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Biomedical subjects

Elizabeth Kuipers

Publications and source records attributed to Elizabeth Kuipers.

35 records · Page 2Linked to original sources

Trauma and hallucinatory experience in psychosis.

Recent research indicates that there may be phenomenological, symptom, and diagnostic associations between trauma and hallucinations. However, the nature of the relationship is poorly understood from a psychological perspective. We report a theoretically informed phenomenological study. From descriptions of reported traumas and hallucinations, we assessed the rates of four types of hypothesized association between traumas and hallucinations (direct, indirect, stress, and none) in 75 participants with nonaffective psychosis. In a subgroup who had experienced trauma (N = 40), 12.5% had hallucinations with similar themes and content to their traumas, 45% had hallucinations in which the themes were the same but not the content, and 42.5% had no identifiable associations between their hallucinations and previously experienced trauma. Traumas rated as intrusive were significantly associated with hallucinations rated as intrusive, although intrusive hallucinations were not associated with traumas in general. The traumas most likely to be associated with hallucinations were sexual abuse and bullying.

Accidents↗

Psychological investigation of the structure of paranoia in a non-clinical population.

BACKGROUND: Previous studies of paranoia have assessed only limited numbers of paranoid thoughts, and have not considered the experience from a multidimensional perspective or examined the relationship between different suspicious thoughts. AIMS: To assess a wide range of paranoid thoughts multidimensionally and examine their distribution, to identify the associated coping strategies and to examine social-cognitive processes and paranoia. METHOD: Six questionnaire assessments were completed by 1202 individuals using the internet. RESULTS: Paranoid thoughts occurred regularly in approximately a third of the group. Increasing endorsement of paranoid thoughts was characterised by the recruitment of rarer and odder ideas. Higher levels of paranoia were associated with emotional and avoidant coping, less use of rational and detached coping, negative attitudes to emotional expression, submissive behaviours and lower social rank. CONCLUSIONS: Suspiciousness is common and there may be a hierarchical arrangement of such thoughts that builds on common emotional concerns.

Adaptation, Psychological↗

Patient-rated mental health needs and quality of life improvement.

BACKGROUND: Patient-rated unmet need is cross-sectionally associated with quality of life. Its longitudinal relationship has not been established. AIMS: To test the hypotheses that: (a) higher patient-rated unmet need is associated with lower individual quality of life assessments by a patient over time; and (b) reduction in patient-rated unmet need precedes improvement in quality of life. METHOD: One hundred and one individuals using adult mental health services were asked to complete 6-monthly questionnaires, comprising quality of life (Manchester Short Assessment of Quality of Life, MANSA) and unmet need (Camberwell Assessment of Need Short Appraisal Schedule, CANSAS) assessments. RESULTS: Seventy-three participants provided 240 separate pairs of consecutive assessments. Random effects regression models indicated an impact on current quality of life for both average level of unmet need (B= -0.23, 95% CI -0.29 to -0.17) and change in unmet need over the past month (B= -0.04, 95% CI -0.02). CONCLUSIONS: Changes in patient-rated unmet needs may cause changes in quality of life.

Adult↗

Visual hallucinations in psychiatric conditions: appraisals and their relationship to distress.

OBJECTIVES: Visual hallucinations (visions) associated with psychiatric conditions are poorly understood. This study tested the hypothesis that appraisals of visions would predict distress associated with visions. It also aimed to describe typical appraisals of visions. DESIGN: A cross-sectional interview study of people with visual hallucinations. METHOD: Participants (N = 20) who had experienced visions caused by their psychiatric condition (i.e. not by additional pathology such as epilepsy or substance abuse) completed a semi-structured interview and the Beck Depression Inventory (BDI). Possible associations between appraisals of visions (e.g. of controllability or outcome) and distress were examined. Novel categories of appraisal were generated in an attempt to reflect individuals' experiences as closely as possible. RESULTS: Appraisals of negative outcome, but not control, predicted distress. Thus, if individuals believed that the persistence of their visions would result in unpleasant consequences, they experienced more distress. Neither the form nor content of the visions predicted distress, nor was current mood predictive. Five categories of appraisal were generated, and independent raters could assign these reliably. Preliminary analyses showed that where individuals appraised a vision as indicating a special task, gifts or powers, they experienced less distress. CONCLUSIONS: Appraisals of visions predicted the distress associated with visions. 'Objective' characteristics of visions were poorer predictors of distress, and appraisals did not simply follow from the content of the vision. However, current mood may partially determine appraisals. The novel categories of distress require replication but may help to guide clinical practice. Therapeutic interventions aimed at altering appraisals may reduce distress.

Adaptation, Psychological↗

The prediction of hallucinatory predisposition in non-clinical individuals: examining the contribution of emotion and reasoning.

BACKGROUND: Emotion, especially anxiety, has been implicated in triggering hallucinations. Reasoning processes are also likely to influence the judgments that lead to hallucinatory experiences. We report an investigation of the prediction of hallucinatory predisposition by emotion and associated processes (anxiety, depression, stress, self-focused attention) and reasoning (need for closure, extreme responding). METHOD: Data were analysed from a questionnaire survey in a student population (N = 327). RESULTS: Higher levels of anxiety, self-focus, and extreme responding were associated with hallucinatory predisposition. Interactions between these three variables did not strengthen the predictive effect of each. Depression, stress, and need for closure were not found to be predictors of hallucinatory experience in the regression analysis. CONCLUSION: Emotional and reasoning processes may both need to be considered in the understanding of hallucinatory experience.

Adult↗

Developing a theoretical understanding of therapy techniques: an illustrative analogue study.

OBJECTIVES: In psychological interventions, clients are often asked to review unhelpful beliefs. Surprisingly, there is no theoretical understanding of how beliefs are reviewed in therapy. Moreover, by understanding a therapeutic technique, potential interactions with symptom processes can be considered. An analogue study assessing the feasibility of researching therapy techniques is described, in which links between symptoms, reasoning style, and an experimental version of the cognitive therapy technique of belief evaluation are examined. DESIGN: Individuals without psychiatric illness (N = 30) completed (i) dimensional measures of depression, anxiety, and delusions, (ii) a measure of confirmatory reasoning (Wason's 2-4-6 task) both before and after instruction in disconfirmatory reasoning, and (iii) a belief evaluation task. RESULTS: Compared with individuals with a confirmatory reasoning style, individuals with a disconfirmatory reasoning style in Wason's task were less hasty in their data gathering, considered a greater number of hypotheses during the task, had higher intellectual functioning, and had lower levels of depressive symptoms. Conversely, the individuals with the strongest confirmatory reasoning had higher levels of depression and preoccupation with delusional ideation. Successful adoption of disconfirmatory reasoning was associated with less hasty decision-making and lower levels of preoccupation and distress by delusional ideation. Individuals with a disconfirmatory reasoning style reported more evidence both for and against their beliefs in the belief evaluation task. CONCLUSION: The preliminary evidence, from this small non-clinical group, indicates that evaluating beliefs may partially involve the use of confirmatory and disconfirmatory reasoning processes. Disconfirmatory reasoning, associated with less hasty data gathering and consideration of alternatives, may lead to better belief evaluation. In the context of clinical research indicating that individuals with delusions are hasty in their data gathering and have difficulty considering alternatives, a potential implication of the findings is that individuals with delusions may find belief evaluation in therapy.

Adult↗

An RCT of early intervention in psychosis: Croydon Outreach and Assertive Support Team (COAST).

BACKGROUND: Despite considerable interest in early intervention in psychosis, the evidence base for its effectiveness is sparse. We aimed to evaluate a new service in South London, UK, Croydon Outreach and Assertive Support Team (COAST) using a randomised controlled trial (RCT) during its first year. METHOD: Referrals were taken from local adult community mental health teams of those with documented first service contact in the last 5 years and a diagnosis of any functional psychosis. Those who consented (N = 59) were randomised to COAST or treatment as usual (TAU). COAST offered a range of interventions, including optimum atypical medication, psychological interventions (individual cognitive behavioural therapy and family intervention if appropriate) and a range of vocational and welfare help according to need. Whole team training was used to be able to offer these kinds of interventions. RESULTS: Outcomes were evaluated at baseline, 6 months and 9 months on a range of standardised clinical and social measures. Overall both COAST and TAU clients improved over time, but there were no significant improvements for COAST clients; a lack of significant results in the time x treatment interaction. There was a trend for COAST carers' quality of life to increase. Bed days were also less in COAST, but not significantly so. CONCLUSIONS: The lack of clearly demonstrated improvements for COAST is consistent with the published literature so far. The fact that both groups improved in symptoms and functioning over the year suggests that while access to early intervention is helpful, community adult mental health teams should aim to offer high quality input at any stage of psychosis in order to meet client and carer needs.

Adult↗

Why do people with delusions fail to choose more realistic explanations for their experiences? An empirical investigation.

Delusions can be viewed as explanations of experiences,. By definition, the experiences are insufficient to merit the delusional explanations. So why have delusions been accepted rather than more realistic explanations? The authors report a study of alternative explanations in 100 individuals with delusions. Patients were assessed on the following criteria: symptom measures, the evidence for the delusions, the availability of alternative explanations, reasoning, and self-esteem. Three quarters of the patients did not report any alternative explanation for the experiences on which the delusions were based. These patients reported significantly more internal anomalous experiences and had a more hasty reasoning style than patients who did have alternative explanations available. Having doubt in a delusion, without an alternative explanation, was associated with lower self-esteem. Clinicians will need to develop plausible and compelling alternative accounts of experience in interventions rather than merely challenge patients' delusional beliefs.

Adult↗

Expressed emotion in the relatives of people with epileptic or nonepileptic seizures.

PURPOSE: This study investigated Expressed Emotion (EE) in relatives of people with epileptic or nonepileptic seizures (NES). METHODS: In a cross-sectional study, we used the Five-Minute Speech Sample to explore EE in the key relative of people with epilepsy (n = 36) and those with NESs (n = 21), as well as levels of anxiety and depression and use of coping strategies. RESULTS: A significantly greater proportion of relatives of NES than epilepsy patients were rated as high EE. Hostility was evident in more high-EE epilepsy than high-EE NES relatives, whereas emotional overinvolvement and positive relationship ratings tended to be more common in high-EE NES relatives. High- and low-EE epilepsy relatives used problem-focused as opposed to emotion-focused coping strategies significantly more than half the time. High EE and seizure frequency were not associated. Age at onset of the disorder was higher in epilepsy patients with high- than with low-EE relatives. CONCLUSIONS: Irrespective of etiology, carers for people with seizure disorders may find it hard to adjust to the difficulties these disorders create. Interventions that encourage problem-solving, reappraisals of "loss" and education regarding the causes of some of the patients' behavioral and mood problems seem likely to be beneficial.

Adaptation, Psychological↗

Can virtual reality be used to investigate persecutory ideation?

The use of virtual reality permits individuals' reactions to standard controlled environments to be studied. It may therefore provide a means for understanding the interpretations of experience relevant to clinical disorders. The use of this technology for understanding persecutory ideation has not been investigated. A pilot study was undertaken to examine whether individuals have persecutory thoughts about virtual reality characters under controlled conditions and if there are factors that predict the occurrence of such thoughts.Twenty-four nonclinical participants entered a neutral virtual environment that contained computer-generated people. The participants completed dimensional assessments of items related to psychiatric symptoms and their thoughts about the virtual characters. Positive views about the virtual characters were common. However, a number of participants had ideas of reference and ideas of persecution about the virtual characters. Individuals who had persecutory thoughts about the virtual characters had significantly higher levels of interpersonal sensitivity and anxiety. The study provides direct evidence that individuals attribute mental states to virtual reality characters. Important for the study of clinical phenomena, some individuals have thoughts of a persecutory nature about virtual characters. Additionally, the findings indicate that feelings of interpersonal vulnerability and anxiety may directly contribute to the development of persecutory ideation in response to essentially neutral contexts. Virtual reality may prove to be a valuable methodology for developing an understanding of persecutory ideation.

Adult↗

The prevalence of personality disorders, psychotic disorders and affective disorders amongst the patients seen by a community mental health team in London.

BACKGROUND: There is a lack of information regarding the prevalence and co-occurrence of personality disorders, psychotic disorders and affective disorders amongst patients seen by community mental health teams. This study aims to describe the population of patients served by a community mental health team in South London in terms of demographic and clinical characteristics. METHOD: Computerised hospital records and keyworkers' caseloads were used to identify 193 patients. The Standardised Assessment of Personality was used to assess personality disorders and the Operationalised Criteria Checklist was used to assess psychotic and affective disorders. RESULTS: Fifty-two per cent of patients met the criteria for one or more personality disorders, 67 % of patients had a psychotic illness and 23 % had a diagnosis of a depressive disorder. Community psychiatric nurses (CPNs) mainly saw patients with psychotic illnesses. The non-psychotic patients seen by CPNs had extremely high rates of personality disorder. Patients seen by psychiatrists and psychologists had significantly lower rates of personality disorder. CONCLUSIONS: The prevalence of personality disorder is high amongst patients seen by community mental health teams. Possible explanations for this are presented and implications for community care are discussed.

Adolescent↗

Occurrence of hallucinatory experiences in a community sample and ethnic variations.

BACKGROUND: Hallucinations typically are associated with severe psychiatric illness but also are reported by individuals with no psychiatric history. AIMS: To examine the prevalence of hallucinations in White and ethnic minority samples using data from the Fourth National Survey of Ethnic Minorities. METHOD: Interviews of 5196 ethnic minority and 2867 White respondents were carried out. The respondents were screened for mental health problems and the Psychosis Screening Questionnaire asked about hallucinations. Those who screened positive underwent a validation interview using the Present State Examination. RESULTS: Four per cent of the White sample endorsed a hallucination question. Hallucinations were 2.5-fold higher in the Caribbean sample and half as common in the South Asian sample. Of those who reported hallucinatory experiences, only 25% met the criteria for psychosis. CONCLUSIONS: The results provide an estimate of the annual prevalence of hallucinations in the general population. The variation across ethnic groups suggests cultural differences in these experiences. Hallucinations are not invariably associated with psychosis.

Adolescent↗

A comparison of auditory hallucinations in a psychiatric and non-psychiatric group.

OBJECTIVES: To compare auditory hallucinations in a psychiatric and non-psychiatric sample. DESIGN: Between-participants group design: a psychiatric group of 14 patients with schizophrenia, and a non-psychiatric group of 16 participants with tinnitus. METHOD: Participants were interviewed using the Mental Health Research Institute Unusual Perceptions Scale (MUPS). RESULTS: The type of hallucinations differed: participants with tinnitus predominantly heard music, whereas the patients with schizophrenia heard voices speaking. The groups also differed in their explanations of the hallucinations. However, there were similarities in contributory factors, emotional responses and coping strategies. CONCLUSIONS: The study highlights the multi-dimensional nature of the auditory hallucinatory experience, and opportunities for intervention.

Adaptation, Psychological↗

A cognitive model of persecutory delusions.

A multifactorial model of the formation and maintenance of persecutory delusions is presented. Persecutory delusions are conceptualized as threat beliefs. The beliefs are hypothesized to arise from a search for meaning for internal or external experiences that are unusual, anomalous, or emotionally significant for the individual. The persecutory explanations formed reflect an interaction between psychotic processes, pre-existing beliefs and personality (particularly emotion), and the environment. It is proposed that the delusions are maintained by processes that lead to the receipt of confirmatory evidence and processes that prevent the processing of disconfirmatory evidence. Novel features of the model include the (non-defended) direct roles given to emotion in delusion formation, the detailed consideration of both the content and form of delusions, and the hypotheses concerning the associated emotional distress. The clinical and research implications of the model are outlined.

Cognition Disorders↗

Does meeting needs improve quality of life?

BACKGROUND: This study investigated the relationship between patient-rated unmet needs and subjective quality of life using routine outcome data. METHODS: 265 mental health service patients from South Verona were assessed using the Camberwell Assessment of Need, the Lancashire Quality of Life Profile, and other standardised assessments of symptoms, disability, function and service satisfaction. At 1-year follow-up, 166 patients were still in contact, of whom 121 patients (73%) were re-assessed. RESULTS: Higher baseline quality of life was associated with being male, a diagnosis of psychosis, higher disability, higher satisfaction with care, fewer staff-rated or patient-rated unmet needs, and fewer patient-rated met needs (accounting for 40% of the variance). Specifically, fewer baseline patient-rated unmet needs were cross-sectionally associated with a higher quality of life (B = -0.08, 95% CI -0.12 to -0.04). Apart from its baseline value, the only baseline predictor of follow-up QoL was patient-rated unmet need (B = -0.08, 95% CI -0.21 to -0.09), accounting for 58% of the variance in follow-up quality of life. Graphical chain modelling confirmed this association. CONCLUSIONS: The association between high numbers of unmet needs and low subjective quality of life appears increasingly robust across several studies. Future research will need to investigate whether changes in needs precede changes in quality of life. This study provides further evidence that a policy of actively assessing and addressing patient-rated unmet needs may lead to improved quality of life.

Disability Evaluation↗

Cognitive behaviour therapy for psychosis.

AIMS: It used to be thought that the problems of psychosis were qualitatively difference from those of other disorders and therefore unamenable to psychological interventions. However more recent evidence will be summarised which suggests otherwise. METHODS: A cognitive model of the positive symptoms of psychosis (Garety et al., 2001; Kuipers et al., 2006) is described which builds on work on the dimensions of symptoms of psychosis, the continuum between non-clinical and clinical populations, and the contribution of emotional processes, cognitive reasoning biases and social factors. RESULTS: Evidence from both epidemiological and empirical studies from our research group and others, support some of the pathways of symptom formation and maintenance proposed by the model. Specifically there is evidence for the role of trauma, social adversity and stress. These may trigger emotional responses and unusual experiences and together with reasoning biases lead to appraisals that can be defined as positive symptoms such as delusions and hallucinations. Similar processes interact to maintain symptoms. CONCLUSIONS: Cognitive models of psychosis have led to the development of cognitive behavioural treatments for delusions and hallucinations, which show some evidence of efficacy. Such treatments need to be refined in the light of recent research.

Cognitive Behavioral Therapy↗