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Biomedical subjects

Elio Salvaggio

Publications and source records attributed to Elio Salvaggio.

6 recordsLinked to original sources
PubMed2003

Amoxicillin-induced nephritis and tubulitis in a child.

The occurrence of interstitial nephritis in patients receiving antimicrobial therapy has frequently been reported in adults while it has rarely been described in children. We report the case of a patient treated with amoxicillin who presented hallucinations and serosanguineous blisters during treatment and developed renal failure a few days after discontinuation of the drug. On renal biopsy an interstitial nephritis with tubulitis was identified.

Acute Disease↗
PubMed2002

Health-related quality of life and disability in young patients with spina bifida.

OBJECTIVES: To assess the health-related quality of life (QOL) and disability in young patients with spina bifida and to correlate them with the clinical examination findings. DESIGN: Prospective multidimensional study by means of (1) clinical assessment, (2) self-administered questionnaire for general health, and (3) standardized disability measurements. Relationships between disability measurement, patient-oriented examination, and conventional clinical assessment were evaluated. SETTING: Pediatric department at a university hospital in Italy. PATIENTS: Twelve consecutive young patients with spina bifida (mean age, 15.2 y; range, 14-18 y). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The Medical Outcomes Study 36-Item Short-Form Health Survey, the FIM trade mark instrument, and the Barthel Index. RESULTS: As expected, disability was inversely related (r=.72, P<.02) to the physical aspect of QOL. Unexpectedly, for the mental aspects of QOL, less disability was associated (r=-.70, P<.05) with higher psychologic distress and severe role disability because of emotional problems. The findings at clinical examination, especially proximal deficit of inferior limbs (r=-.70, P<.05), were usually related to higher disability and lower physical aspects of QOL. CONCLUSION: There was no linear inverse correlation between disability and QOL in patients with spina bifida. Patients with mild disability needed as much psychologic support as patients with severe whole disability.

Activities of Daily Living↗
PubMed2002

Plasma antidiuretic hormone levels in children with spina bifida.

PURPOSE: Urological management of spina bifida patients is controversial. The goals of therapy of neurogenic bladder are continence, prevention of infections and preservation of urinary tract. Desmopressin has been recently used in a spina bifida population that is dry during the day (daytime continence was achieved with clean intermittent catheterization and anticholinergics) but wet at night. The aim of this study was to assess plasma antidiuretic hormone (ADH) levels in these children. MATERIALS AND METHODS: The study included 24 patients, 11 males and 13 females (mean age 6.4 years) referred to the Spina Bifida Centre of the Catholic University of Rome, and 57 normal age-matched controls. Morning (07.30-08.00 h) plasma ADH levels were measured using a specific radioimmunoassay. RESULTS: Plasma ADH levels (normal range 5-11 microg/l) did not differ between spina bifida population and healthy controls. Serum ADH had a mean of 6.8 microg/l in affected children and a mean of 7.4 microg/l in the controls. CONCLUSION: We conclude that the use of desmopressin in children with spina bifida should be reserved only in patients with decreased secretion of ADH, or may be useful in patients with persistent nocturnal incontinence to reduce night wetting. Therefore, research with a larger population is needed.

Child↗
PubMedDate not supplied

Clinical patterns of neurogenic bladder.

The neurogenic bladder represents a vesical dysfunction secondary to a congenital or acquired neurologic lesion, spinal dysraphism being the most common cause in pediatric age. According to the lesion level and severity, neurogenic bladder can be hypertonic hyperreflexic, hypotonic hyporeflexic or of mixed type characterized by different clinical and urodynamic patterns and the potential cause of nephrourologic complications. These types of neurogenic bladder require diversified treatments as anticholinergic drugs, clean intermittent catheterization and antibiotic prophylaxis, separately or in various combinations. Close follow-up of children is necessary to control and prevent the onset of complications with changes in medical therapy or surgical treatment if required.

Child↗
PubMedDate not supplied

Neurogenic bladder dysfunction: urodynamic evaluation.

The main goal in the management of children with neurogenic bladder is to preserve renal function and assure a socially acceptable continence. Urodynamic testing based on cystomanometry evaluation of intravesical pressure and flow measurement, at present is considered the examination of first choice in the diagnosis of neurogenic micturition disorders to better classify the type of bladder based on the risk of upper urinary tract impairment and be able to plan a specific, personalized management.

Child↗