Biomedical subjects

Elif Torun

Publications and source records attributed to Elif Torun.

3 recordsLinked to original sources

PubMed2006

[Post-traumatic bronchial stenosis: a case report].

Bronchial rupture due to tracheobronchial trauma is a very rare condition. Early evaluation is necessary in order to avoid irreversible changes such as fibrosis and bronchial stenosis. Cases with post-traumatic hemo-pneumothorax, pneumomediastinum, subcutaneous emphysema and atelectasis require consideration of bronchial laceration with urgent bronchoscopy and early surgery, if needed. A 15 year-old patient with a history of blunt chest trauma two years ago presented with symptoms of pulmonary infection. Radiological and bronchoscopic evaluation revealed right upper lobe atelectasis secondary to fibrosis. Patient underwent right upper lobectomy.

Adolescent↗

PubMed2005

Transbronchial needle aspiration in the diagnosis of endobronchial malignant lesions: a 3-year experience.

STUDY OBJECTIVES: To establish the diagnostic yield of transbronchial needle aspiration (TBNA) and its contribution to conventional diagnostic techniques (CDT) such as forceps biopsy, bronchial washing, and bronchial brushing in the diagnosis of malignant endobronchial lesions. DESIGN: Retrospective clinical study. PATIENTS: One hundred fifteen lung cancer patients MEASUREMENT AND RESULTS: We reviewed files of 115 lung carcinoma cases diagnosed in our clinic from 2001 to 2003 with endobronchial lesions sampled by CDT and TBNA. The lesions were classified into three groups: exophitic mass lesion (EML), submucosal disease, and peribronchial disease. The diagnostic yield of TBNA and CDT was compared to that of the combination of CDT and TBNA with respect to the type and location of the lesion and the histopathologic subgroups. Of the 115 cases, histology findings were confirmed by TBNA in 91 cases (79%), CDT in 75 cases (65%), and TBNA plus CDT in 105 cases (91%). The difference of the diagnostic yield of CDT vs TBNA plus CDT was statistically significant (p < 0.001). In peribronchial disease, the sensitivity of TBNA plus CDT was significantly better than CDT (87% vs 52%, p < 0.001). In EML and submucosal disease, addition of TBNA to CDT improved sensitivity from 85 to 100% and from 84 to 97%, respectively (p > 0.05). Regarding localization, the addition of TBNA to CDT increased sensitivity in the trachea and main bronchi, and in right upper and middle lobe lesions (p < 0.05). By the addition of TBNA to CDT, small cell lung cancer and non-small cell lung cancer cases demonstrated improvements in sensitivity from 74 to 100% and 61 to 87%, respectively. This significant difference (p < 0.05) was attributed to the peribronchial disease group. CONCLUSION: In the case of peribronchial disease, the addition of TBNA to CDT improves the diagnostic yield of the bronchoscopic examination.

Biopsy, Fine-Needle↗

PubMed2004

Effects of prognostic factors and treatment on survival in advanced non-small cell lung cancer.

In this study, 304 stage III-B and IV non-small cell lung cancer (NSCLC) cases diagnosed and followed up in our hospital between January 2000 and December 2002 are retrospectively analysed. The effects of demographic, clinical, laboratory findings and different therapeutic modalities on survival were investigated. Of the cases, 31 (10.2%) were women, 273 (89.8%) were men and mean age was 60.59 +/- 10.73. Analysis by the Kaplan-Meier method revealed that median survival was 6.0 +/- 0.5 (95% CI: 5.1-6.9) months and 12 and 24-month survival rates were 25.27 +/- 2.99% and 11.48 +/- 2.77% respectively. By univariate analysis of 33 parameters, 12 of them were found to be effective on survival and this relationship was statistically significant (p< 0.05). These parameters indicating poor prognosis were age > 70, ECOG performance score > 1, dyspnea, peripheral lymphadenomegaly (LAM), mediastinal invasion, pleural effusion, distant metastasis, elevated serum LDH, CA 19.9, CA-125 values, not receiving curative radiotherapy (RT) (> 50 Gy) or chemotherapy (CT). A multivariate analysis by Cox regression method revealed that advanced age, mediastinal invasion and metastatic disease were not independent prognostic factors on survival whereas ECOG performance score > 1 (p= 0.000), absence of CT (p= 0.000) and curative RT (p= 0.018), dyspnea (p= 0.035), peripheral LAM (p= 0.022) and pleural effusion (p= 0.043) were independent prognostic factors on survival.

Aged↗