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Biomedical subjects

Eliaz Kaufman

Publications and source records attributed to Eliaz Kaufman.

5 recordsLinked to original sources
PubMed2003

Beta-glucuronidase activity in saliva: relationship to clinical periodontal parameters.

BACKGROUND: Beta-glucuronidase (betaG) in gingival crevicular fluid (GCF), a marker of neutrophil influx into the crevicular environment, has previously been shown to be correlated with periodontal clinical parameters at individual sites (probing depth and clinical attachment level). Furthermore, elevated levels of betaG were found to be a risk factor for periodontal attachment loss. Analysis of betaG in saliva may be a measure of crevicular neutrophil influx for the whole mouth. The purpose of this cross-sectional study was to evaluate the relationship between betaG activity in saliva and periodontal clinical parameters in subjects demonstrating various levels of periodontal disease. METHODS: The study population consisted of 380 subjects (108 males and 272 females). A sample of unstimulated whole saliva and a venous blood sample were obtained from each subject, and a periodontal examination, which included measurement of probing depth (PD), attachment level (AL), and gingival index (GI) was performed. The unmodified saliva samples were frozen at -20 degrees C and analyzed for betaG activity. The blood samples were analyzed for number of white blood cells, neutrophils, monocytes, lymphocytes, and platelets. Statistical analysis was conducted to determine the association between salivary betaG activity and the whole-mouth clinical periodontal parameters, complete blood count, smoking status, and age. RESULTS: Highly significant correlations between salivary betaG activity and mean probing depth (MPD), mean gingival index (MGI), and the number of sites with probing depth > or = 5 mm were found. When subjects were divided into tertiles based on their MPD and MGI, elevated salivary betaG activity was detected in subjects in the 2 upper tertiles. Logistic regression modeling was used to determine which of the clinical or laboratory parameters were able to identify patients with at least 4 sites with PD > or = 5 mm. Salivary betaG activity > or = 100 produced an odds ratio (OR) of 3.77. In comparison, current and former smokers had an OR of 3.15 and 2.29, respectively. CONLCUSIONS: The results suggest that a significant association exists between periodontal clinical parameters and salivary betaG activity. Due to the non-invasive and simple nature of saliva collection, this association should be studied to determine its usefulness as a screening test for periodontitis, and a means of monitoring the response to treatment.

Adult↗
PubMed2002

The diagnostic applications of saliva--a review.

This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

Animals↗
PubMed2002

One-stage maxillary sinus elevation using a bone core containing a preosseointegrated implant from the mandibular symphysis.

This report presents a novel surgical approach of a one-stage maxillary sinus elevation using a bone core containing a preosseointegrated implant harvested from the mandibular symphysis. As a result, the elevation of the floor of the maxillary sinus and the placement of the implant were achieved at the same time, and the required healing time was significantly reduced. Three months after placement of the implant in the symphysis, a bone core containing the implant was retrieved using a trephine. The bone core was placed in the resorbed posterior maxillary ridge, thereby elevating the maxillary sinus floor. The bone core containing the implant was allowed to heal for 5 months, after which the implant was restored and followed up for 30 months. This technique represents a surgical modification intended to avoid the conventional two-step sinus elevation surgery in which the surgical procedure of graft placement is followed by surgical implant placement. This approach requires significantly reduced healing time and provides an increased bone quality around the implant, which is of clinical importance, particularly in the posterior maxilla.

Adult↗
PubMedDate not supplied

Localized vertical maxillary ridge augmentation using symphyseal bone cores: a technique and case report.

Vertical augmentation of the alveolar ridge is intended to restore resorbed alveolar ridges. This procedure is important for the placement of dental implants in a favorable position and also to enhance restoration esthetics. This article presents an approach for vertical ridge augmentation in the anterior maxilla utilizing symphyseal bone cores. A patient presented with 2 localized bony defects around the maxillary lateral incisors. Following extraction of these teeth, vertical bone defects of 7 mm on the right and 6 mm on the left were observed in relation to the cementoenamel junction of the adjacent teeth. Two bone cores were harvested from the mandibular symphysis using a trephine. These bone cores were tapped into 2 predrilled osteotomy sites with corresponding diameters until stabilization was achieved. The 2 sites were grafted with demineralized freeze-dried bone allograft and a titanium-reinforced expanded polytetrafluoroethylene membrane. After 5 months, the membranes were removed and vertical ridge augmentation of 5 mm on the right and 4 mm on the left was observed. The width of the ridge was increased as well. Two implants were placed in favorable positions, restored after 6 months, and followed successfully for 1 year after loading. This technique represents a viable approach for augmentation of deficient alveolar ridges prior to the placement of dental implants.

Adult↗