer.

This study sought to characterize the psychological status of digestive cancer patients, and to investigate the relationship between psychological characteristics and clinical factors. Subjects were 85 inpatients scheduled to undergo surgery for digestive cancer and 26 control patients. The Japanese versions of Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS) were administered for all subjects before surgery, before discharge, and 6 months after discharge. Changes in HADS and SDS scores across the three examination days for three groups of subjects (advanced-phase, early phase, and control groups) were compared. The mean scores of anxiety and depression were significantly higher in the advanced-phase group than in the other two groups. Examination day showed a significant effect on depression; depression increased from before surgery to before discharge, and did not return to the preoperative level at 6 months after discharge, but no significant effect on anxiety. As for the relationship between psychological trends and clinical factors, anxiety in the 'middle age' and 'chemotherapy' groups was more severe than in the 'elderly' and 'no chemotherapy' groups. Depression in the 'medical treatment equipment', 'chemotherapy', and 'long-term hospitalization' groups was more severe than in the 'no equipment', 'no chemotherapy', and 'standard-term hospitalization' groups. These results suggest that we should pay careful attention to cancer patients undergoing surgery, especially young patients who are constantly at risk of anxiety, and assess their depression taking into account their disease and treatment conditions, especially after the time when their discharge is determined.

Adult↗

Cognitive dysfunction in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is an autoimmune-mediated collagen disease that results in multiorgan failure. It is the collagen disease most frequently associated with neuropsychiatric symptoms, which have been hypothesized to stem from certain types of cognitive dysfunction. Subjects were 21 patients with SLE (one man, 20 women; aged 16-55 years; mean age, 35.1+/-10.7 years) who were undergoing treatment in the rheumatology unit of a general hospital, and 17 healthy control subjects matched to the patient group with respect to age and gender (two men, 15 women; mean age, 35.9+/-6.3 years). They were administered various tests of cognitive function including verbal reasoning, non-verbal reasoning, verbal memory, non-verbal memory, attention and mental flexibility, psychomotor speed and frontal lobe function. In addition, the SLE patients were tested for antiphospholipid antibodies. The SLE patients performed worse than the control group on immediate, delayed and interference of the Rey verbal test and paired associate tests of Wechsler Memory Scale, and their reaction time was slower in Trail A and Trail B tests. Moreover, these findings were more pronounced in the group with major neuropsychiatric symptoms. However, no relationship was apparent between these deficits in cognitive function and the presence or absence of antiphospholipid antibodies. The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients.

Adolescent↗

Abnormal regional cerebral blood flow in systemic lupus erythematosus patients with psychiatric symptoms.

OBJECTIVE: Single-photon emission computed tomography (SPECT) studies have demonstrated decreased regional cerebral blood flow (rCBF) in systemic lupus erythematosus (SLE) patients. However, no study has done voxel-based analysis using statistical parametric mapping (SPM) that can evaluate rCBF objectively, and the relationship between rCBF and psychiatric symptoms has not been well investigated. Using L,L-ethyl cysteinate dimer (99mTc ECD) SPECT and SPM, we aimed to clarify the association of rCBF changes with psychiatric symptoms in SLE patients whose magnetic resonance imaging (MRI) showed no morphological abnormalities. METHOD: Twenty SLE patients and 19 healthy volunteers underwent 99mTc ECD SPECT. Data were collected from August 2000 to March 2003. SLE was diagnosed according to American College of Rheumatology criteria, and psychiatric symptoms were diagnosed according to ICD-10 criteria. On the basis of the modified Carbotte, Denburg, and Denburg method, the patients were classified into 3 groups: a group with major psychiatric symptoms (hallucinosis, delusional disorder, and mood disorder), a group with minor psychiatric symptoms (anxiety disorder, dissociative disorder, and emotionally labile disorder), and a group without psychiatric symptoms. Gross organic lesions were ruled out by brain MRI. Group comparisons of rCBF were performed with analysis using SPM99. RESULTS: SLE patients without MRI lesions showed decreased rCBF in the posterior cingulate gyrus and thalamus. The reduction in rCBF was overt in patients with major psychiatric symptoms. CONCLUSION: Our study indicated that SLE patients may have dysfunction in the posterior cingulate gyrus and thalamus and that this may be associated with the severity of psychiatric symptoms.

Adolescent↗

[Quality of life and psychological traits of patients undergoing surgery for gastrointestinal cancer].

The purpose of this study was to assess the pre- and post-operative quality of life (QOL) of patients with gastrointestinal cancer and to investigate the relationship between QOL and various psychological and clinical factors. Eighty-five patients who underwent surgery for gastrointestinal cancer and 26 control patients undergoing surgery for digestive diseases other than cancer were interviewed. Two tests were administered to assess QOL and psychological status, respectively: the Japanese-language version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C 30 and the Japanese-language version of the Hospital Anxiety and Depression Scale (HADS). Each test was administered before surgery, before discharge and 6 months after discharge. Changes in EORTC QLQ-C 30 sub-scale scores over time were compared among advanced-phase, early-phase, and control patients. All groups showed significant changes in subscale scores of QOL. The scores of the advanced-phase group indicated worse QOL than the early-phase and control groups in many areas. The results suggest that QOL in gastrointestinal cancer patients is variable over time and is influenced by various clinical factors including the depression and anxiety.

Adaptation, Psychological↗

Human auditory evoked mismatch field amplitudes vary as a function of vowel duration in healthy first-language speakers.

Previous auditory studies demonstrated that vowel shortening elicited a more prominent mismatch component than its lengthening in event-related potentials (ERP) and magnetoencephalography (MEG). Based on these findings, the current study investigated whether the magnetic mismatch field (MMF) component would be generated by vowel shortening of various degrees to determine a neuronal response threshold of pre-attentive deviation detection. Behavioral pre-test data revealed that while listening to Japanese short-duration (100%: reference), long-duration (180%), and other in-between duration-synthesized types, healthy native speakers of Japanese failed to clearly categorize 140-124% durations as either short or long words, while categorizing 108-116% durations as short words and 148-172% durations as long. Following these results, MEG responses were recorded with a whole-head 148-channel magnetometer, as subjects listened to 100% standard and five deviant durations (124, 132, 140, 148, 180%). MEG results showed that the above-32% duration decrements (180-->100%, 148-->100%) elicited a more prominent MMF than the others, the MMF amplitudes increasing linearly to the degree of duration deviance, and that neuronal responses correlated with behavioral word-categorization accuracy.

Acoustic Stimulation↗

Functional MRI mapping of brain activation during visually guided saccades and antisaccades: cortical and subcortical networks.

Antisaccade tasks require a subject to inhibit a saccade toward a briefly appearing peripheral target and instead to immediately generate a saccade to an equivalent point in the opposite hemifield. Using functional magnetic resonance imaging (fMRI), we investigated the neural networks required to inhibit reflexive saccades and to voluntarily generate saccades. The results demonstrated that saccade and antisaccade tasks often bilaterally activate frontal, parietal and supplementary eye fields, lenticular nuclei and occipital cortex. Additional activation of bilateral dorsolateral prefrontal cortices, supramarginal gyri, anterior cingulate cortices and thalamus was observed during antisaccade tasks. These results indicate that fronto-parietal and fronto-striato-thalamo-cortical circuits are involved in antisaccade tasks. The fronto-parietal circuit is thought to be related to the planning of saccadic eye movements that involve attentional control, while the fronto-striato-thalamo-cortical circuits connect to cortical region as a feedback network. We speculate that the abnormalities in spatial attention and eye movement control observed in schizophrenia stem from dysfunctions in the fronto-parietal and fronto-striato-thalamo-cortical circuits.

Adult↗

Long-term change in size of cerebral infarction: predictive value of brain perfusion SPECT using statistical parametric mapping.

A focus of infarction is surrounded by hypoperfused areas. The present study was undertaken to examine the long-term changes in the size of infarcts, the relationship between the size of an infarct and the extent of the surrounding hypoperfused areas, and the background of such changes. The subjects of this study were 11 patients with ischemic lesions of the brain who had undergone brain SPECT ((99m)Tc-ethyl cysteinate dimer) within 1 week after initial MRI, and who underwent MRI again more than half a year later. Statistical parametric mapping (SPM) was conducted to detect significantly hypoperfused areas on the SPECT images. Relative size of significantly hypoperfused areas on SPM and infarcts on T(2)-weighted MR images were measured. The patients were divided into two groups based on the percentage of the infarct's size relative to the size of the surrounding hypoperfused areas (75-125 and 0-39%). Infarcts in the '75-125%' group showed little change in size, while in the '0-39%' group infarcts increased slowly until it reached the same rate as the former group. All patients with infarct in the '0-39%' group were noted to have severe stenosis of the internal carotid arteries bilaterally. Patients having severe stenosis of the internal carotid artery often had a slowly enlarging infarct. SPM seems to be useful in predicting the ultimate size of the infarct.

Adult↗

Magnetic brain activity elicited by visually presented symbols and Japanese characters.

A standard model of word reading postulates that the posterior inferior temporal cortex is involved in the processing of written words. This processing probably occurs within 200 ms after stimulus presentation. In order to characterize this process more precisely, we conducted a MEG study during a reading task in nine right-handed normal Japanese subjects. The subjects were required to respond to a word pertaining to the human body so that all stimuli would be subject to the same semantic processing. The trials for non-target conditions, such as kanji words, meaningful kana words, kana pseudowords and symbols were analysed to avoid possible P300 effect. The magnetic response peak of around 200 ms for symbols was smaller than any of the other three letter conditions. This result may suggest that M200 reflects the word-specific process such as visual word form recognition.

Adult↗

Assessment of peri-operative quality of life in patients undergoing surgery for gastrointestinal cancer.

The purpose of this study was to assess the pre- and postoperative quality of life (QOL) of patients with gastrointestinal cancer and to investigate the relationship between QOL and various psychological and clinical factors. Eighty-five patients who underwent surgery for gastrointestinal cancer and 26 control patients undergoing surgery for digestive diseases other than cancer were interviewed. Two tests were administered to assess QOL and psychological status respectively: the Japanese-language version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the Japanese-language version of the Hospital Anxiety and Depression Scale (HADS). Each test was administered before surgery, before discharge, and 6 months after discharge. Gastrointestinal tumors were localized to the stomach, colon, or rectum in 88% of cases and classified as advanced stage or early stage according to staging protocols. Changes in EORTC QLQ-C30 subscale scores over time were compared among advanced stage, early stage, and control patients. All groups showed significant changes in subscale scores of QOL; the scores of the advanced-stage group indicated worse QOL than the early-stage and control groups in a lot of areas. The physical function (PF2) QOL subscore was influenced by diagnosis, postoperative complications, medical equipment at discharge, and the length of admission and negatively correlated with depression and anxiety. These results suggest that QOL in gastrointestinal cancer patients is variable over time and is influenced by various clinical factors. Therefore, consideration of these clinical factors is paramount to the optimal care of gastrointestinal cancer patients.

Adult↗

Mutation screening and association study of the beta-adrenergic receptor kinase 2 gene in schizophrenia families.

Chromosome 22q12 is one of the most promising regions for harboring a risk gene for schizophrenia. We have reported significant linkage of intermediate phenotypes for schizophrenia with markers within or near the beta-adrenergic receptor kinase 2 (ADRBK2, or GRK3) gene, which is highly expressed in dopaminergic pathways in the central nervous system, and mediates homologous desensitization for a variety of neurotransmitters and hormones through phosphorylation of G protein-coupled receptors (GPCRs). A polymorphism in the promoter region of the ADRBK2 was reported to be associated with bipolar disorder. We screened the putative promoter region, and all 21 exonic and flanking intronic regions of the ADRBK2 gene for mutations in 48 schizophrenia probands (including 16 Japanese and 32 Chinese patients), and evaluated the detected polymorphisms and those reported in the JSNP database for associations with schizophrenia in 113 family trios of schizophrenia probands. Four single nucleotide variants in the 5'-UTR/promoter region, and 16 rare variants in exonic and flanking regions, were identified. Among them, the Cys208Ser variant was the only non-synonymous mutation. Cys208Ser was found in one family without cosegregation between the variant and schizophrenia. Moreover, allelic, genotypic and haplotypic analyses provided no evidence for association between alleles at these polymorphisms and schizophrenia. The present study indicates that the ADRBK2 gene is unlikely to contribute strongly to schizophrenia susceptibility in this set of families.

Alleles↗

Reliability and validity of the Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp) for Japanese patients with cancer.

The reliability and validity of the Japanese version of the Functional Assessment of Chronic Illness Therapy-Spiritual (FACIT-Sp) scale were assessed. This scale was developed in the United States to assess quality of life (QOL) in relation to spirituality. Two surveys were conducted on each of 306 cancer patients. In addition to the FACIT-Sp, the Hospital Anxiety and Depression Scale (HADS) was administered. Cronbach's alpha reliability coefficient, an evaluation of internal consistency, for the FACIT-Sp subscales ranged from 0.81 to 0.91. There were no significant differences between the patients evaluated using the FACIT-Sp subscale and the HADS subscale with regard to degree of religious feelings. The correlation coefficients between the FACIT-Sp and the HADS depression and anxiety scales indicated a moderate correlation. These findings suggest that the Japanese version of the FACIT-Sp scale is satisfactory in terms of reliability and validity and is a useful tool in the study of spirituality among Japanese cancer patients.

Adult↗

An fMRI study of differential neural response to affective pictures in schizophrenia.

Although emotional dysfunction is considered a fundamental symptom of schizophrenia, studies investigating the neural basis of emotional dysfunction in schizophrenia are few. Using functional magnetic resonance imaging (fMRI) and a task viewing affective pictures, we aimed to examine automatic emotional response and to elucidate the neural basis of impaired emotional processing in schizophrenia. Fifteen healthy volunteers and 15 schizophrenics were studied. During the scans, the subjects were instructed to indicate how each of the presented pictures made them feel. Whole brain activities in response to the affective pictures were measured by fMRI. Controls recruited the neural circuit including amygdaloid-hippocampal region, prefrontal cortex, thalamus, basal ganglia, cerebellum, midbrain, and visual cortex while viewing unpleasant pictures. Despite an equal behavioral result to controls, the patients showed less activation in the components of the circuit (right amygdala, bilateral hippocampal region, medial prefrontal cortex (MPFC), basal ganglia, thalamus, cerebellum, midbrain, and visual cortex). This study demonstrated functional abnormalities in the neural circuit of emotional processing in schizophrenia. In particular, decreased activation in the right amygdala and MPFC appears to be an important finding related to dysfunctional emotional behavior in schizophrenia.

Adult↗