Biomedical subjects

Erdoğan Inal

Publications and source records attributed to Erdoğan Inal.

8 recordsLinked to original sources

PubMed2006

Accessory nerve function in lateral selective neck dissection with undissected level IIb.

BACKGROUND: To investigate the accessory nerve function in lateral selective neck dissections (LSND) performed in laryngeal squamous cell carcinoma patients without dissection of level IIB. METHODS: Fifteen LSND were performed in 11 N0 laryngeal carcinoma patients with preservation of level IIB. Distal latencies, compound muscle action potentials (CMAP), and electromyography findings were investigated before surgery, during the 3rd postoperative week, and 3 months thereafter to compare the effects of the procedure on the accessory nerve. RESULTS: Distal latencies and CMAP values were significantly lower in the early and late postoperative periods when compared with preoperative values. In 8 patients, there was no motor unit potential (MUP) in the early postoperative period. However, in the late postoperative period, there was no MUP loss. CONCLUSIONS: Only temporary functional deterioration of the accessory nerve was seen in patients in whom LSND was performed with undissected level IIB.

Accessory Nerve↗

PubMed2005

Sternocleidomastoid muscle flap reconstruction during parotidectomy to prevent Frey's syndrome and facial contour deformity.

We studied the incidence of Frey's syndrome and facial contour deformity in two groups of patients who had undergone superficial parotidectomy. One group was made up of 12 patients who were randomized to undergo reconstruction of the surgical defect with a sternocleidomastoid muscle flap; the other 12 patients did not receive a flap. All 24 patients were evaluated via a short questionnaire, the starch-iodine test, and a visual examination. On the questionnaire, none of the 24 patients said they experienced abnormal facial sweating, flushing, or warmth while eating, although 6 of the 12 patients in the nonflap group had a mildly positive starch-iodine test. No patient in the flap group had a positive test. The difference between the two groups was statistically significant (p < 0.05). No statistically significant difference was seen between the two groups with respect to cosmetic results.

Adult↗

PubMed2004

The significance of ferritin, lipid-associated sialic acid, CEA, squamous cell carcinoma (SCC) antigen, and CYFRA 21-1 levels in SCC of the head and neck.

OBJECTIVES: We investigated the value of some tumor markers in the diagnosis and treatment follow-up of squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: Ferritin, lipid-associated sialic acid (LSA), carcinoembryonic antigen (CEA), squamous cell carcinoma (SCC) antigen and CYFRA 21-1 levels were determined in 28 patients with squamous cell carcinoma and in a control group of 20 patients with benign lesions of the head and neck. The measurements were made before treatment and in the first and third months of treatment. RESULTS: The sensitivity rates were as follows: 10.7% for ferritin, 89.3% for LSA, 21.4% for CEA, 42.9% for SCC antigen, and 14.3% for CYFRA 21-1. The specificity was 100% for all the markers. The sensitivity increased to 96.4% when CEA and LSA were used in combination. Declines in the levels after treatment were significant for ferritin, CEA, SCC antigen, and LSA. No significant relationship was found between the marker levels and lymph node metastasis, stage, and histologic differentiation of the tumors. Only ferritin and LSA levels were correlated with tumor size. Squamous cell carcinoma antigen was the only marker that manifested high levels in patients who developed locoregional recurrence and/or mortality. CONCLUSION: Of the markers studied, LSA, CEA and SCC antigen may be of value in the evaluation of squamous cell carcinoma of the head and neck. Sensitivity and specificity rates may increase when they are used in combination.

Adult↗

PubMed2004

Thyroid gland invasion in advanced laryngeal and hypopharyngeal carcinoma.

OBJECTIVES: To assess the rate of thyroid gland invasion and the need for thyroidectomy in advanced laryngeal and hypopharyngeal carcinomas that require total laryngectomy. PATIENTS AND METHODS: Between 1994 and 2001, 129 total laryngectomy with ipsilateral hemithyroidectomy and 14 total laryngopharyngectomy with total thyroidectomy operations were performed for primary squamous cell carcinoma of the larynx and hypopharynx. In the surgical specimens of the patients, the presence of tumor invasion to the thyroid cartilage and thyroid gland was evaluated retrospectively by light microscopic examination. RESULTS: None of the laryngeal carcinoma patients had thyroid gland invasion whereas eight (57%) hypopharyngeal carcinoma patients had thyroid gland invasion. Twenty patients (16%) had evidence for thyroid cartilage invasion in the laryngeal carcinoma group. There were only three cases (21%) with thyroid cartilage invasion in the hypopharyngeal carcinoma patients. CONCLUSION: There may be no need for performing thyroidectomy in all total laryngectomy cases. We recommend thyroidectomy during total laryngectomy in laryngeal carcinoma cases with subglottic extension and advanced hypopharyngeal tumors. Except for these two conditions, the assessment of extralaryngeal extension and thyroid gland invasion will guide whether thyroidectomy should be performed or not.

Adult↗

PubMed2003

Comparison of pharyngoesophageal segment pressure in total laryngectomy patients with and without pharyngeal neurectomy.

BACKGROUND: To compare pharyngoesophageal segment (PES) pressure values in total laryngectomy patients with and without pharyngeal neurectomy (PN) in the early postoperative period. METHODS: Forty-five previously untreated laryngeal carcinoma patients were enrolled into this prospective randomized study. Twenty of them underwent total laryngectomy with PN, and 25 underwent total laryngectomy without PN. PES pressures were measured on the tenth postoperative day with a four-channel catheter. RESULTS: Average PES pressures in patients with and without pharyngeal neurectomy were 12.82 +/- 6.11 mmHg and 17.40 +/-.72 mmHg respectively (p <.05). When compared with the critical point of 20 mmHg that is closely related to voice attainment in the group without pharyngeal neurectomy, 10 (40%) patients had pressure levels greater than 20 mmHg and in the other group only 1 (5%) patient had a pressure level greater than 20 mmHg. The difference between the groups with pressure levels greater than 20 mmHg was found to be statistically significant (p <.05). CONCLUSIONS: Pharyngeal neurectomy results in a statistically significant decrease of PES pressures in total laryngectomy patients.

Adult↗

PubMed2003

[The beneficial effect of selenium against induction of squamous cell carcinoma of the tongue in rabbits].

OBJECTIVES: In a rabbit model of squamous cell carcinoma of the tongue, we monitored histopathologic changes and assessed the effect of selenium against carcinogenesis. STUDY DESIGN: The study included 36 male albino New Zealand rabbits. To induce squamous cell carcinoma of the tongue, 9,10-dimethyl-1,2-benzanthracene (DMBA)-acetone solution was applied three times a week for a duration of 20 weeks under anesthesia with xylazine hydrochloride and ketamine. The rabbits were randomly assigned to receive either pure tap water (24 rabbits) or tap water supplemented with 4 ppm sodium selenite (12 rabbits). One rabbit in each group was sacrificed at the end of 4, 8, 12 and 16 weeks, and the remaining rabbits at the end of 20 weeks for macroscopic and microscopic examination of the tongue. RESULTS: By week 20, two rabbits in the selenium group, and nine rabbits receiving tap water died from acute necrotizing bronchopneumonia due to pasteurellosis. Dysplasia was significantly less in selenium-receiving rabbits (16.7% vs 66.7%, p < 0.0001), and its development manifested a delayed onset. Carcinoma in situ was detected in 25% of tap water-receiving rabbits that remained alive by week 19 to 20, while none of the rabbits had carcinoma in situ in the selenium group. CONCLUSION: Our data demonstrate that selenium has an inhibitory and preventive effect against chemically-induced rabbit tongue carcinogenesis.

9,10-Dimethyl-1,2-benzanthracene↗

PubMed2003

[The effects of pharyngeal neurectomy and cricopharyngeal myotomy on postoperative deglutition in patients undergoing horizontal supraglottic laryngectomy].

OBJECTIVES: We compared the effects of pharyngeal neurectomy (PN) and cricopharyngeal myotomy (CPM) on postoperative deglutition in patients undergoing horizontal supraglottic laryngectomy (HSL). PATIENTS AND METHODS: The study included 20 male patients (mean age 53 years; range 39 to 67 years) who underwent HSL for squamous cell carcinoma of the larynx. Tumor stages were T1 in two, T2 in 16 , and T3 in two patients. None had received radiotherapy before surgery. In order to decrease cricopharyngeal muscle spasm following HSL, the patients were randomly chosen for CPM (n=11) and PN (n=9). The two groups were compared with respect to the time to postoperative oral food intake. RESULTS: No significant difference was found with respect to the time to postoperative oral feeding (mean 27 days, range 16 to 45 days in the CPM group; mean 25 days, range 16 to 36 days in the PN group; p>0.05). No significant relationship existed between primary tumor stages and the time to oral feeding (p>0.05). No complications were encountered in the two patient groups. CONCLUSION: In supraglottic partial laryngectomies, PN seems to be as effective as CPM to decrease postoperative cricopharyngeal muscle spasm, with additional advantages of ease and safety.

Adult↗

PubMed2002

Lymphatic metastasis to the supraretrospinal recess in laryngeal squamous cell carcinoma.

In order to evaluate lymphatic metastasis to the supraretrospinal recess (SRSR) in laryngeal squamous cell carcinoma (SCC), we separately dissected SRSR lymph nodes and submitted them to pathological examination. Fifty-three lateral neck dissections (LNDs), 2 radical neck dissections (RNDs), and 19 modified RNDs were performed in 49 previously untreated patients with laryngeal SCC. The nodal status of the patients was N0 in 29 patients, N1 in 17, and N2 in 3. The neck was pathologically positive in both RNDs (100%), in 7 of 19 modified RNDs (37%), and in 7 of 53 LNDs (13%). No SRSR lymph nodes were positive in any of the dissection materials. No metastasis was found in the SRSR lymph nodes in the N0 necks treated with LND, and none was found even in N1 and N2 necks treated with RND or modified RND. We conclude that the SRSR may be left undissected during treatment of an N0 neck with LND so that accessory nerve dysfunction can be minimized and operative time can be saved.

Adult↗