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Biomedical subjects

Emilio L Ghisalberti

Publications and source records attributed to Emilio L Ghisalberti.

14 recordsLinked to original sources
PubMed2006

Quantitative co-occurrence of sesquiterpenes; a tool for elucidating their biosynthesis in Indian sandalwood, Santalum album.

A chemotaxonomic approach was used to investigate biosynthetic relationships between heartwood sesquiterpenes in Indian sandalwood, Santalum album L. Strong, linear relationships exist between four structural classes of sesquiterpenes; alpha- and beta-santalenes and bergamotene; gamma- and beta-curcumene; beta-bisabolene and alpha-bisabolol and four unidentified sesquiterpenes. All samples within the heartwood yielded the same co-occurrence patterns, however wood from young trees tended to be more variable. It is proposed that the biosynthesis of each structural class of sesquiterpene in sandalwood oil is linked through common carbocation intermediates. Lack of co-occurrence between each structural class suggests that four separate cyclase enzymes may be operative. The biosynthesis of sandalwood oil sesquiterpenes is discussed with respect to these co-occurrence patterns. Extractable oil yield was correlated to heartwood content of each wood core and the oil composition did not vary significantly throughout the tree.

Alcohols↗
PubMed2006

Cytotoxic resveratrol oligomers from the tree bark of Dipterocarpus hasseltii.

A new resveratrol tetramer, named diptoindonesin E, was isolated from the acetone extract of the tree bark of Dipterocarpus hasseltii, together with five known resveratrol oligomers (-)-epsilon-viniferin, laevifonol, (-)-alpha-viniferin, vaticanol B, (-)-hopeaphenol, and a coumarin, scopoletin. The structures of these compounds were determined from spectroscopic evidence. Cytotoxicity test of the isolated compounds showed that hopeaphenol strongly inhibited murine leukemia P-388 cells.

Animals↗
PubMed2006

An antifungal and plant growth promoting metabolite from a sterile dark ectotrophic fungus.

A sterile dark ectotrophic fungus isolated from roots of an Australian native grass, Neurachne alopecuroidea produces compound 1 in liquid cultures. The structure of the metabolite was determined by spectroscopic and X-ray diffraction studies. The metabolite shows activity against phytopathogens and plant growth promoting activity, properties that are also expressed in vivo by the ectotrophic fungus.

Antifungal Agents↗
PubMed2004

A compound from smoke that promotes seed germination.

Exposure of seeds to aerosol smoke or crude smoke extracts stimulates the germination of a number of fire-dependent and fire-independent plant species. We now report the identity of a germination-promoting compound present in plant- and cellulose-derived smoke. The structure of this compound, deduced from spectroscopic analysis and confirmed by synthesis, was shown to be that of the butenolide 3-methyl-2H-furo[2,3-c]pyran-2-one (1). Here we show that 1 promotes germination of a number of plant species at a level similar to that observed with plant-derived smoke water.

Asteraceae↗
PubMed2004

Two new cytotoxic isoprenylated flavones, artoindonesianins U and V, from the heartwood of Artocarpus champeden.

Two new isoprenylated flavones, artoindonesianins U (1) and V (2), have been isolated from the heartwood of Artocarpus champeden together with three known isoprenylated flavonoids, 5'-hydroxycudraflavone A, cyclocommunin and artonin B. The structures of the new flavones were elucidated on the basis of spectroscopic evidence. Both compounds 1 and 2 showed strong cytotoxic activity against P-388 cell lines.

Antineoplastic Agents, Phytogenic↗
PubMed2004

The Goodeniaceae.

The Goodeniaceae family contributes some of the more spectacular wildflowers found on the Australian continent. The bright and vibrant colours that characterise members of the family has attracted much horticultural interest. A number of species have traditionally been used for medicinal purposes by indigenous communities, and the phytochemistry of some has been investigated. These aspects are considered in this review to determine correspondence between the reputed medicinal effects and the bioactivity of the secondary metabolites produced.

Asteraceae↗
PubMed2004

Butenolides from a cultured microfungus, Acremonium sp.

Two related butenolides have been isolated from a culture broth of a strain of the fungus, Acremonium sp. Although the lactone acid (3) is a known compound, the structure of the lactone diacid (4), deduced by spectroscopic analysis, is assigned for the first time. This compound appears to be identical to a partly characterised metabolite isolated, along with 3, from Chaetomium indicum in 1953.

4-Butyrolactone↗
PubMed2002

Artoindonesianins N and O, new prenylated stilbene and prenylated arylbenzofuran derivatives from Artocarpus gomezianus.

A new prenylated stilbene, named artoindonesianin N (1) and a new prenylated arylbenzofuran, named artoindonesianin O (2), were isolated from Artocarpus gomezianus Wall. ex Trec. (Moraceae). Their structures were elucidated as 1 and 2 on the basis of spectroscopic evidence. Along with these new compounds, a known phenolic compound was also isolated from this plant and identified as oxyresveratrol (3).

Artocarpus↗
PubMed2002

New chlorinated diphenyl ethers from an Aspergillus species.

Two new chlorinated diphenyl ethers (5, 6) have been isolated from the culture broth of an Aspergillus species obtained from leaf litter, together with the known benzophenone sulochrin (1), the grisandiene geodin (2), and the diphenyl ether asterric acid (3). The structure of another metabolite, methyl asterrate (4), was confirmed by single-crystal X-ray structure analysis.

Antifungal Agents↗
PubMedDate not supplied

Cytotoxic properties of oligostilbenoids from the tree barks of Hopea dryobalanoides.

A new modified stilbene dimer, diptoindonesin D (1), was isolated from the acetone extract of the tree bark of Hopea dryobalanoides, together with seven known compounds, parviflorol (2), (-)-balanocarpol (3), heimiol A (4), hopeafuran (5), (+)-alpha-viniferin (6), vaticanol B (7) and (-)-hopeaphenol (8). Cytotoxic properties of compounds 1-8 were evaluated against murine leukemia P-388 cells. Compound 8 was found to be the most active with IC50 of 5.7 microM.

Animals↗