Elizabeth Barker | PubMed Health

PubMed2005

Developing military nursing research priorities.

Congress established the TriService Nursing Research Program (TSNRP) in 1992 to serve the nursing research needs of the military. The TSNRP advances the science of military nursing to support mission readiness and deployment, improves the health and quality of life of military personnel, and provides optimal nursing care in settings worldwide. In 1995, the TSNRP Advisory Council commissioned the Institute of Medicine to make recommendations on management, research funding areas, resource allocation, and objectives. In 1996, the committee issued its report, The Program for Research in Military Nursing: Progress and Future Direction. A principal recommendation was that the TSNRP hold regular research priority-setting conferences. In response, since 2000, the TSNRP has held three conferences. This article follows up the Institute of Medicine report and summarizes the results of those conferences. The article describes conference processes, constituents, and conclusions and outlines future TSNRP research directions.

Congresses as Topic↗

PubMed2002

Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis.

Basic fibroblast growth factor (bFGF) is a potent mitogenic factor for smooth muscle cells, myofibroblasts, and fibroblasts, proliferation of which is a hallmark of idiopathic pulmonary fibrosis (IPF) and lymphangioleiomyomatosis (LAM). Mast cells produce bFGF and have been associated with pulmonary fibrosis. We hypothesize that smooth muscle cell/myofibroblast-like cells will be spatially associated with bFGF-containing mast cells and that bFGF receptors will be expressed on the effector cells in IPF and LAM. We performed quantitative immunohistochemistry for bFGF, mast cell tryptase, smooth muscle actin for smooth muscle cell/myofibroblast-like cells, and fibroblast growth factor receptors (Flg, Bek) and measured collagen and elastic fiber in lung sections from IPF (n = 14), LAM (n = 9), and control lung (n = 10). IPF and LAM lung contained more smooth muscle cell/myofibroblast-like cells than did control lung. bFGF-containing mast cells were abundant both in IPF and LAM and were associated with collagen, elastic fibers, and smooth muscle cell/myofibroblast-like cells in IPF. Flg was expressed on epithelial cells, endothelial cells, smooth muscle cell/myofibroblast-like cells, and macrophages in IPF. In LAM, Flg was expressed on epithelial cells adjacent to smooth muscle cell/myofibroblast-like cell aggregates. Bek was expressed dominantly on smooth muscle cell/myofibroblast-like cells in LAM and on smooth muscle cell/myofibroblast-like cells as well as neutrophils in IPF. These data suggest that mast cell-derived bFGF might exert fibrogenic, proliferative effects on smooth muscle cell/myofibroblast-like cells through its receptors.

Adult↗