Practical synthesis and guest-guest communication in multi-hemicarceplexes.
Single molecule hosts carrying three separately encapsulated guests are prepared in a seven step sequence in high overall yields.
Journal Article↗
Biomedical subjects
Elizabeth S Barrett
Publications and source records attributed to Elizabeth S Barrett.
Superbowl container molecules.
The design, chemical synthesis, guest binding, and self-assembly of tureen-shaped container molecules is presented. With a large noncollapsible interior and five external binding sites, each superbowl container host is shown to bind up to nine guest molecules in well-defined locations.
Calixarenes↗
Cavitand boronic acids mediate highly selective fructose transport.
The synthesis sugar-transport properties of a family of five cavitand rim-appended boronic acids are reported. These conformationally rigid compounds are not observed to leach out of lipophilic membranes, and they exhibit unprecedented fructose to glucose transport selectivities and give higher fluxes than other neutral boronic acids. These properties make the cavitand boronic acids the best artificial fructose transporters described thus far. [structure: see text]
Boronic Acids↗
Chiral biscavitand propellers: synthesis, conformations and multiple guest binding.
[structure: see text]. The synthesis and properties of molecules containing two cavitand bowls, with interbowl linkages comprising one carbon atom at various oxidation levels, are reported. A carbonyl-bridged biscavitand binds three CH2Cl2 molecules in the solid state through a helical conformation. Evidence for the same chiral conformation in the solution phase is presented.
Journal Article↗